Varicella Research Articles

Leveraging convolutional neural networks and hashing techniques for the secure classification of monkeypox disease

The World Health Organization declared a state of emergency in 2022 because of monkeypox. This disease has raised international concern as it has spread beyond Africa, where it is endemic. The global community has shown attention and solidarity in combating this disease as its daily increase becomes evident. Various skin symptoms appear in people infected with this disease, which can spread easily, especially in a polluted environment. It is difficult to diagnose monkeypox in its early stages because of its similarity with the symptoms of other diseases such as chicken pox and measles. Recently, computer-aided classification methods such as deep learning and machine learning within artificial intelligence have been employed to detect various diseases, including COVID-19, tumor cells, and Monkeypox, in a short period and with high accuracy. In this study, we propose the CanDark model, an end-to-end deep-learning model that incorporates cancelable biometrics for diagnosing Monkeypox. CanDark stands for cancelable DarkNet-53, which means that DarkNet-53 CNN is utilized for extracting deep features from Monkeypox skin images. Then a cancelable method is applied to these features to protect patient information. Various cancelable techniques have been evaluated, such as bio-hashing, multilayer perceptron (MLP) hashing, index-of-maximum Gaussian random projection-based hashing (IoM-GRP), and index-of-maximum uniformly random permutation-based hashing (IoM-URP). The proposed approach’s performance is evaluated using various assessment issues such as accuracy, specificity, precision, recall, and fscore. Using the IoM-URP, the CanDark model is superior to other state-of-the-art Monkeypox diagnostic techniques. The proposed framework achieved an accuracy of 98.81%, a specificity of 98.73%, a precision of 98.9%, a recall of 97.02%, and fscore of 97.95%.

Prediction of lumpy skin disease virus using customized CBAM-DenseNet-attention model

Lumpy skin disease virus (LSDV) is an extremely infectious, viral, and chronic skin disease that is caused by the Capripox virus. This viral disease is predominantly found in cows. Mosquitoes and ticks are the primary transmitters for the spread of this virus. Recently, LSDV has been rapidly spreading all over the world, especially in several areas of Pakistan, India, and Iran. Thousands of cows have died due to this infectious virus in Pakistan and early detection of LSDV is needed to avoid further loss. The prediction and classification of LSDV are hindered by the lack of publicly available datasets. Despite a few studies using LSDV datasets, such datasets are often small, which may lead to model overfitting. In this regard, we collect the dataset from several online sources, as well as, collecting images from veterinary farms in different areas of Pakistan. Deep learning has been widely used in the medical field for disease detection and classification. Therefore, this study leverages DenseNet deep learning models for LSDV detection and classification. Experiments are performed using VGG-16, ResNet-50, MobileNet-V2, custom-designed convolutional neural network, and Inception-V3. The DenseNet architecture presents a Convolutional Block Attention Module (CBAM) and Spatial Attention (SA) for the prediction and classification of LSD. Results demonstrate that a 99.11% accuracy can be obtained on the augmented dataset while a 94.23% accuracy can be achieved with the original dataset for chicken pox, monkey pox, and LSDV. Comparison with state-of-the-art studies corroborates the superior performance of the proposed model.

Assamese Cultural Narratives of Health, Illness and Healing

This present study was undertaken to understand the existing Assamese society beliefs and practices in relation to various illnesses such as jaundice and chicken pox. A purposive or judgmental sampling technique was adopted to select the subjects for the study. Data was collected from elderly subjects who had good knowledge about indigenous beliefs and practices of health and illnesses with the age group for the study considered at 50 and above for both genders. From the study, we find that most of the people strongly believed that health related issues can be cured with all the traditional form of practices or home remedies. The study found numerous believes and practices where some are safe and have scientific validation while some do not. We also find that these practices have been prevalent since time immemorial in the Assamese society, to the point that people tend to seek solutions from local ‘medicinemen’ rather than visit modern doctors. Though some practices have scientific validation, some are purely based on superstitious beliefs and might cause more harm than good if there are not enough interventions to remove ignorance among the people still adhering to such practices.

