Recurrent Varicose Research Articles

Pelvic Venous Incompetence: Reflux Patterns and Treatment Results

To assess reflux patterns and the results of endovascular obliteration of ovarian veins in patients with symptomatic pelvic venous incompetence (PVI). A total of 71 female patients (mean age 49 years) with signs of PVI on selective phlebography of the pelvic veins were included in the study. In 53 cases (75%), recurrent varicose veins following previous surgery and stripping of the great saphenous vein were present and 51 patients (72%) were multiparous (> or = 2 children). Symptoms were scored on a visual analogue scale (VAS) assessing pelvic and lower limb pain. After duplex ultrasonography of the lower limb veins, in cases of suspected PVI, the presence of any reflux in the ovarian and pelvic veins was demonstrated by phlebography. In selected cases, endovascular treatment with embolisation was used. Follow-up assessment of symptoms was carried out at 1, 2 and 3 years. The left ovarian vein (OV) and the right internal iliac vein (IIV) were most frequently affected by reflux (n=41, 58% each). In about half the number of patients, reflux was demonstrated in more than one of the main pelvic veins (n=38, 54%). An extension of reflux into varicose veins of the groin or lower limb was demonstrated in 44 patients (62%); 35 patients (49%) received treatment for their PVI by coil embolisation. Fifty-five patients (77%) completed follow-up. Patients with isolated ovarian vein incompetence, who were treated by embolisation, experienced a significant improvement of symptoms (mean symptom score 5.2 standard deviation (SD) 3.5 before and 1.2 SD 0.9 after embolisation treatment; p<0.0001), while patients with untreated incompetence did not show improvement in symptoms (mean score 4.5 SD 1.6 before and 5.1 SD 1.5 after conservative treatment; non-significant (N.S.)). Improved symptoms were detected in patients with isolated IIV incompetence, who underwent embolisation treatment (mean symptom score 5.1 SD 2.5 before and 2.1 SD 1.6 after treatment; N.S.) although this did not reach statistical significance. Conservative treatment of patients with isolated IIV incompetence resulted in no relevant changes (mean score 4.2 SD 2.0 before and 4.5 SD 2.1 after treatment; N.S.). Worsening of symptoms was found in patients with combined reflux who underwent conservative treatment (mean score 5.3 SD 2.0 before and 6.5 SD 2.5 after treatment, N.S.). In case of combined OV and IIV reflux, isolated interventional treatment of incompetent ovarian veins did not improve symptoms at each interval of the follow-up (mean score 5.2 SD 2.1 before and 5.1 SD 2.6 after treatment, N.S.), while coiling of all reflux pathways resulted in symptom reduction; but this did not reach statistical significance due to the small numbers of patients (mean score 5.6 SD 2.2 before and 3.2 SD 2.1 after treatment, N.S.). Combined reflux in more than one pelvic vein is common. In these cases, isolated treatment of ovarian veins or conservative treatment is associated with a poor midterm clinical outcome. A clinical improvement was achieved only in patients with isolated ovarian vein incompetence.

Midterm results of the surgical treatment of varices by phlebectomy with conservation of a refluxing saphenous vein

A new physiopathologic concept within superficial venous insufficiency (SVI) describes ascending progression from the collaterals to the saphenous veins (SV), leading to a treatment that aims to remove the varicose reservoir and not the SVs. This study reports the midterm results of this therapeutic approach. This is a retrospective study of patients treated for varices by phlebectomy with conservation of a refluxing SV before July 2004. We evaluated the varicose reservoir by determining the number of zones to be treated (NZT); each lower limb was divided into 32 zones in the preoperative mapping. We performed a clinical and duplex ultrasound examination after 6 months and 1 year, and then once a year until year 4. Amongst 811 lower limbs operated on for first-time varicose veins, 303 in 221 patients (55 men; 166 women), mean age, 52.7 years (range, 20-93 years), were treated by phlebectomy, with conservation of a refluxing SV. All lower limbs operated on presented preoperative SV reflux >0.5 seconds: great SV (GSV), 85.8%; small SV (SSV), 11.9%; and GSV and SSV, 2.3%. The average NZT was 6.05 (range, 2-10). SV reflux was reduced to < 0.5 seconds in 69.6%, 69.2%, 68.7%, 68.0%, and 66.3% of limbs, respectively, after 6 months, 1, 2, 3, and 4 years of follow-up. Symptoms improved or disappeared in 84.2%, 84.2%, 83.4%, 81.4%, and 78.0% of limbs at each annual check-up until year 4. Freedom of varices recurrence was 95.5%, 94.6%, 91.5%, and 88.5%, respectively at 1, 2, 3, and 4 years. When the NZT was >7, the postoperative varicose recurrence was more frequent (odds ratio, 6.82; P = .0001), and the postoperative elimination of SV reflux was more frequent (odds ratio, 4; P = .037) as was symptoms improvement (odds ratio, 2.91; P = .004). When an ostiotruncal SV reflux extended to the malleolus preoperatively, the elimination of the SV reflux was less frequent (47.6% vs 70.3%; P < .05). Ablation of the varicose reservoir with conservation of a refluxing SV can be an effective treatment in the midterm for the signs and symptoms of SVI and leads to nonsignificant SV reflux in more than two of three cases. The extent of the varicose reservoir ablation is the key factor determining the hemodynamic and clinical efficacy of this more limited surgical approach.

