Precision tests of the Standard Model (SM) require not only accurate experiments, but also precise and reliable theoretical predictions. Triple vector boson production provides a unique opportunity to investigate the quartic gauge couplings and check the validity of the gauge principle in the SM. Since the tree-level predictions alone are inadequate to meet this demand, the next-to-leading order (NLO) calculation becomes compulsory. In this paper, we calculate the NLO QCD + NLO electroweak (EW) corrections to the $W^{\pm}ZZ$ productions with subsequent leptonic decays at the $14~{\rm TeV}$ LHC by adopting an improved narrow width approximation which takes into account the off-shell contributions and spin correlations from the $W^{\pm}$- and $Z$-boson leptonic decays. The NLO QCD+EW corrected integrated cross sections for the $W^{\pm}ZZ$ productions and some kinematic distributions of final products are provided. The results show that both the NLO QCD and NLO EW corrections are significant. In the jet-veto event selection scheme with $p_{T,jet}^{cut} = 50~ {\rm GeV}$, the NLO QCD+EW relative corrections to the integrated cross section are $20.5\%$ and $31.1\%$, while the genuine NLO EW relative corrections are $-5.42\%$ and $-4.58\%$, for the $W^+ZZ$ and $W^-ZZ$ productions, respectively. We also investigate the theoretical dependence of the integrated cross section on the factorization/renormalization scale, and find that the scale uncertainty is underestimated at the LO due to the fact that the strong coupling $\alpha_s$ is not involved in the LO matrix elements.
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