Severe Antiphospholipid Syndrome in a Child with Chicken Pox: Clinical Case

Background. Antiphospholipid syndrome develops at autoimmune diseases, pregnancy, or genetic predisposition, and it is characterized by high risk of thrombosis in arterial, venous, and capillary vessels. This syndrome in children is rare, and necrotic skin lesions occur in the most extreme cases. Clinical case description. A child, 1 year old, with chicken pox has developed hemorrhagic rash on his back, swelling of the left shoulder and forearm on the 4th day of the disease. Medical treatment included acyclovir, ceftriaxone, sodium heparin. Aggravation of hemorrhagic rash over the body, spread of edema from the left shoulder to upper arm and neck, formation of flaccid bubble and necrosis locus (75 cm) on the outer upper third of the left shoulder were noted on the 5th-6th day. Increase in the levels of antibodies to 2-glycoprotein I (IgG — 48.9 U/ml, IgM — > 100 U/ml) and cardiolipin (IgM — 73.0 U/ml) was revealed. The diagnosis “antiphospholipid syndrome” was established. All necrotized tissues were removed on the 11th day, and the wound defect (86 cm) was subsequently covered by mesh skin grafts. The levels of antibodies (IgG + IgM) to 2-glycoprotein I remained high, 45.2 U/mL, 12 weeks after the onset of the disease. Thus, it has confirmed the development of antiphospholipid syndrome. The child continued treatment with warfarin (3.75 mg/day) with INR control. Conclusion. Hemorrhagic skin lesions in children with infectious diseases requires laboratory diagnostics of antiphospholipid syndrome, early prescription of anticoagulant and antiplatelet therapy, and surgical support.

Vaccination of Adolescents as an Important Way to Preserve Demographic Nation's Potential

Relevance. Currently, adolescents are protected against 8 infections within the framework of the National Vaccination Schedule: tuberculosis, viral hepatitis B, diphtheria, tetanus, measles, rubella, mumps and influenza (annually). Post-vaccination immunity to whooping cough, acquired in the first years of life, begins to decline since 4–7 years. In recent decades, there has been an increase in the incidence, including among adolescents, of such pathogens as Neisseria meningitidis, Streptococcus pneumoniae, Bordetella pertussis, strains of the human papillomavirus (HPV) of high oncogenicity, the herpes zoster virus and etc., that affect the creation of the foundation of future health nation. Aim. To substantiate the vaccination strategy for adolescents as one of the most important factors for creating the demographic security of the nation. Results. The burden of infectious pathologies of meningococcal, pneumococcal etiology, pertussis, HPV and herpes Zoster, its impact on the development of the health of adolescents in Russia and the intended tactics for implementing vaccination of young people with the help of modern immunobiological drugs are shown. Conclusion. Vaccination of adolescents against infections such as meningococcal and pneumococcal infections, whooping cough, chicken pox, and HPV is a strategic task, since reducing the risk of contracting infectious diseases in this age group directly affects the preservation of the demographic potential of the nation

Injuries of the oral mucosa. Clinical cases

Background. Often with some infectious diseases, in addition to the typical manifestations, characteristic inflammatory changes are observed on the mucous membranes, which can imitate the course of other diseases. The purpose was to remind dentists and general practitioners about the importance of differential diagnosis of lesions of the oral mucosa in infectious and non-infectious pathologies on the example of clinical cases. Materials and methods. We conducted an empirical, descriptive study of 3 clinical cases of lesions of the oral mucosa in children who underwent inpatient treatment at the Kyiv City Children’s Clinical Infectious Hospital in 2023–2024. Results. In the first clinical case, the manifestation of type 1 diabetes was described, which was accompanied by oral candidiasis that was previously regarded as a suspicion of measles. The second clinical case demonstrates aphthous ulcers in HIV infection, which was previously mistaken for acute tonsillitis in a child. The third case described enteroviral vesicular stomatitis, which by the nature of the elements resembled chicken pox. Conclusions. Lesions of the oral mucosa can mimic the manifestations of common infectious and non-infectious diseases. Therefore, differential diagnosis of lesions of the oral mucosa is extremely important in various fields of medicine and dentistry.