Neovascularisation and Recurrence 2 Years After Varicose Vein Treatment for Sapheno-Femoral and Great Saphenous Vein Reflux: A Comparison of Surgery and Endovenous Laser Ablation

Neovascularisation is a major cause of recurrent varicosities following surgery. This prospective cohort study compares recurrence rates and the occurrence of neovascularisation following surgery or endovenous laser ablation (EVLA) for great saphenous vein reflux. 118 consecutive patients (72 female, 46 male, median age 48 [range 32-68 years]), 129 limbs were reviewed at a median of 24 months (range 18-30) after surgery (n=60 limbs) or EVLA (n=69 limbs) for primary sapheno-femoral and GSV reflux. Varicose vein recurrence, ultrasound detected groin neovascularisation and patient satisfaction (visual analogue scale) were recorded. Recurrence rates at 2 years were: surgery group 4/60 (6.6%; mid-thigh perforator n=2, residual GSV with neovascularisation n=2), EVLA group 5/69 (7%; GSV recanalisation n=3 (all received <50 J/cm laser energy), mid-thigh perforator n=1, new anterior saphenous vein reflux n=1) p=0.631. Neovascularisation was detected in 11/60 (18%) of the surgery group and 1/69 (1%) of the EVLA group, p=0.001. Patient satisfaction rates were 90% and 88% respectively (p=0.37). Although the frequency of recurrent varicosities 2 years after surgery and EVLA was similar, neovascularisation, a predictor of future recurrence, was less common following EVLA. Further, current recommendations on delivering > or =70 J/cm laser energy should reduce recanalisation rates and recurrence after EVLA.

Endoluminal thermal ablation versus stripping of the saphenous vein: Meta-analysis of recurrence of reflux

Catheter-based minimally invasive techniques developed to treat saphenous vein insufficiency include endovenous laser and radiofrequency ablation. Their long-term results are under evaluation. A meta-analysis of trials was performed, comparing endovenous versus surgical saphenous vein ablation with focus on long-term (greater than 365 days) outcomes of recurrence of varicosities, reflux and symptomatic disease. A systematic search of published studies reporting on the treatment of varicose veins was performed. The databases searched included Medline/PubMed, OVID, EMBASE, CINAHL, ClinicalTrials.gov, the Cochrane central register of controlled trials and the Cochrane database of systematic reviews. Search terms included saphenous vein ligation, stripping, radiofrequency ablation, laser ablation and endovenous ablation. Reports in all languages from 1966 to 2009 were considered. The 'related articles' function was used to broaden the search. All article titles, abstracts and subject headings were screened by one reviewer for potential relevance. Abstracts of articles selected by title were read online to reduce the number of articles for full-text examination. Finally, additional titles were sought in the bibliographies of the retrieved articles. Only studies reporting outcomes after more than 365 days were selected. Analyzed outcomes included recurrence of varicosities and reflux, as documented by duplex ultrasound, and recurrence of signs and symptoms. Data extraction was performed from life tables, text or graphs. Statistical analysis was performed using the commercially available software CMA Version 2 (Biostat Inc, USA). The random effects model was used to calculate the ORs and 95% CIs. Statistical heterogeneity was evaluated using the Q value and considered present if P<0.05. Eight randomized controlled trials were included; these reported on 497 patients. Two hundred twenty-six patients underwent ligation and stripping and 271 underwent endoluminal thermal ablation. The mean (± SD) follow-up period was 584±182 days. There was no difference in the age and sex distribution between the groups. There was no difference in the long-term recurrence rate between the two techniques (OR 0.97, 95% CI 0.48 to 1.9, P=0.9). Statistical heterogeneity was not significant (Q value P=0.5) and publication bias was limited. The analysis indicates that catheter-based treatments and traditional venous stripping with high ligation have similar long-term results. Establishing preoperative criteria for each method may improve outcomes but presently neither technique appears to confer an advantage in terms of mid- to long-term freedom from recurrent symptoms.

