This study focuses on predicting fatigue crack paths and fatigue life in modified compact tension specimens, under mixed mode and variable amplitude loading conditions, using Machine Learning techniques. Mixed-mode conditions were induced by using specimens that incorporated holes with different radii and center coordinates. Initially, multiple Finite Element Method (FEM) simulations were conducted to determine the fatigue crack path for different configurations. Subsequently, several configurations were selected for experimental fatigue testing, in which the fatigue crack path was monitored and recorded. The final phase of the study involved Machine Learning (ML) techniques, specifically Artificial Neural Networks (ANN) and k-Nearest Neighbors (kNN), to predict fatigue crack propagation. The models were trained using different numerical and experimental data. Predicted results were then compared with experimentally tested data, and the behavior and accuracy of the models were evaluated. Overall, the implemented models demonstrated the ability to predict fatigue crack path with average deviations (ANN – 1.19 mm; kNN – 1.10 mm) closely resembling results obtained through Finite Element simulations (1.65 mm). The models were also able to predict fatigue life with average errors of 10.1 % (ANN) and 16.7 % (kNN), all achieved with a reduction of computational costs greater than 90 %.