BackgroundArrhythmia is a potentially fatal side effect of antipsychotics. A biologic predictive tool to prevent it is missing.AimIdentification of a genetic profile at risk for antipsychotic induced arrhythmia.ObjectiveIdentifying a molecular pathway enriched for antipsychotic induced QT-modifications.MethodsSeven hundred and sixty-five SKZ individuals, M = 556, age = 40.93 ± 11.03 were included. QT-variation was a phase-specific created variable. A nested mixed regression served in R for clinical and molecular pathway analyses. Plink served for genetic analyses. Quality checking was standard, inflation factor was controlled by lambda values.ResultsQuetiapine and Perphenazine were associated with QT variation (P = 0.002; Estimate = 5.79 and P = 5.67e-06; Estimate = 8.96 respectively). No other significant association was detected. No inflation was detected. Axon guidance and Collagen biosynthesis (Table 1) were associated with QT variation at a conservative (adjusted) P value < 0.01.ConclusionsTwo molecular pathways were identified as possibly involved in QT modifications during antispsychotic treatment in SKZ patients. Previous evidence supports a role of the same pathways in cardiac disorders [1,2]. Interaction of specific SNPs with the drugs will be focus of further research.Disclosure of interestThe authors have not supplied their declaration of competing interest.