Variation In Incidence Rates Research Articles

Landscape‐scale patterns and predictors of potato viruses in Scotland

AbstractVirus diseases represent important economic threats to seed potato production worldwide, yet relatively little is known of their epidemiology at the landscape‐scale. In this study, data was compiled from the Scottish national seed potato classification scheme on the incidence of 10 different potato viruses for the years 2009–2022. A co‐occurrence analysis identified that 12 virus species pairs occurred together more often than expected by chance, and potato blackleg was positively associated with eight potato viruses. ArcGIS was used to investigate spatial and spatiotemporal variation in incidence rates of the three most prevalent viruses (potato virus Y, potato leaf roll virus and potato virus A), and this revealed prominent geographic differences in long‐term disease outcomes. Focusing on potato virus Y as the most commonly occurring single infection, interpretable machine‐learning techniques were used to investigate the influence of key crop, management and environmental factors on patterns of incidence in space and time. The results showed that health characteristics of seed stocks were among the most important predictors of incidence, along with blackleg infection, several management features, cultivar resistance, distance to the nearest seed and ware crop, temperature variables and several soil features. This approach provides a comprehensive overview of potato viruses in Scotland, a deeper understanding of epidemiological risk factors at the landscape‐scale and a forecast model that could serve as the basis of a decision support tool for improved management of potato virus Y.

Cryptic circulation of chikungunya virus in São Jose do Rio Preto, Brazil, 2015-2019.

Chikungunya virus (CHIKV) has spread across Brazil with varying incidence rates depending on the affected areas. Due to cocirculation of arboviruses and overlapping disease symptoms, CHIKV infection may be underdiagnosed. To understand the lack of CHIKV epidemics in São José do Rio Preto (SJdRP), São Paulo (SP), Brazil, we evaluated viral circulation by investigating anti-CHIKV IgG seroconversion in a prospective study of asymptomatic individuals and detecting anti-CHIKV IgM in individuals suspected of dengue infection, as well as CHIKV presence in Aedes mosquitoes. The opportunity to assess two different groups (symptomatic and asymptomatic) exposed at the same geographic region aimed to broaden the possibility of identifying the viral circulation, which had been previously considered absent. Based on a prospective population study model and demographic characteristics (sex and age), we analyzed the anti-CHIKV IgG seroconversion rate in 341 subjects by ELISA over four years. The seroprevalence increased from 0.35% in the first year to 2.3% after 3 years of follow-up. Additionally, we investigated 497 samples from a blood panel collected from dengue-suspected individuals during the 2019 dengue outbreak in SJdRP. In total, 4.4% were positive for anti-CHIKV IgM, and 8.6% were positive for IgG. To exclude alphavirus cross-reactivity, we evaluated the presence of anti-Mayaro virus (MAYV) IgG by ELISA, and the positivity rate was 0.3% in the population study and 0.8% in the blood panel samples. In CHIKV and MAYV plaque reduction neutralization tests (PRNTs), the positivity rate for CHIKV-neutralizing antibodies in these ELISA-positive samples was 46.7%, while no MAYV-neutralizing antibodies were detected. Genomic sequencing and phylogenetic analysis revealed CHIKV genotype ECSA in São José do Rio Preto, SP. Finally, mosquitoes collected to complement human surveillance revealed CHIKV positivity of 2.76% of A. aegypti and 9.09% of A. albopictus (although it was far less abundant than A. aegypti) by RT-qPCR. Our data suggest cryptic CHIKV circulation in SJdRP detected by continual active surveillance. These low levels, but increasing, of viral circulation highlight the possibility of CHIKV outbreaks, as there is a large naïve population. Improved knowledge of the epidemiological situation might aid in outbreaks prevention.

