Ejina, a representative inland river basin situated in the arid region of northwest China, exhibits a delicate ecological environment and its vegetation coverage is intrinsically linked to regional ecological security. Based on MOD13Q1-NDVI data from 2018 to 2023 and groundwater depth monitoring data during the same period, this study analyzed the spatial–temporal variation characteristics of vegetation coverage and its relationship with groundwater depth in Ejina. It is found that the vegetation coverage in Ejina is generally low and mainly distributed along the riverbanks in the form of strips. During the study period, the overall trend of vegetation coverage showed a fluctuating pattern of first increasing and then decreasing, revealing the fragility of the regional ecology. The groundwater depth shows the characteristic of being higher in the east river than the west, and the trend of groundwater depth along the river flow is first increasing and then decreasing. The spatial groundwater depth indicates that the east river is higher than that of the west river, and the groundwater depth along the river flow first increases and then decreases. In terms of inter-annual changes, the groundwater depth experiences a process of first decreasing and then stabilizing. Further analysis indicates that vegetation growth and coverage in Ejina are significantly affected by water conditions, and areas with high Normalized Difference Vegetation Index (NDVI) values are mainly distributed along the riverbanks. In addition, there is a certain degree of correlation between groundwater depth and NDVI. When the depth of groundwater is too deep or too shallow, the positive correlation between NDVI and groundwater depth increases slightly and the negative correlation decreases slightly. The findings of this study are of great significance for understanding and predicting the response of vegetation coverage to groundwater changes in arid areas, and provide a scientific basis for water resources management and ecological protection in Ejina.
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