The unprecedented rise in atmospheric aerosols, coupled with their intricate interactions with the environment through a wide array of physical, chemical, and biological processes, has profoundly impacted global climate. Their presence in the atmosphere scatters and absorbs solar radiation, thus altering the amount of sunlight reaching the Earth's surface. These direct effects, along with the indirect effects of aerosols, have significantly altered atmospheric temperatures, land surface processes, global surface temperature, hydrological cycle, and ecosystems. Understanding the complex interplay between aerosols and climatic variables necessitates a multidisciplinary approach, such as dependency modeling. Addressing these challenges, the current study conducts a spatiotemporal correlational analysis of selected key meteorological parameters with aerosol optical depth over East Africa (EA) using multisensory data from Moderate-resolution Imaging Spectroradiometer (MODIS), Modern-Era Retrospective analysis for Research and Application (MERRA-2) model, and Tropical Rainfall Measurement Mission (TRMM). Employing a weighted least squares regression (WLS) model, the study quantifies trends in the time series of climatic variables and Normalized Difference Vegetation Index (NDVI), further utilizing a statistical dependency modeling technique for correlational analysis. The trend analysis reveals a significant decreasing trend in surface wind speed (SWS) in most months, with sporadic positive trends attributed to anthropogenic activities, notably biomass burning, observed in January. Spatial trend analysis of Precipitation Rate (PR) displays heterogeneity, with significant negative trends in January and March, and positive trends in February, April, November, and December. Negative trends during May to August are attributed to increased anthropogenic activities, while enhanced positive trends in May correlate with low aerosol optical depth (AOD) during this period. Surface air temperature (SAT) exhibits diverse variations across the region, with dry months recording higher averages and trends than wet months. The study notes heterogeneous correlations in NDVI over the study area, with positive and negative correlations observed in different regions. Specifically, positive correlations are noted along the coastal and Lake Victoria regions, attributed to improved PR enhancing vegetation cover in these areas.