Pengaruh Akupresure Pada Titik Perikardium 6 Terhadap Intensitas Mual Muntah Pada Ibu Hamil Trimester I di TPMB I Tahun 2023

Nausea and vomiting in pregnancy occur as a result of changes in the endocrine system that occur during pregnancy. According to WHO, pregnancies with excessive nausea and vomiting reach 12.5% of all pregnancies in the world with varying incidence rates. In Bekasi Regency in 2018 there were 206 pregnant women with nausea and vomiting in the first trimester. Therapy to reduce nausea and vomiting can be done by means of acupressure at pericardium point 6 3 times a day with a minimum duration of 10 minutes. The aim of this study was to determine the effect of acupressure at pericardium point 6 on the intensity of nausea and vomiting in pregnant women at TPMB I in 2023.The research method used is the Pre-experimental One Group With Pre-Post Test Design method. Sampling was taken with a total sampling of 30 people. Data analysis used frequency distribution and Wilcoxon test. This research uses primary data from observation values by researchers.The results of the study showed that all respondents experienced a decrease in nausea and vomiting after acupressure was carried out at point P6. The P value is 0.000 < 0.05 so it can be concluded that Ha is accepted or Ho is rejected, meaning there is a significant influence on administering acupressure at point P6 to pregnant women with nausea and vomiting at TPMB I in 2023.It is hoped that this research can be used as an alternative non-pharmacological technique that is easy to carry out without harmful effects in providing intervention for cases of nausea and vomiting in pregnant women.

To study the utility of HER2 and Ki-67 as immunohistochemical prognostic markers in comparison to histopathological parameters and tumour, node and metastasis staging in colorectal carcinoma.

Colorectal Carcinoma (CRC) ranks among the most prevalent cancers globally, with significant variability in incidence rates across different regions. A shift towards a Westernized diet has been implicated in rising cancer rates, particularly in emerging nations. By 2020, CRC is projected to represent a notable proportion of global cancer cases and deaths. In India, CRC primarily affects individuals aged 45 to 84, with a higher incidence in males, commonly occurring in the rectum and sigmoid colon. Risk factors such as obesity, dietary factors, sedentary lifestyle, smoking, and alcohol use contribute to CRC development, especially in aging populations. Diagnosis involves various imaging modalities and histological assessments using Tumour, node and metastasis (TNM) and American Joint Committee on Cancer classifications. Recent advancements in targeted therapies like monoclonal antibodies against HER2 have shown promise in treating metastatic CRC. Immunohistochemistry markers like Ki-67 and HER2 play crucial roles in prognostic assessment and treatment planning. This study aims to investigate Ki-67 and HER2 expression in CRC, correlating with histological characteristics and prognostic factors.

Eosinophilic esophagitis in adults and adolescents: epidemiology, diagnostic challenges, and management strategies for a type 2 inflammatory disease.

Eosinophilic esophagitis (EoE) is recognized as a chronic type 2 inflammatory disease characterized by the eosinophilic infiltration of the esophageal tissue, posing a significant disease burden and highlighting the necessity for novel management strategies to address unmet clinical needs. To critically evaluate the existing literature on the epidemiology and management of EoE, identify evidence gaps, and assess the efficacy of current and emerging treatment modalities. An extensive literature review was conducted, focusing on the epidemiological trends, diagnostic challenges, and therapeutic interventions for EoE. This was complemented by a survey among physicians and consultations with a scientific expert panel, including a patient's association (ESEO Italia), to enrich the study findings. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, scrutinizing epidemiological studies and management research to compile comprehensive insights into the disease's landscape. The physician survey and expert panel discussions aimed to bridge identified evidence gaps. The review included 59 epidemiological and 51 management studies, uncovering variable incidence and prevalence rates of EoE globally, with an estimated diagnosed prevalence of 41 per 100,000 in Italy. Diagnostic challenges were identified, including nonspecific symptoms and the lack of definitive biomarkers, which complicate the use of endoscopy. Treatment options such as elimination diets, proton-pump inhibitors, and swallowed corticosteroids were found to have varying success rates, while Dupilumab, an emerging therapy targeting interleukin (IL)-4 and IL-13, shows promise. Despite advancements in understanding and managing EoE, significant unmet clinical needs remain, particularly in biomarker identification, therapy personalization, and cost-effectiveness evaluation. A comprehensive, multidimensional approach to patient management is required, emphasizing the importance of early symptom recognition, accurate diagnosis, and tailored treatment strategies. Dupilumab offers potential as a novel treatment, underscoring the need for future research to explore the economic and social dimensions of EoE care pathways.

