The study aimed to investigate the dynamic response of vehicles traveling on expressways across high and steep subgrade slopes under vehicle loads. This was done by creating a finite element model of high and steep subgrade slopes through ABAQUS software and its secondary program development. Specific engineering examples were used to analyze the dynamic response states and laws of high and steep subgrade slopes under varying vehicle speeds and load conditions. The study's results indicate that: (1) When the vehicle is travelling at 100 km/h, its vibration frequency is close to the natural frequency of the subgrade in the section, leading to strong dynamic responses. (2) As the number of axles increases, the pressure on the contact surface between the wheel and the roadbed rises, and dynamic responses become stronger. The four-axle vehicle shows the most significant dynamic response. (3) The maximum vertical stress fluctuates around an intermediate value over time. (4) The highest maximum vertical displacement value is observed in the penultimate analysis step, with a noticeable peak value. At this point, the vehicle load has the most prominent impact on the roadbed slope.