BACKGROUND CONTEXT Minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) has been demonstrated to be effective in the surgical treatment of lumbar degenerative pathologies. Advances in instrumentation, such as the development of expandable interbody devices, have been made in order to improve surgical outcomes and patient satisfaction. Previous studies have investigated surgical outcomes of different interbody devices. However, few have analyzed differences in radiographic and patient reported outcomes (PROs) between expandable and static interbody devices. PURPOSE The purpose of this study is to evaluate differences in radiographic parameters and PROs following single-level MIS TLIF between static and expandable interbody devices. STUDY DESIGN/SETTING Retrospective analysis of a prospectively managed surgical database. PATIENT SAMPLE Sixty patients who underwent a primary, single level MIS TLIF between 2014 and 2017 that had completed at least six months of postoperative follow-up. OUTCOME MEASURES Improvements in lumbar lordosis (LL), segmental lordosis (SL), disc height (DH), and foraminal height (FH), and improvements in ODI, VAS back pain, and VAS leg pain. METHODS Patients who underwent primary, single-level MIS TLIF between 2014 and 2017 were retrospectively identified. Only patients that had completed at least six months of postoperative follow-up were included. Radiographic measurements including LL, SL, DH and FH were performed on lateral radiographs before and after MIS TLIF with a static or expandable articulating interbody device. Patient characteristics were compared using chi-squared analysis and independent t test for categorical and continuous variables, respectively. Radiographic outcomes and PROs were compared using paired and unpaired Student's t test. RESULTS Sixty patients undergoing MIS TLIF were included in this analysis. Thirty patients received expandable interbody devices and 30 patients received static interbody devices. There were no differences in demographics or perioperative characteristics between cohorts. Both static and expandable device cohorts demonstrated significant increases in DH, FH, and LL (p CONCLUSIONS Undergoing MIS TLIF with an expandable interbody device led to a greater increase of DH than with a static interbody device. Patients reported significant improvements in PROs following MIS TLIF in both expandable and static interbody device cohorts. However, no differences in improvement were demonstrated between surgical cohorts. Although use of expandable interbody device led to greater increases in DH, this may not correlate with superior patient outcomes. As such, patients undergoing MIS TLIF can expect similar improvements in PROs, whether receiving a static or expandable interbody device. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.