Variable Habits Research Articles

Abstract 5463: The PD-L1 protein expression in Chinese patients with recurrent or metastatic head and neck squamous cell carcinoma: A multi-center retrospective study

Abstract Programmed death-ligand 1 (PD-L1) is a trans-membrane protein and co-inhibitory factor of the immune response. PD-L1 can combine with its receptor (PD-1) to reduce the proliferation of PD-1-positive cells and induce apoptosis. Therefore, PD-L1 was employed as a prognostic marker and a target for anti-cancer immunotherapy in blocking the PD-1 and PD-L1 checkpoints. PD-L1 is highly expressed in various malignancies, including head and neck squamous cell carcinoma (HNSCC). HNSCC is the sixth most common cancer worldwide, with high incidence and mortality rates in China. Although PD-L1 expression has been widely investigated, the PD-L1 expression status in Chinese HNSCC patients (pts) is largely unrevealed. The primary objective of this study was to determine the prevalence of PD-L1 expression with the Combined Positive Score (CPS) ≥20 in Chinese pts with recurrent or metastatic (R/M) HNSCC. The secondary objectives were to determine the prevalence of CPS≥1 in pts with R/M HNSCC and to study the difference in the demographic characteristics, clinicopathological parameters, treatment status, and other available biomarkers between the PD-L1 CPS≥20 group and the PD-L1 CPS<20 group. This study was a multi-center retrospective analysis of data from six centers in China from August 9, 2021, to February 28, 2022. Pts with histologically/cytologically confirmed diagnoses of R/M HNSCC were included. PD-L1 expression was assessed by IHC using the 22C3 PharmDx assay (Agilent, Santa Clara, CA, USA) and was determined using a CPS. The Chi-square test, Fisher’s exact test, or Wilcoxon rank sum test would be used to compare the prevalence of these variables among pts between the PD-L1 CPS≥20 group and the PD-L1 CPS<20 group. Out of 406 enrolled pts with R/M HNSCC, 402 testing pts were included in the final analysis. For all testing R/M HNSCC pts, 168 pts (41.8% [95% CI 36.92-46.78]) had PD-L1 expression with CPS ≥20. In addition, 337 pts (83.8% [95% CI 79.86-87.29]) had PD-L1 expression (CPS≥1). For the testing pts, there were statistically significant differences in variables of gender (P < 0.001), smoking habit (P = 0.0138 for non-smokers versus current smokers), and primary tumor site (P < 0.001 for hypopharynx versus oral cavity and P = 0.0304 for larynx versus oral cavity) between the PD-L1 CPS≥20 group and the PD-L1 CPS<20 group. In summary, in Chinese R/M HNSCC pts, most pts (83.8%) had PD-L1 expression, and two-fifths (41.8%) had PD-L1 expression with CPS ≥20. Prevalence of PD-L1 among Chinese pts with R/M HNSCC was consistent with that reported in the global KEYNOTE-048 study. PD-L1 expression was significantly associated with gender, smoking history and primary tumor site. Our findings of the variables related to the PD-L1 expression levels can supply adjuvant evidence for clinical practice and are a solid basis for future research on immunotherapy. Citation Format: Haizhen Lu, Dong Kuang, Lili Jiang, Jingping Yun, Qingxin Xia, Jian Wang, Pei Duan, Ping Zhou, Shengbing Zang, Yiping Jin, Xiangnan Jiang, Jielin Li, Wenmin Tang, Jiansong Zhou, Jihua Chen, Jianming Ying. The PD-L1 protein expression in Chinese patients with recurrent or metastatic head and neck squamous cell carcinoma: A multi-center retrospective study. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5463.

