According to global statistics, the frequency of local radiation reactions is on average 10% of the total number of patients who receive radiotherapy. The lack of effective measures to prevent their occurrence can lead to the transition of radiation reactions to radiation damage to healthy tissues that which will not only affect the quality of life of patients who have been cured of malignant tumours, sometimes leading to their disability, but also often cause fatal consequences. The authors of this work developed an ointment formulation based on emoxipin, a drug that has a targeted effect on blood vessels. The purpose of the study is to increase the effectiveness of the therapy for patients who are subject to local radiotherapy by using 1% emoxipine ointment. Material and methods. We conducted the observation of 29 patients with breast cancer, who were subject to adjuvant radiation therapy according to the standards of cancer diagnosis and treatments. Results and discussion. Preventive application of 1% emoxipin ointment one hour before the radiation session and in 1 and 2 hours following it prevented the occurrence of early local radiation reaction in 25% of patients compared to 63% of the participants who applied methyluracil ointment. Emoxipin ointment reduces reactive syndrome, vascular reaction and has an analgesic effect. Conclusion. This approach has been proven as effective means to prevent the transition of radiation reactions to radiation damage, it has significant economic efficiency as can exclude further therapeutic treatment of radiation lesions by using expensive drugs and thus, increases the effectiveness of conservative therapy.