In the modern digital landscape, the exponential growth of big data and the proliferation of advanced analytics present both unprecedented opportunities and significant challenges for cybersecurity. This review explores the imperative of enhancing cybersecurity protocols to safeguard sensitive information and ensure the integrity of digital infrastructures in an era characterized by vast data generation and sophisticated analytical techniques. As organizations across various sectors leverage big data to drive innovation and gain competitive advantages, they simultaneously face heightened risks from cyber threats. Advanced analytics, including machine learning and artificial intelligence, offer potent tools for detecting and mitigating these threats. However, the integration of such technologies into cybersecurity frameworks demands a comprehensive and forward-thinking approach. Key to this enhancement is the development of robust data governance policies that ensure data integrity, confidentiality, and availability. These policies must address the complexities introduced by diverse data sources, varied data formats, and the velocity at which data is generated and processed. Additionally, the implementation of machine learning algorithms can significantly improve threat detection capabilities by identifying patterns and anomalies indicative of cyber threats, thus enabling proactive defense mechanisms. Moreover, enhancing cybersecurity protocols involves the adoption of encryption techniques and secure communication channels to protect data both at rest and in transit. Continuous monitoring and real-time analytics are crucial for maintaining situational awareness and promptly responding to potential breaches. The utilization of big data analytics also facilitates the identification of vulnerabilities and the assessment of risk profiles, allowing for the prioritization of security measures based on threat severity and impact. Despite the technological advancements, challenges such as data privacy concerns, algorithmic biases, and the need for skilled cybersecurity professionals persist. Addressing these challenges requires a multi-faceted strategy encompassing regulatory compliance, ethical considerations, and ongoing education and training. In conclusion, enhancing cybersecurity protocols in the era of big data and advanced analytics is essential for protecting critical digital assets and maintaining trust in digital ecosystems. By integrating cutting-edge analytical tools and establishing comprehensive data governance frameworks, organizations can effectively mitigate cyber risks and leverage the full potential of big data for sustainable growth and innovation.