Structural equation modeling (SEM) analysis based on UTAUT2 theory on e-commerce adoption

E-commerce adoption with the UTAUT 2 model is a complex and multidimensional issue that connects multiple dimensions. A statistical method that can explain the relationship between one latent variable and another variable is Structural Equation Modeling (SEM). This study aims to create a structural model of e-commerce adoption using SEM based on indicators in the UTAUT2 theory. The data used in this study is primary data obtained through a survey of MSME actors in Batam City using a questionnaire with the purposive sampling method. The sample used was 200 MSMEs. The analysis results show that the value on the Behavioral Intention variable was 88.6%, and the Use Behavior variable was 76.8%. value of 97.4% indicates that the exogenous latent variable strongly affects the endogenous latent variable. The goodness of the fit value suggests that the SEM model in this study can explain empirical data or field data by 83%. The hypothesis testing results are that Behavioral intention significantly affects effort expectancy, facilitating condition, performance expectancy, and price value. Related to indirect effect, variables that affect user behavior through behavioral intention are significantly the variables of effort expectancy, facilitating condition, habit, performance expectancy, and price value.

Analysis of hair trace metal levels among workers at smelter limited company

Background: Lead (Pb) is one of the heavy metals that has a negative effect on the health of the human body and the environment. This metal is included in the 20 dangerous and toxic heavy metals defined by the Environmental Protection Agency (EPA) in 1997. One way to detect exposure to lead (Pb) in the body is to analyze the levels of lead in hair. The impact of exposure to lead (Pb) can cause neurological disorders, kidney function, reproductive system function, and nerve function.Purpose: To analyze lead levels through the hair of smelter workers at the smelting department of smelter limited company on Belitung Island, Bangka Belitung Islands Province.Method: Quantitative with cross-sectional method approach. The population in this study were workers at the smelter limited company smelting division. The object of research was 30 hair samples taken using a purposive sampling method. Data analysis was processed statistically so that the research data could be concluded as univariate, bivariate, and multivariate.Results: The Fisher's exact test showed a p-value of 1,000 so it could be concluded that there was no relationship between age and Pb levels in workers' hair. There is no relationship between working duration and Pb levels in workers' hair with a p-value > 1,000. That there is no significant relationship between length of service and Pb levels in the respondent's hair with a p-value of 0.469. There is a significant relationship between smoking habits, use of PPE, and work environment with lead levels in hair with a p-value of 0.023.Conclusion: There is no relationship between age, length of work, and years of service with Pb levels in the respondent's hair because the p-value is > 0.05. And there is a relationship between the variables of smoking habits, use of PPE, and work environment with Pb levels in hair with a p-value <0.05.

Effectiveness of video assisted teaching programme on knowledge and attitude regarding hemodialysis among patients with chronic renal failure

Chronic Renal Failure is a worldwide public health problem with an increasing incidence and prevalence, poor outcomes and high costs. The health teaching regarding hemodialysis and self care is important to improve the health and well being for patients with chronic renal failure. The aim of the study was to evaluate the effectiveness of video assisted teaching on knowledge and attitude regarding hemodialysis among patients with chronic renal failure. Pre experimental one group pretest post design was used. The setting of the study were out patient department at Dhanalakshmi Srinivasan Medical College and Hospital.50 samples were selected by non probability purposive sampling technique. After self introduction and explanation, the participants were given questionnaire to fill. The post test was done after the video assisted teaching, two weeks later. Result of the study were mean post test score of knowledge level 22.72 (SD±3.81)was significantly higher than the mean pre test score 14.31 (sd-3.67) and the mean difference were 8.38. Paired‘t’ value 28.28 (table value =2.02) which is significant ant p <0.05 level, for attitude, the mean post test score 74.66 (SD±7.31) was significantly higher than the mean pre test score 65.82 (sd-6.92) and the mean difference was 8.84. Paired “t” value of knowledge and attitude, the finding revealed that the mean value of knowledge is 22.72 with SD (3.81) and the mean value of attitude is 74.66 with SD (7.31) project ‘r’ value of 0.329 (table value=0.273) which shows positively mild correlation. The result reveals that there is a significant association between the knowledge and the demographic variables of food habits, educational qualification and duration of dialysis and significant association between the attitude and the demographic variables of age and educational qualification (table value =3.84, p <0.05). The finding revealed that there is a significant improvement in knowledge and attitude after intervention. Imprint Dhanalakshmi J, Malathi S. Effectiveness of video assisted teaching programme on knowledge and attitude regarding hemodialysis among patients with chronic renal failure.