Incidence and Molecular Characterization of Citrus Bacterial Canker Disease in Pakistan

The prevalence of Citrus Bacterial Canker (CBC) in the Indo-Pak subcontinent, particularly in Pakistan, poses a significant economic threat due to its quarantine implications. This research aimed to assess the current status of CBC in major citrus-growing regions of Punjab and KPK, shedding light on the incidence and severity of the disease. In Punjab, varying degrees of CBC incidence (20-81 %) were observed across different districts, with Sargodha, Toba Tek Singh, Faisalabad, Chiniot, and Mianwali showing higher rates. Conversely, Sialkot and Sahiwal were found to be free from the disease. The severity of CBC was most pronounced in Mianwali (26.2 %), highlighting the region's vulnerability. Similarly, in KPK, varying incidence rates (3-7 %) were recorded, with Haripur, Nowshera, Lower Dir, and Swat reporting minimal or no occurrences. A total number of ninety-six were confirmed as Xanthomonas citri pv. citri through PCR and pathogenicity tests. Despite these findings, further research is imperative to unravel the pathogenic diversity of X. citri in Pakistan, paving the way for more targeted and effective management strategies. This research underscores the importance of ongoing monitoring and in-depth investigations to mitigate the economic impact of CBC on the citrus industry in Pakistan. Identifying and understanding the pathogenic variations within X. citri will be crucial for devising sustainable and region-specific control measures.

Incidence and prevalence of myasthenia gravis in the United States: A claims-based analysis.

Myasthenia gravis (MG) is a rare neuromuscular disorder with geographically variable prevalence and incidence rates. A global trend of increasing prevalence of MG has been observed in the last few decades, and this study aimed to assess the current prevalence and incidence rates of MG in the United States. Data were extracted from the Clarivate Real-World Data Repository (2016-2021), a US claims and electronic health records database. The prevalence and incidence of MG were calculated for the year 2021 for males and females who were <2, 2-5, 6-11, 12-17, 18-49, 50-64, and ≥65 years of age, using population estimates from the US Census. The diagnosed prevalence and incidence of MG in the United States in 2021 were calculated to be 37.0 per 100,000 persons and 3.1 per 100,000 persons, respectively. While the incidence and prevalence of MG increased with age in both men and women, higher prevalence and incidence of MG were observed in younger women (<50 years) compared with men of matching age, and in older men (≥65 years) compared with women of the same age group. The updated prevalence and incidence of MG in the United States in 2021 are higher than previous reports from the 1980s and early 2000s, following a global trend of increased prevalence and incidence for this disorder in the last few decades.

Giant Cell Tumor: Pathogenesis and Clinical Manifestation

A giant cell tumor of bone (GCTB) as known as a benign bone tumor (neoplasm) is aggressive locally and frequently recurs, and it is characterized by the growth of mononuclear stromal cells and datia cells that resemble osteoclasts. GCTB has varying incidence rates and has been shown to have high mortality. GCTB patients have several treatment options, but the majority of patients still experience recurrence and even metastasis to other organs. This literature review aims to explain more deeply about Giant Cell Tumor (GCT) starting from the definition, etiology, epidemiology, pathogenesis, clinical manifestations and treatment options so that patients get a better prognosis. This literature review was conducted using the keywords "Giant Cell Tumor AND pathogenesis AND clinical manifestation" from PubMed dan Google Scholar. The results of the literature review carried out are that the molecular and biological pathogenesis of GCTB consists of 4 processes, namely tumorigenesis of neoplastic mononuclear stromal cells, generation of reactive multinucleated giant cells, bone resorption/migration, and bone matrix remodeling for angiogenesis, invasiveness, and metastasis. Besides, the histological picture of GCTB contains "reactive" osteoclasts such as multinucleated giant cells (Giant Cells/GC), round cells such as macrophages and spindle stromal cells such as "neoplastic" fibroblasts (mononuclear stromal cells/SC) which are important findings in establishing the diagnosis. In conclusion, staging and management are very important to produce a better prognosis and reduce recurrence rates in GCTB patients.

