A lot of research on the prevalence of arthritis in India population has been carried out. However no studies on the genetic relationships within groups of arthritic patients in India have been reported. The current study focuses on analyzing the genetic diversity between patients suffering from the various types of arthritis with reference to factors inducing its onset. A total of 36 patients suffering from different types of arthritis were analyzed with reference to the age, gender, BMI, family history, hemoglobin and thyroid profile. The variation in the genetic profile was also analyzed using the RAPD technique. Data analysis showed patients suffering from arthritis to be at a greater risk of thyroid disorders, however the type of arthritis played a significant role. A distinct correlation between the genetic variation and presence of arthritis including its type was observed.