Influence of Study Habit on the Academic Performance of Biology Students in Senior Secondary Schools in Port Harcourt Metropolis, Rivers State

The study investigated study habits on academic performance of students in Biology in senior secondary schools in Port Harcourt Metropolis of Rivers State. Four research questions were formulated to guide the study. A descriptive research design was used in the study. Two Hundred and fifty (250) students were randomly selected from five secondary schools in Port Harcourt metropolis. Study Habits and Academic Performance Questionnaire (SHAPQ) was the instrument for data collection. The data collected for the studies were analyzed using frequency counts and mean for the research questions. In computing the mean (X), the response alternatives were assigned on a 4-point Likert scale. The scaling point was used to describe the extent to which the respondents perceived each item. Based on the values, the mean (X) was used to determine the acceptance or rejection of the items. Any item with a mean score of 2.50 and above is a benchmark for acceptance. The findings of this study revealed that allocation of study time, note-taking, learning motivation and memorization are variables of study habits that contribute to students’ academic performance in Biology in senior secondary schools in Port Harcourt Metropolis, Rivers State. It is recommended that Students should be committed to the variables of study habit that will help to improve the study habits of secondary school students on Biology with the help of education Policy makers, Teachers and Parents.

The role of socio-demographic variables and buying habits in determining milk purchasers' preferences and choices.

Emerging new purchasing behaviors have been reflected in the sales trends of dairy products, mainly in cow milk consumption. This study aimed to investigate the preferences of milk purchasers toward different product attributes, by considering both individuals' socio-demographic characteristics (SD) and milk purchasing habits (PH) as independent variables in the milk consumption model definition. To achieve this objective, a questionnaire was administered to a sample of 1,216 residents in Northwest Italy. The application of the Best-Worst scaling (BWS) methodology to define the purchasers' declared preferences toward a set of 12 milk attributes, showed that milk origin and expiry date are the most important attributes for milk choice in the decision-making process. The correlation analysis showed that the SD and milk purchasing habits variables affect the definition of stated preferences heterogeneously between the intrinsic, extrinsic, and credence attributes.

Theoretical basis and occurrence of internet fraud victimisation: Based on two systems in decision-making and reasoning.

The influencing factors of internet fraud, including demographics, psychology, experience and knowledge of susceptibility, have been widely studied. Research on the psychological mechanism of the victimisation process of internet fraud is relatively scarce but suggests a new research perspective. To summarise and unify the research in this field, this study systematically searched and analysed articles on the psychological decision-making mechanism of online fraud victims. We found that (a) previous researchers consistently believed that the heuristic processing mode was correlated with susceptibility to online fraud and that the systematic processing mode was helpful to detect and identify fraud. From the overall review results, we do not reject this conclusion, but the verification and intrinsic explanation of this relationship need to be further strengthened. (b) Under the heuristic-systematic model (HSM), with the exception of the trait of suspicion, there is no consensus on whether psychological factors (e.g., personality) influence the likelihood of online fraud through the mediating effect of the selection of the two systems. Objective knowledge and experience in specific fields have been found to be able to achieve this path. Information on the influential variables of equipment and habits is emerging, but how they affect network victimisation through the heuristic processing system needs to be further clarified. (c) The measurement of variables is conducted through simulation experiments. There may be a gap between the likelihood of internet fraud victimisation in the simulation experiment and in the real world. (d) The defence strategies under the HSM are intentional explorations, such as content-based cue recognition technology and simulated scene training.

ANALYSIS OF FINANCIAL INCLUSION THROUGH FINTECH INNOVATION

This study aims to explain the intention in using mobile money through the application of the Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2) model. This research was conducted throughout the Solo Raya community. The number of samples in this study were 100 respondents. The data collection method used non-probability sampling with purposive sampling in which the researcher determines sampling by providing specific criteria. The research data was obtained through a survey method with a questionnaire technique. The analytical tool used to test the hypothesis was path analysis with the help of SmartPLS 3.0. The results show that the variable performance expectations, effort expectations, social influence, hedonic motivation, and facility conditions have no significant effect on the intention to use mobile money. Price value and habit variables have a positive and significant effect on the intention in using mobile money.

