Gross primary productivity (GPP) is a key parameter in research on the global carbon cycle and changes. Understanding the spatiotemporal dynamics and influencing factors of GPP on the Loess Plateau (LP) helps identify the health status of ecosystems, thereby enabling the implementation of effective conservation and restoration measures. In this study, we used a modified vegetation photosynthesis model (VPM) to simulate a long-term series of GPP in the LP from 2001 to 2022, and the impacts of different land-use patterns and meteorological factors on GPP were investigated using a transition matrix, linear regression, and partial correlation analyses. The findings suggested that the modified simulation yielded a more reliable performance (coefficient of determination (R2) = 0.89, root mean square error (RMSE) = 143.47 gC·m−2·yr−1) and was suitable for further research endeavors. (1) The GPP on the LP significantly increased by 232.65 TgC from 2001 to 2022. The southeastern region contributed more than the northwestern region, and the GPP exhibited higher multi-year averages and growth rates below 1000 m elevation. (2) Forests in the southeastern region of the LP, characterized by a heightened growth rate, will influence future spatial variations in GPP increases across the LP. Despite the decline in grassland and cultivated land areas, substantial land coverage has significantly contributed to the overall GPP growth. Urbanization encroaching on cultivated land has emerged as a key contributor to the decline in GPP in low-altitude regions. (3) Air temperature was the main physical driving force for GPP change in the LP. Additionally, the GPP in forested regions exhibited a negative correlation with rainfall, whereas the GPP in areas undergoing the return of cropland to forest–grassland and cropland reclamation correlated negatively with solar radiation. (4) The attribution analysis indicated that the surge in vegetation GPP on the LP was collectively driven by human activities and meteorological changes, with human activities dominating these changes by 61.41 %. This study deepens the understanding of terrestrial ecology in semi-humid regions and provides scientific insights for implementing ecological governance strategies in the LP.