Venous valves and major superficial tributary veins near the saphenofemoral junction

Venous valves are still discussed controversially, mainly because it is still uncertain whether primarily missing or insufficient valves or the weakness of the venous walls cause varices. Furthermore, the distribution and frequencies of major superficial tributary veins (MSTVs), which should discharge the great saphenous vein (GSV) between the terminal (TV) and preterminal valve (PTV) gain in importance; a fortiori as remaining MSTVs during primary varicose vein treatment may be a reason of future recurrent varicose veins. Therefore, the aim of this study was to investigate both the frequency and position of the GSV valves and the distribution of MSTVs near the saphenofemoral junction (SFJ). We investigated 114 formalin fixed bodies with 217 GSVs. The measurement of the position of the valves and the entrances of the MSTVs was performed in situ from the SFJ to the nodule of the valve or to the orifice of the tributary vein into the GSV, respectively. On average, the specimens possessed 2.26 valves on the left side and 2.07 valves on the right side. First, valves were present in all 217 legs in a range of 0.0 to 7.2 cm. Taking as a basis the strict definition of a TV that it lies between the orifice of the GSV and the most proximal MSTV we could find only 75 TVs (68.8%) on the left side and 77 (71.3%) on the right side. In total, we found 803 MSTVs entering the GSV, an average of 3.7 veins per GSV. The left GSVs had significantly more MSTVs (P = .000). Most frequently, the superficial external pudendal vein (SEPV) existed in 90.3%, joining the GSV from medial 16.9 mm distally to the SFJ. A complete "venous star" of the MSTVs, as it is described in several textbooks, was present in only 18.4%. Terminal and preterminal valves of the GSV do not always exist. Using a strict definition whether a valve should be called either "terminal valve" or "preterminal valve", we will find a lot of them completely missing. This means that in a considerable number of patients reflux from the common femoral vein (CFV) to the GSV and further on into the MSTVs might occur. Several major superficial tributary veins join the GSV within the first millimeters; therefore a thorough exposition and monitoring of these vessels during diagnostic procedures are obviously crucial for a long-lasting success.

Pelvic vein reflux in female patients with varicose veins: comparison of incidence between a specialist private vein clinic and the vascular department of a National Health Service district general hospital

Mounting evidence suggests that pelvic vein reflux is an important contributing factor to recurrent varicose veins. We compared the incidence in our specialist private unit (Unit A) with that of a District General Hospital (Unit B). Results of all female patient lower limb duplex ultrasound (LLDUS) and transvaginal pelvic ultrasound (TVUS) scans performed over a one-year period were retrospectively reviewed. Patients with refluxing veins emanating from the abdomen or pelvis on LLDUS (non-saphenous reflux) routinely proceeded to TVUS in Unit A. In Unit A, non-saphenous reflux on LLDUS was present in 90-462 female patients (19.5%). In 81.1% of these, TVUS confirmed reflux in truncal pelvic veins (incidence 15.8%). In Unit B, non-saphenous reflux was present in 60-279 female patients (21.5%). One in five women presenting with varicose veins have reflux of non-saphenous origin. This is the case in specialist and non-specialist units. One in six has associated pelvic vein reflux.

VS08 ENDOVASCULAR VENOUS LASER VS OESCH PIN STRIPPER IN MANAGEMENT OF PRIMARY VARICOSITIES OF THE GREAT SAPHENOUS VEIN: A RANDOMIZED CONTROL TRIAL

Aim: Varicosities of the lower limb are a major economic and medical burden. Various modalities of treatment have been proposed. This study aims to compare minimally invasive Endovenous Laser Ablation (EVLA) with conventional High ligation and stripping using Oesch Pin stripper (HLS) in the management of primary varicosities of the Great Saphenous vein (GSV). Principal outcomes were abolition of GSV reflux and comparison of postoperative morbidity and mortality.Material and Methods: This trial was prospectively conducted over 2 years and comprised to a total of 60 consecutive consenting patients randomized (randomized by a random number assigned by a blinded person) equally between the EVLA and Surgery groups. The inclusion criteria were patients with symptomatic primary GSV reflux and varicosities suitable for both modalities of treatment. Exclusion criteria were secondary GSV varicosities and recurrent varicosities. All patients were followed up at regular interval for a period of 3 months.Results: GSV reflux was abolished in all patients in both groups. Patients with EVLA had a shorter length of stay (LOS) of 0.47 compared to 2.6 with HSL. One patient had minor burns with EVLA and in one venotomy had to be done due to slippage of guide wire. All other post‐operative complications such as haematoma, ecchymosis, and pain were significantly lower in the EVLA group. There was no mortality in either group.Conclusion: EVLA being an outpatient procedure resulted in a safer and quicker recovery and less socioeconomic burden with a shorter LOS, however the early peri‐operative pain was higher in the EVLA group. The long term results of recurrence have not been studied in this study and warrants further investigation.

