Variance In Treatment Outcome Research Articles

Patient predictors of alcohol treatment outcome: A systematic review

Patient characteristics as predictors of alcohol use disorder treatment outcome were examined on three levels, identifying whether or not variables were significant predictors of drinking-related outcome in univariate analysis, in multivariate analysis, and in multivariate analyses limited to studies including several “key predictors.” Also, a model was developed to predict total percentage of variance in treatment outcome accounted for in each study using each of the key predictors and a range of methodological factors. The most consistent univariate predictors were baseline alcohol consumption, dependence severity, employment, gender, psychopathology rating, treatment history, neuropsychological functioning, alcohol-related self-efficacy, motivation, socioeconomic status/income, treatment goal, and religion. When these key predictors were combined into multivariate analyses, baseline alcohol consumption and gender showed substantial reductions in predictive consistency whereas the remaining variables were not greatly affected. The most consistent predictors overall were dependence severity, psychopathology ratings, alcohol-related self-efficacy, motivation, and treatment goal. The two predictor variables most associated with greater variance accounted for in predictive models, when controlling for broader methodological variables, were baseline alcohol consumption and dependence severity. Few predictor variables were examined in more than a third of studies reviewed, and few variables were found to be significant predictors in a clear majority of studies. However, a subset of variables was identified, which collectively could be considered to represent a consistent set of predictors. Too few studies controlled for other important predictor variables. Attempts to synthesize findings were often hampered by lack of agreement of the best measure for predictor variables.

Beyond parallel play: Science befriending the art of method acting to advance healing relationships.

Research underscores the central role of factors in healing that appear to relate to the therapeutic relationship. These nonspecific or common factors and placebo effects are often overshadowed by an emphasis in the field on particular empirically supported therapies. Yet relationship variables account for a greater proportion of the variance in treatment outcomes than the technical intervention employed, representing a notable blind spot in our science and, by extension, our practice. As a consequence, clinical instruction in psychology and in the health professions more broadly generally lacks adequate specificity with respect to how to cultivate a healing relationship. Through the elaboration of several techniques derived from theatrical traditions, the authors propose that method acting and similar schools of drama provide a method for honing clinical skills in these areas that is amenable to empirical scrutiny. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

Readiness to Change in a Clinical Sample of Problem Drinkers: Relation to Alcohol Use, Self-Efficacy, and Treatment Outcome

According to the transtheoretical model of behaviour change, individuals addicted to psychotropic drugs typically cycle through a sequence of five discrete stages (precontemplation, contemplation, preparation, action, and maintenance) before achieving sustained long-term abstinence and moderation, respectively. A number of English-language questionnaires have been developed to assess client motivation in accordance with the stages of change approach. The present study aimed to expand the research on the transtheoretical model by establishing the factor structure of a German-language version of the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES) in a large sample of alcohol-dependent inpatients (n = 350). Furthermore, the relation of client motivation to alcohol use, self-efficacy and treatment outcome at 3-month follow-up was examined. Exploratory factor analysis revealed three separate dimensions of readiness to change (Taking Steps, Recognition, and Ambivalence). The factorial structure of the German-language SOCRATES corresponded almost exactly to that of the original version. Readiness to change accounted for 9.4% of the variance in treatment outcome. Moreover, readiness to change was positively related to pretreatment self-efficacy.

The Influence of Demographic, Behavioural and Treatment Characteristics on Problem Gambling Counselling Outcomes

The paper considers the influence of client characteristics and gambling behaviour as well as treatment modality on the resolution of gambling behaviour for 591 clients who sought help from the publicly-funded BreakEven counselling services in the state of Victoria between 1 July 1996 and 30 June 1997. Statistical data about clients and their consultations was collected in the form of a Minimum Data Set. On their own, client demographics accounting for 12% of the variance were identified as discriminating between problem gamblers who achieved some resolution of their gambling behaviour and those whose behaviour did not change. Variables associated with gambling behaviour accounted for 10% of variance and treatment variables for 12% of variance in treatment outcomes. Collectively, the three types of data could explain 26% of the variance in problem resolution. Importantly, these findings demonstrate that the resolution of problematic gambling behaviour is affected by a complex interplay of client characteristics, their gambling behaviour and the treatment they receive. It is argued that the evaluation of treatment programs for problem gambling, and potentially all counselling programs in the primary health arena, needs to include measures from each of these domains.

Impact of comorbid personality disorders and personality disorder symptoms on outcomes of behavioral treatment for cocaine dependence.

Studies have revealed a significant adverse impact of comorbid personality disorders on treatment tenure and outcome in a variety of psychiatric and substance abuse populations. We investigated whether this negative relationship also exists among 137 urban, poor, cocaine abusers in behaviorally oriented treatment. Axis II diagnoses were generated categorically using the SCID-II as well as dimensionally using numbers of SCID-II symptoms within diagnostic categories. Contrary to expectations, there were no significant differences between subjects with and without various categorical personality disorders on any outcome measures. Categorical Axis II diagnoses were also minimally correlated with drug use severity, depression, and anxiety at intake, indicating that these were not potential coveriates of outcome. However, dimensional analyses of personality symptoms generated from the SCID-II accounted for substantial proportions of variance in treatment outcomes. Implications of these data for Axis II assessment and drug treatment planning are discussed.

