Vascular Permeability In Rats Research Articles

Vascular leakage induced by horseradish peroxidase in the rat.

SummaryIntradermal, intraperitoneal and intravenous injections of horseradish peroxidase solutions induce increased vascular permeability in rats. The vascular leakage is confined to venules, is of short duration, can be inhibited by a combination of histamine and serotonin antagonists and is associated with mast cell degranulation. This phenomenon occurs also in the guinea pig but is minimal or non-existent in the mouse.

Evidence that hyaluronidase is not the factor in testicular extract causing increased vascular permeability.

The intravenous or local administration of relatively crude bull testis extract is capable of causing increased vascular permeability in rats. Purification of the hyaluronidase component of this extract results in loss of its capacity to induce increased vascular permeability. The purified hyaluronidase appears to retain its spreading activity.