RISK FACTORS FOR THE DEVELOPMENT OF PLACENTAL DYSFUNCTION ON THE BACKGROUND OF PREGNANT WOMEN GENITAL INFECTIONS

The progress of perinatology revealed new problems related to the gestational process and antenatal protection of the fetus. Among indicators of perinatal morbidity in modern conditions, one of the leading places occupied by placental dysfunction, the frequency of which, according to the data of domestic and foreign scientists ranges from 36% to 60%. It is known that among the many factors that affect the complicated course of pregnancy and perinatal morbidity, infectious factors in modern conditions occupy one of the leading places. Despite certain achievements in elucidating the etiological factors and pathogenesis of the development of placental dysfunction (PD), the issues of diagnosis and treatment of this pathology in pregnant women need further improvement. Thus, the study of links in the pathogenesis of manifestations of placental dysfunction, which develops during pregnancy in the early stages of gestation against the background of genital infections, is relevant and promising.The purpose. To assess the risk factors for the development of placental dysfunction in pregnant women with genital infections.Material and methods. The retrospective comparative study included 55 women who gave birth after involuntary childbirth according to the regional perinatal center of Chernivtsi, who had signs of placental dysfunction and genital infections during pregnancy during the period 2021-2022.Research results. One of the most important factors affecting the fetoplacental system, which leads to the development of chronic PD (CPD), are infections of the TORCH group. Infections during pregnancy, depending on the gestational period, lead to miscarriage, abortion, stillbirth, malformations of the child, cerebral defects, as well as to acute and chronic neonatal diseases. We conducted a retrospective analysis of risk factors, the frequency and structure of obstetric complications based on the data of 55 birth stories of the regional perinatal center in Chernivtsi for 2021-2022. Manifestations of placental dysfunction against the background of genital infections were studied at different gestational periods. Placental dysfunction occurs at different gestational periods in women of different ages. However, in young people (up to 18 years old) it occurs less often at all stages of gestation, compared to other age categories. A significant number of pregnant women with manifestations of placental dysfunction suffered from infectious diseases in childhood (measles, chicken pox, acute respiratory and viral infections, angina, various disorders of menstrual function (hyperpolymenorrhea, hypomenstrual syndrome, algodysmenorrhea) were quite often observed in pregnant women with manifestations of placental insufficiency. More often, placental dysfunction develops during first births than during repeated births. Cases of stillbirth, spontaneous miscarriages, artificial abortions and ectopic pregnancies often occur in the anamnesis. A number of authors [41] indicate that pregnant women with manifestations of placental insufficiency often experience various complications of the current pregnancy. Modern scientific studies show that almost 80% of pregnant women with genital infections show significant changes in the immune, endocrine and coagulation systems, which lead to a violation of the formation of the fetoplacental complex and a violation of adaptation mechanisms in the mother-placenta-fetus system.Conclusion. Clinical and statistical analysis shows the negative impact of manifestations of genital infections in different gestational periods on the course of pregnancy and the state of the fetus and newborn. The conducted studies on this issue give reason to talk about the need to review the system of obstetric tactics for these pregnant women, and further improvement of medical measures for antenatal protection of the fetus with this complication of pregnancy.

