Seabed liquefaction and sediment resuspension under wave loading are key issues in marine engineering, but are usually regarded as independent processes (instead of coexisting and interacting processes). Here, we analyzed random wave-induced seabed liquefaction and its impact on sediment resuspension using flume experiments. Results show that in a nonliquefaction scenario, excess pore pressure in the seabed oscillates with wave fluctuations, but pressure accumulation is low, while a consistent upward pressure gradient promotes sediment suspension. Wave-induced shear stress was the key driver of sediment resuspension in a nonliquefaction scenario. In the liquefied state, waves with different amplitudes differently responded to excess pore pressure; small-amplitude waves accumulated pressure, while large-amplitude waves dissipated it. Liquefied soil formed mud waves, creating elliptical motion along with random waves. Seabed liquefaction accelerated sediment resuspension in the following ways: reducing soil critical shear stress; forming seepage channels inside the seabed; forming mud waves, resulting in increased turbulent kinetic energy; dissipating excess pore pressure and releasing porewater, expelling fine-grained sediment from the liquefied soil. Our study reveals the variation in excess pore pressure in silty seabed under random waves and its effect on sediment resuspension, which is significant for understanding soil liquefaction and sediment movement of silt.