Standard varicose vein surgery

This article examines the practice of standard varicose vein surgery including sapheno-femoral and sapheno-popliteal ligation, perforator surgery and surgery for recurrent varicose veins. The technique of exposure of the sapheno-femoral junction and the sapheno-popliteal junction is outlined and advice given on avoidance of complications for both. The evidence regarding methods of closure over the ligated sapheno-femoral junction is examined as is the requirement for stripping and the use of different types of stripper. The requirement to strip the small saphenous vein and the extent of dissection necessary in the popliteal fossa is also examined. Complications of standard varicose vein surgery are outlined. The frequency of wound infection, nerve injury, vascular injury and venous thromboembolism are listed and strategies to avoid these complications are examined.

First results with a new 1470-nm diode laser for endovenous ablation of incompetent saphenous veins

Most of the published EVLA data concern 810, 940, 980 nm diode lasers and 1064 or 1320 nm Nd:Yag laser systems. Major side effects are postoperative pain and bruising. The aim of this study was to show the outcome one year after EVLA of incompetent saphenous veins with a 1470 nm Diode laser (Ceralas E, biolitec). Between December 2006 and February 2007, 134 saphenous veins (108 GSV, 26 SSV) in 117 legs of 100 consecutive patients where treated by EVLA for GSV and SSV incompetence. All patients were examined clinically and with duplex by an experienced phlebologist prior to intervention, and at the follow-up visits for complications, occlusion, flow and reflux in the treated vein segment. The clinical evaluation included clinical CEAP and the presence of recurrent varicose veins. Patient satisfaction was assessed by a 0 to 4 scale. After a mean follow-up period of 184 days (SD 27) 127 treated veins (102 GSV, 25 SSV) of 111 limbs in 94 patients and after 329 days (SD 14) 105 treated veins (94 GSV, 21 SSV) of 105 limbs in 83 patients were reinvestigated. Six patients were lost to follow up after six months and an additional 11 patients after one year. Up to one year follow-up all treated veins remained occluded. At six months, one new insufficient anterior accessory saphenous vein (AASV) and after 12 months, three new insufficient AASV occurred. After one year 45 patients were very satisfied with the method, 34 were satisfied, three were fairly and one was not satisfied. The mean of all answers was 0.5 (SD 0.5). In three cases phlebitic reactions after 10 days, but no severe complications such as deep vein thrombosis occured. After six months in 9.5% of the legs paresthesia was present in the treated area which reduced to 7.6% after one year. Intake of painkillers was mean 6.7 tablets (SD 3.5). When we compared GSV legs treated with LEED below or above 100 J/cm, the paresthesia rate was significantly lower in the first group with 2.3% compared to 15.5 % in the higher LEED group. The differences for number of days with analgesic intake and for the paraesthetic area were significant. Discussion In this prospective follow-up study with 100 consecutive patients and 134 treated saphenous veins a high occlusion rate of 100% could be demonstrated one year after treatment. However, with LEED > 100 J/cm in this study, the incidence of paresthesia rose significantly. Therefore it seems adequate to stay below 100 J/cm in the future as the occlusion rate was the same below and above 100 J/cm. EVLA of GSV and SSV with a 1470 nm diode laser is a minimally invasive, safe and efficient therapy option with a high success rate.

