In conjunction with Earth’s ongoing global warming, the Southwest China (SWC) region has become a fascinating case study on the control of local climate change. Moreover, an entire period of climate change may partially mask the patterns in some stages. Therefore, in this research, we investigated the spatial patterns of the significant turning years of climatic factor change, and determined the heterogeneity of the spatial patterns of climate change before and after the significant turning years. We used the long time-series of the CRU datasets (CRU_TS4.02) from 1901 to 2017 with a piecewise linear regression model to explore the significant turning-year distribution characteristics of inter-annual and inter-seasonal climate factor changes, and further describe and quantize the differences in the spatio-temporal patterns of climate factors before and after the significant turning years on the grid scale in SWC. Overall, the trends in temperature and precipitation factors in SWC were segmented over the last 120 years, with significant turning years with different regional and stepwise characteristics. In terms of timing, temperature and precipitation factors changed significantly in 1954 and 1928, respectively, and overall temporal variability (0.04 °C/(10 a) (p < 0.05), −0.48 mm/(10 a)) masked the magnitude or direction of variability (0.13 °C/(10 a) and 0.16 °C/(10 a) both at the level of p < 0.05 before the turning year, 19.56 mm/(10 a) (p < 0.05) and 1.19 mm/(10 a) after the turning year) around the watershed years. Spatially, the significant turning years were concentrated in the periods 1940–1993 (temperature) and 1910–2008 (precipitation), and the distribution pattern of the turning years was patchy and concentrated. The turning years of temperature factors were gradually delayed from east to west, and the variability of climate factors before and after the turning years exhibited significant shifts in location (e.g., temperature decreased from southeast to northwest before the turning year and increased after the turning year). After the turning year, the warming variability of the temperature factor increased, while the increasing variability of the precipitation factor decreased. Further integrated analysis revealed that the increase in variability of the climate factor after the turning year was mainly due to the increase in winter and autumn variability (0.05 °C/(10 a), 7.30 mm/(10 a) in autumn; and 0.12 °C/(10 a), 1.97 mm/(10 a) in winter). To the extent that this study provides a necessary academic foundation for efficiently unveiling the spatio-temporal variability properties of climate factors against the background of modern global climate change, more attention should be paid to the location and phase of the study.