Prevalence of Lassa Fever Infections in Ondo State, Nigeria

Emerging and re-emerging infectious diseases have been of immense threat to public health in this 21st century. Among these diseases are COVID-19, Lassa fever, monkeypox, yellow fever, ebola, chicken pox disease and many others. Out of all the above mentioned diseases, Lassa fever is the most recurrent and trending infectious disease in Nigeria which affects many states. It is of great concern that Ondo State is one of the major epicentres of the virus. The objective was to examine the incidence of Lassa fever in Ondo State, Nigeria. A descriptive research design using a purposive sampling technique was used to collect data. Findings revealed that in 2018, Ondo State accounted for 25% of total Lassa fever incidence cases in Nigeria, which suggests that Ondo State was one of the major epicentres of the virus in 2018. As of March 19, 2022, the figure rose to 28% of total Lassa fever incidence. This implies that Ondo State was also the major epicentre of the virus as of March 19, 2022. Furthermore, in the 42nd week of 2022, the predominant age group of the patients affected by Lassa fever in Ondo State was 21–30 years. There has been a significant increase in the number of suspected and confirmed cases as compared with 2021. The factors contributing to the reemergence of LF epidemics in Nigeria are nosocomial transmission, travel and migration, the public health system, socio-cultural factors, conflicts and the COVID-19 pandemic. In conclusion, health education of indigenous people at the community levels (especially residents of Owo and Ose Local Government Areas) about LF causes, preventive measures and avoidance of cultural practices that could predispose them to Lassa fever infection should be given priority. Also, case management capacity and contact tracing must also be strengthened through the establishment of well-equipped and dedicated treatment/referral centers in the epicentre. Training and re-training of clinical care teams should also be given priority.

Pemberdayaan Ibu-Ibu Rumah Tangga Dalam Upaya Meningkatkan Ekonomi Keluarga Melalui Pengolahan Keripik Gedebog Pisang

Poverty is one of the major problems faced by Indonesia because human needs and desires are increasing and becoming more diverse from day to day, as are household needs. One indicator for increasing welfare is by increasing empowerment of women, especially housewives. Through productive household business activities such as producing chips from banana stems, Business opportunities selling home-cooked food or chips from banana stems are still very much in demand among the community, besides this business is also not difficult to do because housewives can do this activity in the gaps of being busy as housewives, and the raw materials do not have to be bought again at the traditional market because they are already available in the garden or in the yard. Banana plants only bear fruit once and then die so the banana plants that have been harvested will be cut down and replaced with new banana shoots. Banana stems that come from the remaining harvest are usually not used or processed so that they pile up and cause an unpleasant odor for the community. In fact, banana stems have good content for the human body such as being able to prevent an increase in blood sugar levels and improve the digestive system by having daily fiber intake, banana stems can also support diet programs because they can make you full, banana hearts can also reduce postpartum fever, treat intestinal ulcers, treat chicken pox, can prevent kidney stones, reduce stomach acidity levels, and cure infections, and there are many more benefits of banana stems that are not yet known by the community

An Analytical Study of the Number of Communicable Diseases and Health Institutions in Iraq using Two-Way Analysis of Variance, Friedman and Scheffe Tests

In this research paper, data were analyzed from Environmental Statistics in Iraq (Health Indicators for 2019)/ Central Statistical Organization /Iraqi Ministry of Planning. The data represents the number of health institutions distributed across all governorates of Iraq (government hospitals, private hospitals, popular clinics, specialized health centers (dental, chest, allergy, asthma, other specialties), primary health care centers (main and subsidiary), other health institutions (insurance clinics). health care, health homes), training health center, family medicine health center, family planning center, central health laboratories, forensic medicine, blood bank). In addition to other data representing the number of infections with communicable diseases in Iraq (polio, acute flaccid paralysis, whooping cough, measles, German measles, mumps, congenital tetanus, adult tetanus, hydatid cysts, typhoid, malaria, schistosomiasis, bacillus dysentery, rabies, Diphtheria, chicken pox, hemorrhagic fever, Malta fever, pneumonia, cholera, scabies, cutaneous leishmaniasis, black fever, animal bites, meningitis of all kinds, bird flu, swine flu). It was determined whether there are significant differences in the number of health institutions in terms of their distribution across all governorates of Iraq, or not. Also, is there a significant difference in the number of infections with communicable diseases in all governorates of Iraq or not? If there is a significant difference in the number of health institutions or the number of infections with communicable diseases, whichever number is higher. The study included the total number of health institutions in Iraq, as well as the total number of communicable diseases of various types in all governorates of Iraq. The results were obtained by applying the Friedman test, in addition to two-way analysis of variance, as well as the Scheffé test.