Veins along the course of the sciatic nerve

To describe the anatomic variations, symptomatology, and pathophysiology associated with the sciatic nerve (SN), and report the results after treatment of the incompetent veins. Retrospective analysis of prospectively collected data from patients with signs and symptoms of chronic venous disease that had superficial varicosities associated with incompetent veins along the SN. Patients were evaluated with duplex ultrasound scans. In patients with enlarged veins along the SN, the anatomy of the incompetent veins, their size and association with superficial varicosities, and the severity of insufficiency were analyzed. The symptoms associated with their presence and the treatment results were also noted. Patients were re-evaluated following treatment for recurrence of varicosities and symptoms. We identified 24 limbs in 21 patients with varicosities along the SN and its branches. The duration of signs and symptoms was 4.5 years ranging from 1 to 14. Reflux was detected in 18 veins of the SN, in three persistent sciatic veins and in three veins of the tibial nerve. All limbs with sciatic and tibial nerve veins had varicosities in the lateral and posterior aspect of thigh and calf and were symptomatic. Ten limbs presented with CEAP class 2, 5 with class 3, 2 with class 4, and 1 with class 1. Pain or tingling was reported in 15 limbs, itching in 8, and heaviness in 7. The distribution of pain and tingling was present along the nerves in 19 limbs. One patient had acute thrombosis in a persistent sciatic vein and died from pulmonary embolism. Of the 21 limbs with SN veins, 16 were treated with subfascial vein ligation and phlebectomies. Three patients had sclerotherapy, 1 refused treatment, and 1 had mild symptoms not requiring treatment. Of the 19 treated limbs, in 11 there was relief of their symptoms, 6 had significant improvement, and 2 had no change. Within a year, 4 patients required additional treatment for veins along the same area. Eleven limbs had a follow-up duplex scan 3 to 19 months after their treatment. All limbs showed significant diameter reduction in the nerve veins while mild reflux was present in 3 (4.1 mm vs 2.1 mm, P < .001). Reflux is the most common pathology of the sciatic and tibial nerve veins which produces significant symptoms along the distribution of the nerves. Treatment of the varicosities offers significant relief while recurrence or residual varicosities are easily managed.

REVAT (Recurrent Varices After Treatment)

SummaryThe term “recurrent varicose veins” covers various entities. In the first instance, recurrent varicose veins may be the progression of the underlying disease, as there is a hereditary disposition to the condition, but we also find the phenomenon of neovascularisation, and lastly we repeatedly see recurrent varices as a result of technical or strategic surgical errors and the failure of endovenous procedures. No differentiation between these different types of recurrent varicose veins has previously been made in the literature, so that the numbers given vary between 6% and 60%. Up to the present time, few data on the progression of the underlying disease are to be found in the literature. Our own studies, on average 36 months postoperatively, demonstrated new varicose side branches that could be interpreted as progression of the underlying disease in 56.8% of the patients followed up.Several recent publications demonstrate neovascularisation as a cause of recurrence. While some authors give a figure of 24% for recurrence due to neovascularisation in patients who have had surgery, other publications regard neovascularisation as the main cause of postoperative recurrence.The data on technical or strategic surgical errors and recanalisation after endovenous procedures are also very varied. Numbers for technical errors as the cause of recurrent varicose veins following surgery range from 10.7% to more than 70%. Published recanalisation rates after endovenous laser therapy vary between 0% and 36%; the average recanalisation rate in the available prospective randomised studies on radiofrequency obliteration was 12.9%. Foam sclerotherapy has recanalisation rates between 69% and 86%, with a mean follow-up of 32.2 months.Given the different possible causes, it is extremely important, that recurrent varicose veins should be classified. The authors have developed a simple classification that can be used in routine daily practice. Recurrent varicose veins are given the acronym REVAT (recurrent varices after treatment). Generally speaking, on the one hand there is progression of the underlying disease (progression of disease = PD) and, on the other hand, varicosities after treatment as a result of technical error or failure of the method used (recurrence after treatment = RT). Progression of the underlying disease can be further subdivided into neovascularisation at the saphenofemoral or popliteal junction (progression of disease at the junction = PD-J) and new varices arising in the treated vascular territory (progression of disease at the limb = PD-L).In the case of recurrent varices after treatment we distinguish between a persisting or a new reflux at the saphenofemoral or the popliteal junction (recurrence after treatment at the junction = RT-J), untreated segments of the great or small saphenous veins or recanalisation of the trunk (recurrence after treatment at the trunk = RT-T) and untreated side branches or perforating veins (recurrence after treatment at side branches = RT-S). With the help of these abbreviations a simple formula can be generated to describe the recurrent varices, e.g. recanalisation of the left great saphenous vein (GSV) after endovenous treatment and a new varicosis in the vascular territory of the left great saphenous vein resulting from progression of the underlying disease: vascular territory left great saphenous vein = GSV-L, technical or tactical error due to recanalisation of the GSV = RT-T, progression of the underlying disease in the vascular territory of the GSV = PD-L. This generates the formula: GSV-L : RT-T, PD-L.Since there are no exact figures on the incidence of the individual causes of recurrent varicosis, a classification of recurrent varicosis is indispensable to ensure clarity in the future.

