The goal of current study is to scrutinize the boundary layer flow of non-Newtonian Casson fluid flows on the slender parabola of revolution. Due to occurrence of temperature fluctuation in the flow analysis, the thermo-physical properties are presumed as variable. There is need to critically understand its behaviors in crude oil extraction, biomedical industries, textiles, papers, chemicals, machinery and many more processes. The assumed heat and mass transference is calculated by enthalpy change. The modeled equations of unsteady Casson fluid with variable fluid properties occur in the form of PDEs and Levy-Lees similarity transformations are used to convert them in ODEs form. The numerical solutions are calculated with a well-known method namely shooting technique. The variation in velocity field is noted due to the Casson fluid parameter, variable viscosity, suction coefficient and curvature parameter. The impression on temperature is noted by the variation in Damkholer number, thermal conductivity, curvature parameter, heat generation coefficient and Prandtl number. The concentration of fluid is noted due to the curvature parameter, Schmidt number, mass diffusion, Damkholer number and activation energy. At the end, the concluding remarks of the main findings are listed in conclusion section.