The International Labour Organisation (ILO) enforces health, safety, and welfare policies to ensure workers’ safety in the workplace, by preventing work-related injuries, diseases, incidents and deaths. This study investigated the implementation of the international labour organization policy on health, safety and welfare of workers in Central Senatorial District, of Delta State, as perceived by management staff and non-management staff. The survey research method was used. The Taro-Yamane sample size was used to select 201 management staff and 330 non-management staff from the ten selected oil and gas companies in Central Senatorial District, Delta State. The instrument used for data collection was a self-developed and validated questionnaire with reliability level of 0.97. Of the 531 copies of questionnaire administered to the respondents, 512 were correctly completed and used for analysis. Data obtained were analyzed using descriptive statistics (frequency counts, percentages, mean, standard deviation, Pearson correlation); post-estimation statistics (variance inflation factor) and inferential statistics (simple regression). ). The simple regression results indicated that while ILO policies and preventive measures are not significantly available in the oil and gas industries, the channels for recording and notification of occupational hazards in line with ILO policies, and inspection practices significantly ensure workers’ safety in the oil and gas industry. In line with the findings, it was suggested among others that management of oil and gas firms need to intensify efforts at ensuring that ILO policies and preventive measures are made available so as to adequately curb occupational health hazards and enhance workers’ safety.