Характеристика перебігу епідемічного процесу скарлатини у сучасних умовах

S carlet fever is one of the most common nosological forms of group A streptococcal infection (SGA). In recent years, there has been an increase in the incidence of this infection in the countries of Europe and Asia, the USA and Canada. The analysis of professional publications of different countries of the world regarding the manifestations of the epidemic process of scarlet fever was carried out, as well as information on epidemiological studies conducted by the authors was provided. It has been established that children remain the leading risk group for scarlet fever, men are more often affected among adults, but the role of young women who care for children as a source of infection is increasing. The aerosol-aspiration mechanism of transmission of the causative agent of scarlet fever is realized by airborne and contact-household ways of its transmission. There is an intensification of the contact-household way of transmission of the pathogen. An atypical course of scarlet fever is observed with manifestations of co-infection, in particular, gastroenterocolitis, chicken pox and respiratory infections. A significant number of publications are devoted to the influence of environmental factors on the course of the epidemic process of scarlet fever. The authors note a direct correlation between the incidence of scarlet fever and atmospheric air pollutants, meteorological factors, as well as the influence of social and economic factors on the epidemic situation of this infection. Long-term use of antibiotics has contributed to the development of antibiotic resistance to the most common drugs, which prompts scientists to develop vaccines against iSGA. So, scarlet fever is characterized by widespread distribution, impression of mainly children, co-infection, atypical clinical course, especially in immunocompromised persons, and implementation of the contact-household way of transmission of the pathogen. The influence of social, natural and environmental factors on the course of the epidemic process of scarlet fever has been established, which is important to consider when conducting epidemiological surveillance of this infection. The introduction of vaccination against iSGA will contribute to the reduction of antibiotic resistance, which is currently a global problem for humanity. We consider it necessary to include scarlet fever and other iSGA in the list of infectious diseases subject to registration in Ukraine. Key words: scarlet fever, incidence, risk groups, ways of pathogen transmission, atypical course, co-infection, environmental factors, antibiotic resistance.

Mathematical modeling of chickenpox transmission using the Laplace Adomian Decomposition Method

In this work, mathematical modeling of a nonlinear differential equation was studied to investigate the effect of vaccination on the spread of chickenpox. The proof of existence and uniqueness of the positive solution and invariant region showed that the model is epidemiologically sound. We established the disease-free and endemic equilibrium states and carried out a stability analysis of the disease-free and endemic equilibrium states of the model to gain insight into the dynamics of the model. The rate of vaccination and precaution for the spread of chickenpox was a factor that influenced the basic reproductive number, which was calculated using the next-generation matrix approach. Forecasts made via numerical simulation using the Laplace Adomian Decomposition method highlight the temporal impact of vaccination on curbing the chicken pox trend.

Facts about Wildlife Diseases: Things You Should Know about Mule Deerpox Virus in Farmed White-Tailed Deer in Florida

Pox viruses are widespread and infect many hosts, including insects, reptiles, birds, and mammals. Some, like chicken pox, are highly adapted to humans, and others, like monkeypox, can be transmitted from species to species. All are highly contagious and usually cause lesions or rashes. Poxvirus infections occur in domestic hoofstock, including cattle, sheep, goats, camels, horses, and swine, and they have been reported in wild ungulates, including mountain sheep, mountain goats, reindeer, mule deer, musk-ox, caribou, moose, and white-tailed deer. In 1983, Mule deerpox virus, a genetically distinct pox virus, was found in free-ranging mule deer in Wyoming. Since the 1990s, several cases of mule deerpox virus have been reported from black-tailed deer from California and Oregon and a white-tailed deer from Mississippi, suggesting that this virus may be a potential emerging pathogen for white-tailed deer. It is unclear whether the virus is more prevalent or whether detection has increased.