Veias linfonodais: uma causa pouco conhecida de varizes

As veias linfonodais fazem parte de uma rede venosa no triângulo de Scarpa, que liga em vários pontos o sistema venoso superficial às veias profundas, e podem tanto ser causa de incompetência do sistema venoso superficial quanto estar envolvidas na recorrência pós-safenectomia. Na rotina diária dos exames de Doppler venoso de membros inferiores, temos notado de maneira cada vez mais freqüente a associação das veias linfonodais com varizes primárias e recorrentes. A adequada caracterização dessas veias pode ajudar na compreensão do mecanismo fisiopatológico do aparecimento das varizes e permitir um controle e tratamento mais dirigidos. Este artigo lança luz sobre os aspectos anatômicos e fisiológicos das veias linfonodais, objetivando chamar a atenção dos profissionais envolvidos no diagnóstico de doenças venosas dos membros inferiores para uma causa pouco difundida de varizes.

Endovenous Ablation of the Saphenous Vein

The introduction of the minimally invasive, endovenous thermal techniques of superficial reflux ablation have revolutionized the treatment of varicose veins in the last 8 years. The ease of performance even in an office setting, reduced discomfort, and quicker return to normal activity have resulted in universally superior patient acceptance and have made these endovenous procedures the mainstay of present treatment of varicose veins. With encouraging early and mid-term results, future developments in this field must mandate standardization of technical aspects, follow-up imaging, and reporting. The significance of reflux in the great saphenous vein stump, of reflux-free recanalization of a segment of the vein, and their potential for causing recurrent varicose veins remains unknown. The incidence of groin neovascularization and its significance needs to be determined. Ultrasound-guided foam sclerotherapy is also emerging as a competitor to other endovenous techniques and is particularly useful in superficial and tortuous veins not ideally suited for endovenous thermal ablation, as well as recanalized segments of ablated veins.

Randomised Trial of Flush Saphenofemoral Ligation for Primary Great Saphenous Varicose Veins

Objectives: The aim of this study was to assess different techniques of saphenofemoral ligation in the treatment of primary varicose veins. Methods: One hundred and eighty-two patients (210 legs) with primary saphenofemoral junction incompetence were randomised to standard saphenofemoral ligation (transfixion with an absorbable suture) (SSL) or flush saphenofemoral ligation (oversewing with 4/0 polypropylene) (FSL). All legs underwent additional great saphenous vein stripping and multiple phlebectomies. Patients underwent assessment preoperatively, and at 6 weeks, 1 year and 2 years postoperatively with clinical examination, duplex imaging and completion of the Aberdeen Varicose Vein Symptom Severity Score (AVVSSS). Results: A total of 148 patients (172 legs) attended follow-up at 2 years postoperatively. Recurrent varicose veins were visible in 30 legs (33 per cent) in the SSL group and 26 legs (32 per cent) in the FSL group (P = 0.90). Neovascularisation was present in 20 groins (22 per cent) in the SSL group and 15 groins (19 per cent) in the FSL group (P = 0.57). Nine cases of neovascularisation in the SSL group and five in the FSL group directly resulted in clinical recurrence (P = 0.37). Conclusions: Flush ligation of the saphenofemoral junction confers no advantage over standard ligation with respect to clinical recurrence and neovascularisation. Registration number: ISRCTN20235689 (http://www.controlled-trials.com).

Randomized clinical trial comparing endovenous laser with cryostripping for great saphenous varicose veins

The aim of this randomized single-centre trial was to compare the 2-year results of endovenous laser ablation (EVLA) and cryostripping for varicose veins. A total of 120 patients with uncomplicated great saphenous varicose veins were randomized equally to one of the two treatments. Principal outcomes measures were: freedom from recurrent varicose veins on duplex imaging, and improvement in Venous Clinical Severity Score (VCSS) and Aberdeen Varicose Vein Severity Score (AVVSS) 6, 12 and 24 months after treatment. Life-table analysis showed overall freedom from recurrent incompetence at 2 years in 77 (95 per cent confidence interval (c.i.) 72 to 78) per cent of patients after EVLA and in 66 (95 per cent c.i. 60 to 67) per cent after cryostripping (P = 0.253). VCSS and AVVSS values improved significantly after treatment, but the differences between the treatments were not significant. EVLA provided significantly more favourable results than cryostripping with respect to duration of operation, postprocedural pain, induration and resumption of normal activity. EVLA and cryostripping were similarly effective in patients with varicose veins, but patients favoured EVLA because of less pain and postoperative morbidity, and quicker return to normal activity. ISRCTN33832691 (http://www.controlled-trials.com).