Correlation Of Self-Regulation And Learning Habits With Student's Thesis Writing Skills

This study aims to determine the correlation between self-regulation and study habits with thesis writing skills of students at the Kupang State Christian Institute. The study used a quantitative approach with the correlational method. The population in this study amounted to 248 people consisting of semester IX students, while the research sample amounted to 71 people who were calculated using the Slovin formula. Data was collected through distributing questionnaires and then continued with carrying out data processing using statistical techniques. Based on the results of the correlation analysis of the three variables, the coefficient price of 0.311 is obtained, it can be said that between the variables X1 and X2 with Y has a significant correlation, then from the analysis results also obtained the coefficient of determination (r-square) of 0.097 or equivalent to 9, 7%. This means that the correlation between self-regulation and study habits with thesis writing skills for students of the State Christian Institute of the State Christian Institute of Kupang is 9.7% and the remaining 90.3% is caused by other factors outside the variables of self-regulation and study habits. . From these results, the researcher can draw the conclusion that the alternative hypothesis (Ha) is accepted.

Faktor-Faktor yang Mempengaruhi Penggunaan Aplikasi E-Wallet Dana Di Kota Samarinda

ABSTRACT This study develops the Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2) model. UTAUT 2 consists of the variables of performance expectancy, effort expectancy, social influence, facilitating conditions, hedonic motivation, price value, habit, behavioral intention, and use behavior. This study aims to examine the effect of the factors in the UTAUT 2 model on user behavior in using the DANA e-wallet application.This study uses a quantitative approach with an explanatory type. A sample of 90 users of the DANA application in Samarinda City was selected by accidental sampling. The causality test uses partial least squares.The results showed that performance expectancy and price value have positive and significant effects on behavioral intention; habit and behavioral intention have positive and significant effects on use behavior; effort expectancy and facilitating conditions have negative and insignificant effects on use behavior; social influence has negative yet significant effect on behavioral intention; and hedonic motivation has positive but not significant effect on behavioral intention. Keywords: UTAUT 2, Performance Expectancy, Effort Expectancy, Social Influence, Facilitating Conditions, Hedonic Motivation, Price Value, Habit, Behavioral Intention, Use Behavior

Risk Factor of Low Back Pain in the Informal Sector Tailor in Solor Kupang City 2019

Tailor is a risky job that impact to low back pain. Low back pain (LBP) can cause a tailor to experience a decrease in the ability to perform daily activities and occupational health problems. One of the low back pain risk factors is individual factors include body mass index (BMI), exercise habits, and working period. This research was observational analytical research with a cross-sectional design conducted at Informal Sector tailor in Solor, Kupang City by filling questioner, body mass index measurement, and direct interview. The sampling technique used was total sampling with 48 samples that fulfilled inclusion and exclusion criteria. The data were analyzed by using the univariate, bivariate with chi-square, and multivariate with logistic regression as well. The bivariate analysis results showed that the results were significant on the variable of body mass index (p=0.012, OR=5.667) and work period (p=0.026). While there was no significant correlation between the variables of exercise habits with the incidence of low back pain (p=0.407).The multivariate analysis results found that the variable of the work period was the variable that had the biggest effect on the incidence of low back pain (OR=0.361). There are correlations between body mass index and work period with low back pain incidence at Informal Sector tailor in Solor, Kupang City in 2019.

Demographic and Clinical Profile of Oral Submucous Fibrosis: A Retrospective Study

