Human population growth has led to accumulation of large amount and variety of wastes, which take many decades to degrade and also release toxicity during degradation. A sustainable solution is required to treat these wastes to prevent our future population from environmental hazards. Recently, microbial fuel cell (MFC) technology has emerged as a potentially promising future technology for the production of energy from organic material present in wastewaters, thus ensuring dual benefits: waste treatment and energy production. In the present review the authors discuss the wider aura of wastewater treatment capabilities of MFCs and their future challenges to overcome to explore the opportunities for future MFCs.