Randomised Trial of Flush Saphenofemoral Ligation for Primary Great Saphenous Varicose Veins

ObjectivesThe aim of this study was to assess different techniques of saphenofemoral ligation in the treatment of primary varicose veins. MethodsOne hundred and eighty-two patients (210 legs) with primary saphenofemoral junction incompetence were randomised to standard saphenofemoral ligation (transfixion with an absorbable suture) (SSL) or flush saphenofemoral ligation (oversewing with 4/0 polypropylene) (FSL). All legs underwent additional great saphenous vein stripping and multiple phlebectomies. Patients underwent assessment preoperatively, and at 6 weeks, 1 year and 2 years postoperatively with clinical examination, duplex imaging and completion of the Aberdeen Varicose Vein Symptom Severity Score (AVVSSS). ResultsA total of 148 patients (172 legs) attended follow-up at 2 years postoperatively. Recurrent varicose veins were visible in 30 legs (33 per cent) in the SSL group and 26 legs (32 per cent) in the FSL group (P=0.90). Neovascularisation was present in 20 groins (22 per cent) in the SSL group and 15 groins (19 per cent) in the FSL group (P=0.57). Nine cases of neovascularisation in the SSL group and five in the FSL group directly resulted in clinical recurrence (P=0.37). ConclusionsFlush ligation of the saphenofemoral junction confers no advantage over standard ligation with respect to clinical recurrence and neovascularisation.Registration number: ISRCTN20235689 (http://www.controlled-trials.com).

Duplex ultrasound changes in the great saphenous vein after endosaphenous laser occlusion with 808-nm wavelength

Endosaphenous laser ablation is used in the treatment of great saphenous vein insufficiency with various methods, with and without surgical interruption. However, its mode of action and indications are not yet clear. To verify the mode of action of endosaphenous laser ablation by duplex ultrasound (DUS) follow-up, with the support of histologic observations of eight cases, 44 of 182 affected limbs (CEAP C2 to C6) were selected for intravenous laser ablation of the great saphenous vein. Saphenofemoral junction incompetence was treated by surgical interruption. An 808-nm diode laser (Eufoton, Trieste, Italy) was used (variable pull-back velocity, 1 to 3 mm/s; power, 12 to 15 W; energy, 30 to 40 J/cm). In eight limbs the venous fragments were studied under light microscopy at 5 minutes and after 1 and 2 months. In 44 limbs DUS and clinical examinations were performed from 7 days to 1, 2, 6, and 12 months. Variously organized thrombi containing necrotic inclusions and patent areas were observed in the vein lumen. Neither neovascularization nor thrombus extension were detected at the groin by DUS examination. Progressive venous diameter decrease and thrombus fibrotic transformation up to the hypotrophic venous disappearance at 12 months were followed up (P < .00001). Not occluded (18.8%), recanalized short segments (22.7%), two entirely recanalized saphenous veins with varicose recurrence (4.5%), and postoperative phlebitis (13.6%) were observed. Nonocclusions and phlebitis prevailed in the larger veins (P < .05). The healing process is based on vein thrombosis, fibrosis, and venous atrophy. Saphenofemoral interruption makes venous occlusion easier and prevents potential thrombotic complications and recurrence by recanalization. DUS monitoring makes possible to follow-up the thrombus involution and perform early retreatment. The 808-nm endosaphenous laser should be mainly applied to veins of <10 mm in diameter.

A prospective evaluation of the outcome after small saphenous varicose vein surgery with one-year follow-up

The aim was to examine the effect of various surgical maneuvers during standard surgery for small saphenous varicose veins (SSV). This was a prospective cohort study of patients that underwent small saphenous varicose vein surgery. Two-hundred nineteen consecutive patients (234 legs) with isolated primary or recurrent small saphenous varicose veins undergoing surgery were enrolled in a multicenter study involving nine vascular centers in the United Kingdom. Operative technique was determined by individual surgeon preference; clinical and operative details, including the use of stripping, were recorded. Clinical examination (recurrence rates) and duplex imaging (superficial and deep incompetence) were evaluated at six weeks and one year after surgery. A total of 204 legs were reviewed at one year; 67 had small saphenous varicose vein stripping, 116 had saphenopopliteal junction (SPJ) disconnection only, and the remainder had miscellaneous procedures. The incidence of visible recurrent varicosities at one year was lower after SSV stripping (12 of 67, 18%) than after disconnection only (28 of 116, 24%), although this did not reach statistical significance. There was no significant difference in the rate of numbness at one year between those who had SSV stripping (20 of 71, 28%) and those who had disconnection only (38 of 134, 28%). The rate of SPJ incompetence detected by duplex at one year was significantly lower in patients who underwent SSV stripping (9 of 67, 13%) than in those who did not (37 of 115, 32%) (P < .01). Stripping of the SSV significantly reduced the rate of SPJ incompetence after one year without increasing the rate of complications.

