Background (Background, Rationale, Prior Research, and/or Theory): Health behaviors during the college years may develop into patterns that persist into adulthood. The National College Health Assessment survey estimates that less than 50% of college students meet the recommendations for physical activity each week and less than 6% meet recommendations for daily fruit and vegetable intake. An undergraduate personal health course (PHC) may improve health behaviors and is sometimes included as a graduation requirement. Objective: To assess the efficacy of a required PHC on various health-related endpoints and to describe challenges and opportunities for future courses. Study Design, Setting, Participants, Intervention: A retrospective review of four years of data from 1,049 women taking a required PHC at a small, women-centered, liberal arts university. Outcome Measures and Analysis: Trained professionals measured anthropometrics and health/activity-related parameters at the start (week 1) and end (week 15) of eight semesters. Pre and post data were compared using paired t-tests with SPSS version 24. Results: Significant differences were observed for all anthropometric measurements. From week 1 to week 15, body weight increased slightly (+0.3 kg; P = .023) while waist circumference decreased (-1.0 cm; P < .01). Flexibility, muscular strength, and cardiovascular capacity improved significantly. Nutrition assessments were inconsistent across semesters. Conclusions and Implications: This review is more robust than previously published work. Undergraduate PHCs can be efficacious in the short term. In this study, certain anthropometric measurements and markers of physical fitness improved over a 15-week semester. Meaningful dietary assessments prove challenging to conduct and interpretation of the findings is also difficult. Opportunities exist to better understand meaningful nutrition education components and nutritional assessments for PHCs in college populations. Future work should also consider methods to reliably assess the health impact of PHCs beyond graduation. Funding: St. Catherine University Summer Scholars Program.