The hypothalamic-pituitary-thyroid axis in major depression.

We investigated the capacity of several thyroid-axis measures to distinguish between depressed and control subjects and determined whether these variables were related to antidepressant treatment response. We studied 105 subjects who fulfilled the DSM-III-R criteria for a current major depressive episode and 41 volunteers with no current mental disorder. The following thyroid-axis variables were measured: difference between T4 levels at 09.00 hours and 13.00 hours; baseline TSH; maximal TSH response to 400 micrograms TRH (delta max TSH); and presence of a blunted delta max TSH. The T4 difference variable alone distinguished between depressed and control subjects. In multivariate analyses, T4 difference and delta max TSH were independently related to antidepressant-treatment outcome, and predicted a modest proportion (14%) of the variance in outcome. The relationship between these two variables and treatment outcome was particularly strong in depressed male subjects who were receiving desipramine, for whom they accounted for 36% of the variance in treatment outcome. The T4 difference variable both distinguished between depressed and control subjects and was related to treatment outcome. Although this finding requires replication, it is consistent with other reports of the usefulness of thyroid-axis indices measured at different times of day in depressed patients.

Response to light therapy in seasonal affective disorder: personality disorders and temperament as predictors of outcome

Outcome after 6 days of morning light therapy in subjects fulfilling criteria for winter seasonal affective disorder (SAD) was examined. Responders had significantly fewer previous episodes of SAD. Patients with a diagnosis of any DSM-III-R, axis II personality disorder, were significantly less likely to respond to light therapy than patients without axis II pathology. Poor treatment outcome was also significantly associated with: one or more personality disorders in cluster C, avoidant personality disorder, high number of positive criteria for self-defeating personality disorder and high score on the harm avoidance scale of the Tridimensional Personality Questionnaire. Temperament accounted for 25% of the variance in treatment outcome.

Respiratory training prior to exposure in vivo in the treatment of panic disorder with agoraphobia: efficacy and predictors of outcome.

Thirty-two patients suffering from panic disorder with agoraphobia were treated with repeated hyperventilation provocations and respiratory training, followed by exposure in vivo. The treatment was evaluated with a comprehensive set of outcome measures, including self-report questionnaires, a multitask behavioural avoidance test and continuous monitoring of panic. The treatment was found effective for the majority of patients in diminishing the frequency of panic attacks and agoraphobic avoidance. The clinical relevance of the treatment effect was evidenced by the considerable number of patients that recovered. The effect of the treatment was sustained over a three and six month follow-up period. The prognostic value of a number of variables for treatment outcome was also investigated. Three variables accounted for the majority of the variance in treatment outcome: a higher pretreatment level of agoraphobic complaints, use of psychotropic medication and a longer duration of the disorder were associated with poorer outcome. Other variables, such as the therapeutic relationship and the quality of the marital bond, had no prognostic value.

Temperament predicts clomipramine and desipramine response in major depression

Clinical predictors of drug response in major depression have been weak and inconsistent. Eighty-four patients suffering from a current major depressive episode completed a 6-week double-blind trial of either clomipramine or desipramine. Temperament, as measured by the Tridimensional Personality Questionnaire, accounted for 35% of the variance in treatment outcome, compared with less than 5% predicted by clinical variables. In the more severely depressed patients, temperament predicted nearly 50% of the variance in treatment outcome, which is the first time that such a substantial predictor of drug response has been identified. Within depressed women, temperament also predicted response to different antidepressant drugs. The potential importance of temperament, and the need for replication of these findings is discussed.

Research in clinical process and outcome methodology: Psychophysiology, systematic desensitization and dental fear

Eleven dental phobics were treated with a modified systematic desensitization procedure which included EMG biofeedback and videotaped scene presentations. During treatment, multiple psychophysiological recordings as well as subjective and psychometric assessments of mood were made. Intraindividual correlations between process variables were, to a large extent, idiosyncratic. Variance in treatment outcome could be accounted for by change-over treatment sessions of psychometrically assessed mood ( R 2 = .76) alone or in combination with change-over treatment sessions of minimum heart rate ( R 2 = .84). The process variable correlation patterns indicate a need for much more multivariate methodological research.

Predicting patients' perceptions of response to treatment for low-back pain.

An effort has been made to identify variables associated with favorable responses to treatment for low back pain. Using a series of 10 subjective measures, it was found that a rating given by the treating physician at the initial patient-physician contact correlated best with the patient's perception of response to treatment. Subscales from the MMPI and a pain drawing also correlated significantly with the patient's self report. Finally, it was noted that a multiple regression approach incorporating eight variables accounted for a significantly greater portion of the variance in treatment outcome than any single predictor.