Future human or robotic missions to the Moon will require efficient ascent path and accurate orbit injection maneuvers, because the dynamical conditions at injection affect the subsequent phases of spaceflight. This research is focused on the original combination of two techniques applied to lunar ascent modules, i.e. (i) the recently-introduced variable-time-domain neighboring optimal guidance (VTD-NOG), and (ii) a constrained proportional-derivative (CPD) attitude control algorithm. VTD-NOG belongs to the class of implicit guidance approaches, aimed at finding the corrective control actions capable of maintaining the spacecraft sufficiently close to the reference trajectory. CPD pursues the desired attitude using thrust vector control and side jet system, while constraining the rates of both the thrust deflection angle and the roll control torque. After determining the optimal two-dimensional ascent path, which represents the reference trajectory, VTD-NOG & CPD is applied in the presence of nonnominal flight conditions, namely those due to navigation and actuation errors, incorrect initial position, unpredictable oscillations of the propulsive thrust, and imperfect modeling of the spacecraft mass distribution and variation. These stochastic deviations are simulated in the context of extensive Monte Carlo campaigns, and yield three-dimensional perturbed trajectories. The numerical results obtained in this work unequivocally demonstrate that VTD-NOG & CPD represents an accurate and effective methodology for guidance and control of lunar ascent path and orbit injection.