Globe artichoke is a native crop of the Mediterranean region with about 80% worldwide production. It is estimated that about 3,000 ha are grown in the U.S., mostly in California. Artichoke crop can be grown as a perennial, by vegetative cuttings, or as annual by seeds. Crop production can be limited by freezing winter temperatures leading to irreversible plant damage or by high summer temperatures causing poor head quality. Successful artichokes production, particularly in areas with constraining climatic conditions, requires proper selection of cultivars and planting dates. Cultivars with low vernalization requirements are more prone to a short growing season. The application of GA3 to overcome the lack of low temperatures and fulfill the vernalization requirements of early cultivars is well known. The goal of this multi-year project is to select production strategies contributing to earliness, extension of harvesting period, and improved yield and head quality under a variety of environmental conditions in Croatia and Texas. Selecting cultivars with different maturity groups and planting dates enabled harvesting period from autumn to late spring depending on locations. When GA3 was applied (12.5 to 125 ppm) on a naturally vernalized crop from autumn planting, early yield was substantially increased without affecting earliness. Conversely, application of GA3 (30 or 45 ppm) on nonvernalized plants established during late spring or summer was necessary for fall harvest in the Croatian locations. Head quality evaluated as head weight and size, or crude protein and total fiber concentration, progressively decreased during late spring harvest in Texas. Shifting the harvesting period towards early spring may be essential for improving head quality and for increasing the market share. To achieve adequate yields, longer harvesting period, and superior head quality, it is necessary to develop and adjust cultural practices for the specific growing area.