Trends and prediction in the incidence rate of hepatitis C in Shandong Province in China from 2004 to 2030

BackgroundHepatitis C threatens human health and brings a heavy economic burden. Shandong Province is the second most populous province in China and has uneven regional economic development. Therefore, we analyzed the incidence rate trend and regional differences of hepatitis C in Shandong Province from 2004 to 2021. MethodsThe monthly and annual incidence rates of hepatitis C in Shandong Province from 2022 to 2030 were predicted by fitting Autoregressive Integrated Moving Average model (ARIMA), Long Short-Term Memory (LSTM) and ARIMA-LSTM combined model. ResultsFrom 2004 to 2021, annual new cases of hepatitis C in Shandong Province increased from 635 to 5834, with a total of 61,707 cases. The incidence rate increased from 0.69/100 thousand in 2004 to 6.40/100 thousand in 2019, with a slight decrease in 2020 and 2021. The average annual incidence rate was 3.47/100 thousand. In terms of regional distribution, the hepatitis C incidence rate in Shandong Province was generally high in the west and low in the east. It is estimated that the hepatitis C incidence rate in Shandong Province will be 9.21 per 100 thousand in 2030. ConclusionThe hepatitis C incidence rate in Shandong Province showed an increasing trend from 2004 to 2019 and a decreasing trend in 2020 and 2021. Significant regional variations in incidence rate existed. An upward trend in incidence rate is predicted from 2022 to 2030. It is necessary to strengthen the prevention and control of hepatitis C to achieve the goal of eliminating viral hepatitis by 2030.

Associations between Serum CRP Concentration, Maternal Hypertension, and Fetal Outcome: A Comparative Analysis in Pregnant Women

Introduction: Pre-eclampsia is a complex disorder characterized by hypertension and proteinuria after 20 weeks of gestation, posing risks to maternal and fetal health. It is linked to adverse outcomes worldwide, with varying incidence rates across regions. Risk factors include history, maternal age, and socioeconomics. The pathophysiology involves issues with spiral artery adaptation. The study aimed to analyze the associations between serum CRP concentration, maternal hypertension, and fetal outcomes in pregnant women. Methods: This cross- sectional analytical study was conducted at the Department of Obstetrics and Gynecology at the Institute of Child and Mother Health (ICMH), Matuail, Dhaka. It took place from January to December 2018. The study population comprised 120 pregnant women within the gestational age of 28-40 weeks. The women were categorized into three groups: Group A (control) consisted of normotensive pregnant women, Group B included pregnant women with mild pre-eclampsia, and Group C comprised pregnant women with severe pre-eclampsia. Ethical guidelines were followed, including IRB approval and participant consent. Data were analyzed using SPSS software, version, 22.0. Chi-Square, t-test, and ANOVA test were performed to determine associations among the study variables of the groups, where p&lt;0.05 considered as the level of significance. Results: The study enrolled 120 participants divided into Groups A, B, and C. The majority fell within the 18-25 age range. The mean ages were 24.23±4.52 (Group A), 24.73±4.01 (Group B), and 24.26±3.07 (Group C). BMI was significantly higher in Groups A and B compared to Group C (p &lt; 0.05). Gestational age was lower in mild and severe preeclampsia compared to normal pregnancies (p &lt; 0.05). Cesarean section delivery was significantly more frequent in preeclamptic mothers (p &lt; 0.001). CRP levels varied, with means of 3.07 (Group A), 9.67 (Group B), and 13.15 (Group C), showing significant differences (p &lt; 0.05). Fetal birth weight was lowest in Group C (2.61) and highest in Group A (2.95). Severe preeclampsia patients had elevated CRP levels, with 93.3% exhibiting this trend (p &lt; 0.05). Adverse neonatal outcomes were more common in preeclampsia cases, including prematurity, LBW, and neonatal complications (p &lt; 0.05). Increased CRP levels were associated with low birth weight (p &lt; 0.001) and lower APGAR scores (p &lt; 0.01). Conclusion: Pre- eclampsia shows raised serum CRP levels, particularly pronounced in severe cases, with about 83% of patients affected. This heightened CRP connects to adverse fetal outcomes.