Ethnomedicinal Plants and Herbal Preparations Used by Rural Communities in Tehsil Hajira (Poonch District of Azad Kashmir, Pakistan).

The present study emphasizes the importance of documenting ethnomedicinal plants and herbal practices of the local rural communities of Tehsil Hajira (Pakistan). The aim was to document, explore and quantify the traditional ethnomedicinal knowledge. Ethnobotanical data were collected using semi-structured questionnaires and analyzed using various quantitative indices. The results showed that 144 medicinal plant species from 70 families and 128 genera play an important role in herbal preparations. The most common type of preparation was powder (19.0%), followed by paste (16.7%), aqueous extract (15.7%), decoction (14.7%) and juice (11.0%). Fragaria nubicola (0.94) and Viola canescens (0.93) had the highest relative frequency of mention (RFC), while Berberis lycium (1.22) and Fragaria nubicola (1.18) had the highest use value (UV). Geranium wallichianum (85.5), Ligustrum lucidum (83) and Indigofera heterantha (71.5) were the most important species in the study area with the highest relative importance (RI) value. The diseases treated were categorized into 17 classes, with diseases of the digestive system and liver having the highest Informant Consensus Factor (ICF) value, followed by diseases of the oropharynx and musculoskeletal system. Important plants mentioned for the treatment of various diseases of the gastrointestinal tract are Zanthoxylum alatum, Berberis lycium, Mentha longifolia, Punica granatum, Rubus ellipticus and Viola canescens. New applications of rarely documented plants from this area are: Oxalis corniculata paste of the whole plant to treat vitiligo, Carthamus tinctorius flowers to treat chicken pox, Dioscorea deltoidea tuber powder to treat productive cough, Inula cappa root decoction to treat miscarriage, Habenaria digitata tuber juice for the treatment of fever, Viola canescens leaves and flowers for the treatment of sore throat and Achillea millefolium root and leaf juice for the treatment of pneumonia. These plants may contain interesting biochemical compounds and should be subjected to further pharmacological studies to develop new drugs. Traditional medicinal knowledge in the area under study is mainly limited to the elderly, traditional healers and midwives. Therefore, resource conservation strategies and future pharmacological studies are strongly recommended.

Descriptive Study of Chicken Pox in the Post Graduated Hospital Khost Afghanistan

Chicken pox is an acute infectious disease of viral etiology, characterized by the appearance of characteristic blistering rash against the background of a general intoxication syndrome. (13, 14) The causative agent of chickenpox is the herpes virus type 3, transmitted from a patient by airborne droplets. Chickenpox is one of the most common childhood infections. It is manifested by characteristic abundant itchy blistering rashes that appear at the height of fever and general infectious manifestations. (15, 16) A typical clinic allows you to diagnose the disease without conducting any additional research. Treatment of chickenpox is mainly symptomatic. To prevent secondary infection, antiseptic treatment of rash elements is recommended. Infants and Children are affects in all ages, but most severely infants, who experience the highest age-specific incidence and account for almost all Chickenpox hospitalizations and deaths. (17, 18, 19) Research Goal: Case of Chickenpox in the Khost post graduated hospital from the 1399/06/01 to 1399/12/30. Methodology: This is a descriptive study that was conducted in the form of a case series. This study was conducted on 43 patients affected by chicken pox.

