Power transformers play a vital role in adjusting voltage levels during transmission. This study focuses on optimizing the structural design of power transformer tanks, particularly high-voltage (HV) tank walls, to enhance their mechanical robustness, performance, and operational reliability. This research investigates various stiffener designs and their impact on stress distribution and deformation through finite element analysis (FEA). Ten different configurations of stiffeners, including thickness, width, type, and position variations, were evaluated to identify the optimal design that minimizes stress and deflection while considering weight constraints. The results indicate that specific configurations, particularly those incorporating 16 mm thick H beams, significantly enhance structural integrity. Experimental validation through pressure testing corroborated the simulation findings, ensuring the practical applicability of the optimized designs. This study’s findings have implications for enhancing the longevity and reliability of power transformers, ultimately contributing to more efficient and resilient power transmission systems.