The article presents data on the improved technique of vaginal hysterectomy (GE) with the use of medications and technical support in case of genital prolapse. The objective: was to determine the clinical effectiveness of preventive measures, the improved technique of vaginal GE in case of complete loss of the uterus with the use of drugs and technical support. Patients and methods. The main group included 21 women with total uterine prolapse, who underwent vaginal GE without uterine appendages according to the procedure we improved, and in the control group – 17 women, who underwent vaginal GE with a standard procedure. In the two groups after the vaginal GE, anterior and posterior colpoperineoraphy was performed with levatoroplasty. Results. We have improved the technique of conducting vaginal GE with the use of medications (hydroparreparation of the solution with 0.4 mg of terlipressin) and technical support (use of the radiofrequency scalpel and argon-plasma tissue coagulation), according to our study, significantly reduces the likelihood of intraoperative complications and improves postoperative period with respect to reparative Processes and a decrease in the frequency of hemorrhagic and pyoinflammatory diseases after surgery Skogen intervention. Conclusion. The clinical study determined the effectiveness of a comprehensive surgical technique for the complete loss of the uterus and prevention of possible complications of surgical intervention. Key words: vaginal hysterectomy, colpo-perineorrhaphy, levatoroplasty, synthetic analogue of vasopressin, argon-plasma coagulation of tissues.