This study aims to test and analyze the influence of Tangible, Reliability, Responsiveness, Assurance, and Empathy on patient satisfaction at ABEPURA Regional Hospital. The population of this study was all inpatients at ABEPURA Regional Hospital, totaling 446 patients who were obtained from February to April 2017 who were in the inpatient room at ABEPURA Regional Hospital. The sampling method in this research uses an accidental sampling technique, namely sampling by taking cases or respondents who happen to be present or available according to the research context. In this study, the samples studied were 100 samples, which means 22.5% of the total number of subjects. The data analysis carried out in this research was multiple linear regression analysis. Based on the results of multiple linear regression analysis with a significance level of 5%, the results of this study indicate that: 1) Tangible has no significant effect on patient satisfaction at Abepura Regional Hospital. Reliability does not have a significant effect on patient satisfaction at Abepura Regional Hospital. 2) Responsiveness does not have a significant effect on patient satisfaction at Abepura Regional Hospital. 3) Assurance has a significant effect on patient satisfaction at Abepura Regional Hospital. 4) Tangibles do not have a significant effect on patient satisfaction at Abepura Regional Hospital. 5) Tangible, Reliability, Responsiveness, Assurance, and Empathy together simultaneously have a significant effect on patient satisfaction at Abepura Regional Hospital. Based on the results of this research, it is recommended: It is realized that research should be continuous so that it becomes complete research and can be used by all parties involved. This research still has shortcomings that can be studied again by future researchers, both in terms of qualitative and quantitative measurements by deepening the research object and adding other service quality variables that are not included in this research. So that further research will be better. It is hoped that the results of this research will be useful for nurses and hospital management so that they can improve the quality of service for better patient satisfaction. The service and motivation provided by nurses and other medical teams during the treatment period to patients can reduce anxiety so that patients will recover more quickly, this will influence patient satisfaction.