Geoepidemiological perspective on COVID-19 pandemic review, an insight into the global impact.

The COVID-19 pandemic showed major impacts, on societies worldwide, challenging healthcare systems, economies, and daily life of people. Geoepidemiology, an emerging field that combines geography and epidemiology, has played a vital role in understanding and combatting the spread of the virus. This interdisciplinary approach has provided insights into the spatial patterns, risk factors, and transmission dynamics of the COVID-19 pandemic at different scales, from local communities to global populations. Spatial patterns have revealed variations in incidence rates, with urban-rural divides and regional hotspots playing significant roles. Cross-border transmission has highlighted the importance of travel restrictions and coordinated public health responses. Risk factors such as age, underlying health conditions, socioeconomic factors, occupation, demographics, and behavior have influenced vulnerability and outcomes. Geoepidemiology has also provided insights into the transmissibility and spread of COVID-19, emphasizing the importance of asymptomatic and pre-symptomatic transmission, super-spreading events, and the impact of variants. Geoepidemiology should be vital in understanding and responding to evolving new viral challenges of this and future pandemics.

Human papillomavirus-associated anal squamous cell carcinoma: sociodemographic, geographic, and county-level economic trends in incidence rates-United States, 2001-2019.

Incidence of anal squamous cell carcinoma is increasing, but vaccination against human papillomavirus (HPV) and removal of precancerous anal lesions could prevent new cases. The overall HPV-associated cancer incidence is reported to be higher in rural populations and in counties with lower economic status. We assessed these differences specifically for HPV-associated anal squamous cell carcinoma and described the geographic, county-level economic, and sociodemographic variations in incidence rates and trends. We analyzed data from the US Cancer Statistics to assess age-standardized incidence rates of HPV-associated squamous cell carcinomas among adults aged 18 years and older from 2001 to 2019. We calculated rate ratios and 95% confidence intervals to examine differences in incidence rates. We also quantified changes in incidence rates over time using joinpoint regression. From 2001 to 2019, 72 421 new cases of HPV-associated anal squamous cell carcinoma were diagnosed among women (2.8 per 100 000) and 37 147 among men (1.7 per 100 000). Age-standardized incidence rates were higher in the South compared with other census regions and in counties ranked in the bottom 25% and 25%-75% economically than in the top 25%. The overall incidence rate increased in women but remained stable in men during 2009-2019. Incidence rates increased in adults aged 50 years and older but decreased among those aged 40-44 years from 2001 to 2019 in women and from 2007 to 2019 in men. There were inequities in HPV-associated anal squamous cell carcinoma incidence by geographic and county-level economic characteristics. Failure to improve vaccine and treatment equity may widen existing disparities.

Public awareness and attitude toward premarital screening program in Jazan region, Saudi Arabia, an endemic area for hemoglobinopathies: A cross-sectional study.

Hemoglobinopathies are highly prevalent in Saudi Arabia, with varying incidence rates across different regions. The Eastern and Jazan regions have the highest incidence rates. To prevent hemoglobinopathies, the premarital screening program (PMS) has been established in Saudi Arabia to identify at-risk couples before marriage. This cross-sectional descriptive study aimed to evaluate the awareness and attitude of young adults towards PMS in Jazan, Saudi Arabia, which involved 875 individuals (560 men and 315 women). The current study report significant association between sex, personal and family history of disease, and attitude towards PMS among young adults (P< 0.05). The study concludes that while there is a substantial level of awareness and positive attitude towards PMS among the population, there is a need for more detailed health campaigns led by healthcare providers, rulers, and Islamic leaders to highlight the importance of PMS as a preventative measure to reduce the incidence of hemoglobinopathies in Jazan, Saudi Arabia.

