Rapid economic development has changed land use and population density, which in turn affects the stability and carbon sequestration capacity of regional ecosystems. Net primary productivity (NPP) can reflect the carbon sequestration capacity of ecosystems and is affected by both climate change and human activities. Therefore, quantifying the relative contributions of climate change and human activities on NPP can help us understand the impact of climate change and human activities on the carbon sequestration capacity of ecosystems. At present, researchers have paid more attention to the impact of climate change and land use change on NPP. However, few studies have analyzed the response of the NPP to gross domestic product (GDP) and population density variations on a pixel scale. Therefore, this paper analyzes the impact of climate change and human activities to NPP on a pixel scale in the Nanjing metropolitan area. During the period 2000-2019, the annual mean NPP was 494.89 g C·m-2·year-1, and the NPP in the south of the Nanjing metropolitan area was higher than that in the north. The NPP was higher in the forest, followed by unused land, grassland, and cropland. In the past 20 years, the annual mean NPP showed a significant upward trend, with a growth rate of 3.78 g C·m-2·year-1. The increase in temperature and precipitation has led to an increasing trend of regional NPP, and the impact of precipitation on NPP was more significant than that of temperature. The transformation of land use from low-NPP type to high-NPP type also led to an increase in NPP. Land use change from high-NPP type to low-NPP type was the main cause of regional NPP decline. Residual analysis was used to analyze the impact of human activities on NPP. Over the last 20 years, the NPP affected by human activities (NPPhum) showed a high spatial pattern in the south and a low spatial pattern in the north, and the annual mean NPPhum also showed a fluctuating upward trend, with a growth rate of 2.00 g C·m-2·year-1. The NPPhum was influenced by both GDP and population density, and the impact of population density on NPP was greater than that of GDP.
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