We perform a spectroscopic study to constrain the stellar Initial Mass Function (IMF) by using a large sample of 24,781 early-type galaxies from the SDSS-based SPIDER survey. Clear evidence is found of a trend between IMF and central velocity dispersion, sigma0, evolving from a standard Kroupa/Chabrier IMF at 100km/s towards a more bottom-heavy IMF with increasing sigma0, becoming steeper than the Salpeter function at sigma0>220km/s. We analyze a variety of spectral indices, corrected to solar scale by means of semi-empirical correlations, and fitted simultaneously with extended MILES (MIUSCAT) stellar population models. Our analysis suggests that sigma0, rather than [alpha/Fe], drives the IMF variation. Although our analysis cannot discriminate between a single power-law (unimodal) and a low-mass (<0.5MSun) tapered (bimodal) IMF, we can robustly constrain the fraction in low-mass stars at birth, that is found to increase from 20% at sigma0~100km/s, up to 80% at sigma0~300km/s. Additional constraints can be provided with stellar mass-to-light (M/L) ratios: unimodal models predict M/L significantly larger than dynamical M/L, across the whole sigma0 range, whereas a bimodal IMF is compatible. Our results are robust against individual abundance variations. No significant variation is found in Na and Ca in addition to the expected change from the correlation between [alpha/Fe] and sigma0. [Abridged]
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