Prevalence of sleep disturbances and associated factors among Chinese residents: A web-based empirical survey of 2019.

To identify the prevalence of sleep disorders in China through a large sample study. To explore the relevant social determinants affecting residents' sleep status at both individual and provincial levels based on the theoretical framework of the Dahlgren-Whitehead model. A nationwide cross-sectional web-based survey was conducted from January 20 to February 28, 2019 across 31 provinces of China. The Pittsburgh Sleep Quality Index was used to evaluate residents' sleep quality. Multilevel linear regression analysis was used to analyse the influencing factors of sleep disorder. A sample of 107 650 residents completed the survey, and 94 454 questionnaires were included in the final analysis. The crude incidence rate and the age-adjusted rate of sleep disorder in Chinese residents were 19.16% and 21.25%, respectively. Those who were older, female, smokers, drinkers, married, divorced, or widowed, retired, more educated (regression coefficient (b) = 0.172, P < 0.05), had worse self-perceived economic status, and lived far away from community health services (b = 0.758, P < 0.05) were more likely to have sleep problems. Physical exercise, social support (b = -1.705, P < 0.05), and greening coverage of residential areas (b = -1.769, P < 0.05) were protective factors for residents' sleep quality. Sleep disorders are prevalent in the Chinese population, with varying incidence rates across provinces. To improve sleep quality, the Chinese government and health management departments should pay more attention to vulnerable groups and promote healthy lifestyles through education. Additionally, the social network can be utilized to provide social support. Improving the ecological environment and daily living environment is also essential.

Racial and ethnic differences in thymic epithelial tumors: A single-institution retrospective analysis.

e20649 Background: Thymic epithelial tumors (TETs) are a rare, heterogeneous group of malignancies that arise from the thymus. While the etiology of TETs remains unknown, variation in incidence rates amongst racial/ethnic groups has raised the possibility of germline predispositions. Unfortunately, due to the rarity of this disease, there is a limited understanding of the impact of race/ethnicity on tumor characteristics and treatment outcomes for TET patients. We sought to characterize patient/tumor data and investigate treatment outcomes based on race and ethnicity. Methods: We conducted a single-institution, retrospective database analysis of TET patients evaluated at the IUSCCC from 1979 – 2021 from which clinical annotations were available for 477 thymoma and 164 thymic carcinoma (TC) patients. We identified 112 thymoma and 35 TC patients who were deemed to have sufficient data for evaluation of racial/ethnic characteristics. Demographic/clinical variables and therapeutic interventions, including treatment outcomes, were analyzed. Data was compiled and analyzed using descriptive statistics and the Kaplan Meier method for survival analysis via GraphPad Prism software. Results: Of the 112 thymoma patients, 29 thymoma patients presented with de novo metastatic disease at the time of diagnosis. The median age at the time of diagnosis of all patients revealed a statistically significant difference between White and Black TET patients (53.0 v. 42.0 years, *p = 0.0195). There was a trend towards significance when median age of diagnosis between White and Asian TET patients was compared (53.0 v. 48.0 years, p = 0.0633, NS). Advanced histologic subtypes, include B3 and TC, appeared predominantly in Asian and Black patients at 77.7% and 56.3%, respectively, compared to White patients (44.9%), though the finding was not statistically significant. No statistically significant differences between racial/ethnic groups regarding progression free survival for unresectable or metastatic disease were observed, regardless of histology. There was a non-significant difference in recurrence free survival for resectable thymoma in White (30.0 months) and Asian/Pacific Islander (47.0 months) patients compared to Black patients (24.0 months). Conclusions: Overall, this analysis suggests differences in the median age of diagnosis for patients with thymic malignancies based on race, raising the possibility of inherent biologic differences driving oncogenesis and symptoms at the time of presentation. While no statistically significant differences in treatment outcomes were found based on race and ethnicity, Black patients appeared to experience shorter times to recurrence after definitive surgery. Further studies to understand the mechanistic differences driving tumorigenesis and potential disparities in treatment outcomes are greatly needed in this rare tumor type.

