The modernization of the manufacturing industry requires the development of the manufacturing process and technological equipment, in general, but also for the realization of the complex parts. These components with complex geometries and multiple functional roles, for the most part, are safety parts manufactured from materials with superior physicochemical characteristics that have demanding technical quotas and conditions, leading to difficulties in establishing the processing methods and technological equipment used. For those considerations, it is proposed a three-stage design-optimization algorithm and an additional step, which represents a balanced and rational approach to technological process issues and in the manufacturing system. The first stage shall determine the optimal number and succession of operations based on a technological graph and the associated mathematical model, in which the objective function and the restrictions are defined concerning the purpose pursued. The second stage establishes, for each technological operation, the optimal orientation and fixation scheme (O-OFS) of the semi-finished part, which ensures the precision of machining and the technological process productivity, applying elements, of the sets theory and the global utility method to the method of optimizing of orientation and fixation of the parts. In the third step, based on the optimal orientation and fixation scheme, a mathematical model is formulated for the adapted technology chart to describe the construction variants of the orientation supports, and to provide the optimal device construction solution to the analysed operation. In situations where a reconfiguration of the technological system is desired, the fourth step of equipment optimization of the entire technological process is proposed.