Factors influencing the hesitancy and refusal of vaccines in India: A study-using tool developed by WHO SAGE Working Group

Objectives: This study aimed to assess the hesitancy towards vaccination and to identify the factors and predictor variables within the study population. Methodology: This was a cross-sectional study conducted via a web-based platform where a validated questionnaire was circulated among the public to understand their hesitancy towards vaccination. WHO SAGE Working Group Questionnaire was used to collect the data. The predictors for hesitancy were determined by using bivariate logistic regression analysis and the prevalence of vaccine hesitancy was identified. Results: A total of 353 subjects enrolled in the study during the 6 months of the study. Among them, 133 (37.67%) subjects showed vaccine hesitancy. On performing the bi-variate analysis, it was found that among the subsets studies those who were more hesitant to receive vaccines were females (OR: 1.476); individuals who are widowed/separated/divorced (OR: 3.109), age 40–49 yrs (OR: 3.710); from a rural (OR: 1.277) and not graduated (OR: 1.077). These subsets were predictors identified for vaccine hesitancy. Among the vaccines, maximum hesitancy was observed for the chicken pox vaccine [47 (13.31%)], followed by TCV [25 (7.08%)] and Rota [24 (6.79%), whereas the minimum hesitancy was observed for BCG [2 (0.56%)], OPV [4 (1.13%)] and IPV [8 (2.26%)]. Reasons provided for the hesitancy observed were mainly (i) Did not think it was needed [163 (46.17%)], (ii) Did not think the vaccine was safe [41 (11.61%)] and (iii) Did not know where to get vaccinated [24 (6.79%)]. Conclusion: The study observed less vaccine hesitancy among vaccines included in the EPI program. A major contributing factor for VH among the study population was their wrong perception about vaccines as that is not needed and not safe. Hence, there is a real need for education to the population to improve vaccine confidence among the general population.

Identifying the main determinants that have an impact on the level of vaccination among children

Background. Thanks to vaccinations, many infections, including whooping cough, diphtheria, tetanus, poliomyelitis, measles, mumps, rubella, hepatitis B, hemophilic infection, pneumococcal infection, meningococcal infection, rotavirus infection, chicken pox, hepatitis A, papillomavirus infection, etc., can be prevented. According to the WHO research, it was established that if the level of vaccination coverage of the country's population drops by several percents, it creates favorable conditions for the spread of infectious diseases, that the lower the collective immunity, the higher the probability of outbreaks and epidemics. The Aim. Тo study and analyze the impact of risk factors on reducing the level of vaccine prophylaxis in the childhood population. Materials and Methods. This study was conducted using the questionnaire method, for which a questionnaire was developed. Group 1 consisted of 280 children who received a vaccination and group 2 consisted of 180 children who were not vaccinated. The parents of these children were interviewed using the author's questionnaire and gave their consent to use the medical data of the children for scientific research. Non-parametric statistical analysis for two independent sample populations was used to compare median values Mann-Whitney test. Fisher's test was used to compare proportions. Results. During the study, it was found that the most frequent reasons for parents' refusal to vaccinate their children were: religious views of family members 2.4 times increase the risk of non-vaccination in children; in single-parent families where the parents are divorced, children did not receive any vaccination 2.6 times more than in full-parent families; unfinished average of 35.7 times and lack of education 24.1 times increase the impact on the lack of vaccination in children. Conclusions. We identified the following risk factors that influence the vaccination rate, namely: demographic, socio-economic, biological and socio-psychological. Keywords: vaccine prevention, statistics, infectious diseases, risk factors.