Residual Stumps Associated with Inguinal Varicose Vein Recurrences: A Multicenter Study

Purpose It is unclear whether a residual sapheno-femoral stump left in place after stripping of the great saphenous vein can contribute to the formation of late inguinal varicose vein recurrence. In order to obtain information about the time course of recurrence development, patients with histologically proven residual stumps were recruited and asked about the interval between the initial operation and the first clinical signs of varicose vein recurrence. Methods A multi-centre study involving 7 centres was conducted amongst patients undergoing redo-surgery for inguinal varicose vein recurrences. The sapheno-femoral stumps resected during the redo-surgery were classified histologically. Patients with a proven long residual sapheno-femoral stump were asked to describe the first signs of varicose vein recurrence with the help of a standardised questionnaire. From these data the symptom-free interval, consisting of the time frame between the initial operation and the first signs of recurrence, was determined. Results In 279 legs of 251 patients a long residual sapheno-femoral stump was present. Most patients had experienced a symptom-free interval after the initial operation with a mean duration of 7.4 S.D. 5.5 years. Recurrent varicose veins became apparent after a mean time interval of 6.3 S.D. 5.3 years and congestion symptoms occurred after a mean interval of 8.5 S.D. 5.7 years. Conclusions In patients with symptomatic groin recurrences, a long residual sapheno-femoral stump was found in about two thirds of cases. The first clinical signs of varicose vein recurrence can be expected 7–8 years after the initial treatment at the earliest. Long term follow up is required reliably to asses the outcome of treatment for varicose veins.

Venous Disease Simplified

This concise book features contributions from an impressive array of experts nearly all working in the UK who each review some aspect of venous disease. Most of the important topics are discussed and the salient facts presented. Some of the contributions presuppose a degree of familiarity with the subject but this varies from article to article. The initial chapter by Lane summarises developments in the study of venous disease from 1552 BC to the present day. The next chapter discusses the classification of venous disease and the various factors thought to play a role in the aetiology of varicose veins and leg ulcers. Many patients are convinced that genetics play an important role in the development of varicose veins. Although this is open to debate, Fowkes disappointingly simply suggests more research. Contributions from Bradbury et al. and Lees take us swiftly through the clinical diagnostics of venous problems. Then Davies with his co-workers shows in two chapters how we can improve quality of life with treatment but questions who should pay. The results of the recent randomised and economic assessment of conservative and therapeutic interventions for varicose veins (REACTIV) trial on the economic benefit of treatment of varicose veins are, unfortunately, not discussed though the inclusion of the internet address of the NHS Health Technology Assessment website does allow the results to be tracked down by a determined reader. The short chapter by de Cossart on ‘minimising complications, complaint and litigation’ could be usefully read by every doctor, not just junior surgeons. The tabular format is very clear and it sets out to ‘offer ideas on what should be in the mind of the practitioner at each step of the patient's journey’. It also reminds us of the myriad of questions we should be asking ourselves all the time as we see and treat each individual patient. Earnshaw then discusses recurrent varicose veins and introduces the modern minimally invasive methods of treatment before substantive chapters on these new techniques. The later thoughtful contributions from Whitely and Coleridge Smith on newer methods of venous obliteration will benefit anyone contemplating introducing these techniques into their own surgical armamentarium. Chapters from Stansby on subfascial endoscopic perforator surgery, Vandendreissche on sclerotherapy and Caprini on venous thrombo-embolism reflect their respective authors' interests while Tan and Burnand tell us about deep venous surgery. Two useful chapters from Cheltenham General Hospital's leg ulcer unit on nurse-led clinics by Taylor and Sim, and venous leg ulcer services by Whyman et al. are followed by advice from Scurr on deep venous thrombosis and travel. Inevitably in a compact collection of individual reviews, there will be some subjects that have been omitted and so there are some suggestions for improvement for a subsequent edition. It is a pity that developments in dressings and hosiery for venous ulcers are not covered particularly well, while the new technique for venous valve reconstruction developed by Maleti and Lugli is not even mentioned. The monograph would also surely have benefited from colour illustration. The only serious criticism I have is the lack of any index to guide the reader to a key fact or find a new technique (nor any CD to search). Despite this drawback, the book is a simple, concise and useful summary of current approaches to venous disease.