OVERVIEW OF MEDICATION ERROR INCIDENCE IN HOSPITALS IN VARIOUS COUNTRIES: LITERATURE REVIEW

Background: Medication error is one of the most common types of errors contributing to patient safety incidents in hospitals. In addition to their numerous cases and high costs, medication errors also contribute to deaths in various countries. Aims: This study describes the incidence of medication errors in hospitals in various countries, determines the phase of errors that occurred the most, and describes preventive strategies for medication errors in hospitals. Methods: This study was conducted between April 2021-July 2021 using the literature review method. Data were retrieved from ProQuest, ScienceDirect, PubMed, Google Scholar, and Garuda RistekBRIN. The data are generalized and extracted in a table based on the incidence of medication errors and preventive strategies. Results: Of the eleven included studies, the incidence of medication errors in one study conducted in Nigeria was the highest (80%). Four of the eleven studies were conducted in India with varying incidence rates. Most errors occurred during the prescribing stage. The number of reports and the number of events actually have no relevance. It can be said that countries with a high number of reporting have good reporting indicators. Strategies for preventing medication errors include the implementation of an information system in the CPOE (Computerized Physician Order Entry) form and providing training for staff. Conclusion: The difference in the incidence of medication errors in developing and developed economies can be attributed to factors in the healthcare system and the lower prescribing ratio and nurse ratio in developing countries. Keywords: literature review, medication errors, patient safety

OVERVIEW OF MEDICATION ERROR INCIDENCE IN HOSPITALS IN VARIOUS COUNTRIES: LITERATURE REVIEW

Background: Medication error is one of the most common types of errors contributing to patient safety incidents in hospitals. In addition to their numerous cases and high costs, medication errors also contribute to deaths in various countries. Aims: This study describes the incidence of medication errors in hospitals in various countries, determines the phase of errors that occurred the most, and describes preventive strategies for medication errors in hospitals. Methods: This study was conducted between April 2021-July 2021 using the literature review method. Data were retrieved from ProQuest, ScienceDirect, PubMed, Google Scholar, and Garuda RistekBRIN. The data are generalized and extracted in a table based on the incidence of medication errors and preventive strategies. Results: Of the eleven included studies, the incidence of medication errors in one study conducted in Nigeria was the highest (80%). Four of the eleven studies were conducted in India with varying incidence rates. Most errors occurred during the prescribing stage. The number of reports and the number of events actually have no relevance. It can be said that countries with a high number of reporting have good reporting indicators. Strategies for preventing medication errors include the implementation of an information system in the CPOE (Computerized Physician Order Entry) form and providing training for staff. Conclusion: The difference in the incidence of medication errors in developing and developed economies can be attributed to factors in the healthcare system and the lower prescribing ratio and nurse ratio in developing countries. Keywords: literature review, medication errors, patient safety

Regional features of the incidence of chronic Ph-negative myeloproliferative neoplasms in Belarus