Clinical and molecular detection of fowl pox in domestic pigeons in Basrah Southern of Iraq

Bird species, particularly poultry and other bird types, including domestic pigeons, are susceptible to fowl pox, a contagious viral disease. The main goal of this study was to validate clinical avipoxvirus diagnoses using molecular analytical methods. The essential components of the investigation were the clinical signs, visible abnormalities, histological changes, and polymerase chain reaction analysis. Twenty out of 120 pigeons had clinical symptoms, which included yellowish crust or nodules near the feet, eyes, and beak. An erosive epidermal lesion and an epidermal acanthotic papular lesion with basal vacuolation were maculopapular evidence associated with significant epidermal hyperkeratosis, as confirmed by histological analysis. In addition, the results showed keratinocyte necrosis beneath the hyperkeratotic epidermal layer, together with superficial and deep dermal perivascular lymphocytic infiltration. In addition, the P4b core protein gene underwent phylogenetic analysis. The sequence analysis results indicated a high degree of similarity across the local strains, with just minor variations observed. Five sample sequences were selected and submitted to the NCBI database. These sequences were identified as OR187728, OR187729, OR187730, OR187731, and OR187732. All the various strains in this research may be classified under clade A of the chicken pox virus phylogenetic classification. This study presents the first description and characterization of pox virus infections in domestic pigeons inside the Basrah governorate.

A NEPHROPROTECTIVE EFFECT OF CARISSA SPINARUM AGAINST GENTAMICIN INDUCED OXIDATIVE NEPHROTOXICITY

One of the most prevalent issues with the kidneys is nephrotoxicity, which happens when the body is exposed to a toxin or medicine. With the growing availability of powerful therapeutic medications such as aminoglycoside antibiotics, chemotherapeutic agents, and nonsteroidal anti-inflammatory drugs (NSAIDs), a variety of pharmaceuticals can have a negative impact on the kidney, leading to acute renal failure, chronic interstitial nephritis, and nephritic syndrome. Ethiopian native Carissa spinarum (Apocynaceae) is traditionally used to treat skin conditions, rheumatism, diarrhoea, chicken pox, and stomachaches. The herbal plant Carissa spinarum possesses antioxidant qualities. The term "nephrotoxicity" describes the detrimental effects that different drugs can have on the kidneys, which can result in damage and dysfunction. This illness offers a serious risk to kidney health and can be brought on by exposure to specific medicines, chemicals, or poisons. Understanding the methods by which these substances affect the structure and function of the kidneys—such as oxidative stress, inflammation, and interference with essential cellular processes—is necessary to comprehend the abstract idea of nephrotoxicity. Nephrotoxicity management also involves establishing prevention and management strategies, identifying, and tracking possible nephrotoxic substances, and managing and preventing nephrotoxicity. All things considered, an abstract comprehension of nephrotoxicity entails investigating the complex pathways and circumstances that lead to renal injury and formulating strategies to lessen or offset these detrimental effects on kidney function.

Vaccine safety beliefs in the state of Alaska

ObjectivesIdentifying the key factors associated with vaccine hesitancy remains a challenge as has been highlighted throughout the COVID-19 vaccine roll out and pandemic. The aim of this study was to determine characteristics associated with vaccine safety and compare perceived safety by vaccine. Our hypothesis is that vaccine safety perception will vary by vaccine with COVID-19 as ranked lowest for safety. Study designCross sectional. MethodsA statewide sample (n = 1024) responded to an online 28-point questionnaire via anonymous linked invitation. ResultsAmong the eight vaccines assessed, COVID-19 had the lowest perceived safety (53.13%) followed by human papillomavirus HPV (63.38%). A binomial logistic regression assessed COVID-19 vaccine safety beliefs (safe v not safe) finding age, political orientation, and perceived safety of certain vaccines as statistically significant. As age increased by year, vaccine safety beliefs increased. Persons who identified as conservative demonstrated less belief in vaccine safety than all other groups. Among persons who did not perceive the COVID-19 vaccine as safe, 65.8% believed chicken pox was safe, 63.3% and 61.1% perceived hepatitis A& B were safe. ConclusionsThese findings demonstrate that vaccine safety beliefs differ by vaccine and that persons who do not believe in the safety of the COVID-19 are not exclusively against all vaccines. Understanding factors that increase vaccine safety by vaccine could assist in developing an intervention which could increase belief in safety for all vaccines.