According to published data, there are differences in the registered incidence of chronic Ph-negative myeloproliferative neoplasms (MPN) in some regions of the world. In this study, for the first time, we compare the Ph- MPN incidence in the regions of Belarus in order to determine the regional features.It was shown that for the period 2014-2018 the highest rates of standardized incidence of polycythemia vera were noted in the Brest region – 1,17 and Minsk – 1,11, the lowest incidence rate was determined in the Vitebsk region – 0,68 per 100,000 population per year, p&lt;0,05. The maximum incidence rates of essential thrombocythemia were recorded in Minsk city – 1,04 and Gomel region – 0,86, which is significantly higher than in Minsk region – 0,27, Vitebsk region – 0,35 and Grodno region – 0,44 per 100 000 population per year. The highest incidence rates of primary myelofibrosis were noted in Gomel – 0,63 and Vitebsk regions – 0,53, they were significantly higher than in Grodno – 0,14 and Minsk regions – 0,24 per 100 000 population per year.Differences in the incidence of Ph-MPN between the regions of Belarus were revealed, while the overall incidence rates in Minsk city, Gomel, Brest and Mogilev regions exceeded those in Vitebsk, Grodno and Minsk regions. In addition, variation in incidence rates for individual nosologies was noted. The information obtained can be used to make management decisions when organizing medical observation and treatment of patients with Ph- MPN in Belarus.

Impact of social and economic factors on global thyroid cancer incidence and mortality.

The incidence of thyroid cancer has increased substantially over the past few decades and is partially explained by overdiagnosis. Geographical variations in incidence rates were reported to be related to national development status. This study aimed to gain deeper insights into global thyroid cancer burden by incorporating additional social and economic factors to account for cross-national disparities. We performed a multivariate analysis of age-standardized incidence and mortality data from the GLOBOCAN 2020 database for 126 countries that had more than 100 incident cases of thyroid cancer. The human development index (HDI), current health expenditure, and additional Global Health Observatory indicators were extracted from multiple sources. Age-standardized incidence was highly correlated with HDI (standardized coefficient beta = 0.523, 95% confidence interval [CI] = 0.275-0.771) among the countries studied. The prevalence of raised fasting blood glucose was associated with age-standardized mortality (beta = 0.277, 95% CI = 0.038-0.517). Generally, the mortality-to-incidence ratio was higher in males than in females. In multivariate analysis, HDI (beta = - 0.767, 95% CI = - 0.902 to - 0.633), current health expenditure (beta = 0.265, 95% CI = 0.137-0.394), and fine particulate matter (PM2.5) concentrations (beta = 0.192, 95% CI = 0.086-0.298) were associated with mortality-to-incidence ratios. National developments gauged by HDI explain the majority of the variation in incidence rates of thyroid cancer but play a smaller role in disparities in mortality rates. The association between air pollution and thyroid cancer outcomes warrants further investigation.

Seasonality of main childhood embryonal tumours and rhabdomyosarcoma, France, 2000-2015.

Few studies have investigated the seasonal patterns of embryonal tumours. Based on data from the French National Registry of Childhood Cancers, the present study aimed to investigate seasonal variations in embryonal tumour incidence rates by month of birth and by month of diagnosis. The study included 6635 primary embryonal tumour cases diagnosed before the age of 15 years over the period 2000-2015 in mainland France. Assuming monthly variations in incidence rates were homogeneous over 2000-2015, we used a Poisson regression model to test for overall heterogeneity in standardised incidence ratios (SIRs) by month of birth or diagnosis. The seasonal scan statistic method was used to detect monthly excesses or deficits of embryonal tumour cases over the whole study period. The annual reproducibility of the observed monthly variations was formally tested. An overall heterogeneity in incidence rates by month of birth was observed for rhabdomyosarcoma in boys only. Based on the month of diagnosis, a seasonality was evidenced for unilateral retinoblastoma, with a lower incidence rate in the summer (SIRJul-Aug =0.68, 95% CI=0.52-0.87), whilst the incidence rate of rhabdomyosarcoma tended to be lower in August (SIRAug =0.68, 95% CI=0.52-0.89). No seasonality was detected for the other embryonal tumour groups by month of birth or month of diagnosis. This study is one of the largest to have investigated the seasonality of childhood embryonal tumours. The study showed a seasonal variation in the incidence rates by month of diagnosis for unilateral retinoblastoma and rhabdomyosarcoma. Our findings are likely to reflect a delay in consultation during the summer months. However, the role of seasonally varying environmental exposures cannot be ruled out.