BACKGROUND: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder which is irreversible in nature and has high morbidity and high malignant transformation rate and hence demands focus on prevention of the disease at population and individual level. AIMS: Assessment of risk factors and the role of habit variables such as duration and frequency in the severity of OSMF and to ascertain the association of gender predilection for different habits and severity of OSMF. MATERIALS AND METHOD: This descriptive retrospective study of 1801 OSMF patients was carried out at the Dental hospital in the rural population of Gwalior region. The clinicodemographic data including details of habits was collected for a period of 5 years, from January 2016 to December 2021. Collected data was analysed using Systat version 12 software. RESULTS: The average age of the patient in the study was 32.8 years, with 16.5:1 M:F ratio. Significantly higher proportions of females (69.6%) were illiterate and belonged to low socioeconomic status. There was a statistically significant increase for areca nut chewing (OR=0.135(0.054-0.342), P < 0.0001), gutkha chewing (OR=22.32(10.421-47.817), P < 0.0001), tobacco chewing (OR= 0.111(0.04-0.308), p<0.0001), smoking habits (OR=30.791(7.472-126.89), P < 0.0001) and alcohol (OR=12.692(3.077-52.347, p < 0.0001) in males when compared with females. The maximum patients were seen in stage II (37%) and stage III (34%), followed by stage I (18.73%) and stage IV (10.3%) and the severity of OSMF was more in subjects who had the habits for longer duration. CONCLUSION: There was a definite gender predilection for various habits and their variables (frequency, duration), educational and socioeconomic status, clinical features and disease severity. Significant correlation was also found between habit variables (duration, frequency) and severity of the disease.

FAKTOR RISIKO KEJADIAN HIPERTENSI PADA USIA DEWASA MUDA (20-44) DI WILAYAH KERJA PUSKESMAS KANDAI TAHUN 2022

Hypertension is a body condition where there is an increase in systolic blood pressure 140 mmHg or systolic blood pressure ≥ 90 mmHg. This study aims to determine the risk factors for family history, physical activity, obesity and smoking habits at the Kandai Health Center in 2022. This study used design case control. The population in this study were all patients who came for treatment at the Kandai Health Center in 2022. The sample in this study was 120 consisting of 60 cases and 60 controls, sampling using simple random sampling technique. The results showed that family history obtained an OR = 99 (CI; 28,512-334,751), physical activity obtained a value of OR = 0.655 (CL; 0.246-9.478), obesity obtained an OR = 2.466 (CI; 0.193-0.853), and habits smoking obtained OR value = 1.238 (CL; 0.590-2.596). From the 120 research samples used, it can be concluded that the variables of family history, obesity, and smoking habits are risk factors for the incidence of hypertension in the work area of the Kandai Public Health Center in 2022, while the physical activity variable is not a risk factor for the incidence of hypertension

Clean and Healthy Life Behavior (PHBS) of Elementary School Students Against Environmental-Based Disease Incidence in Kupang City in 2021

School-age is a period of vulnerability to diseases such as diarrhea, intestinal worms, caries, and anemia. This research is an analytical observational study with a cross-sectional research design with a sample of 937 elementary school students spread throughout the city of Kupang. The data analysis technique used the Chi-square test to determine the relationship between the variables studied with significant values with the help of the SPSS program. The incidence of environmental-based disease experienced by elementary school students is diarrhea and the lowest is malaria. The personal hygiene variable shows a good category, and the results of statistical tests show no relationship between personal hygiene and the incidence of environmental-based diseases. The results also show a relationship between the consumption of healthy food and the incidence of environmental-based diseases. The variable of using healthy latrines is in a good category. There is a relationship between the use of clean and healthy latrines with the incidence of environmental-based diseases. The variable presence of mosquito larvae showed free of larvae. The waste disposal variable shows that the highest level of waste disposal in the respondent's house indicates the category is not good. Hygiene variables, the presence of larvae, and waste disposal have no relationship with the incidence of environmental-based diseases in elementary school children, while the variables of healthy food consumption habits and use of latrines have a relationship with the incidence of environmental diseases. Disease-based primary school children.

Comparison between self-reported smoking habits and daily ad-libitum smoking topography in a group of Korean smokers.

Tobacco smoking is associated with a high global mortality rate since it is known to cause cancers and lung and heart diseases. To control and reduce annual mortality attributed to smoking, it is essential to design applicable smoke cessation programs based on realistic tobacco exposure risk assessment. In this regard, understanding the smoking habits of the smoker is crucial. Using self-report smoking habit surveys is a common approach in measuring basic variables of smoking habits. However, smoking topography measurement devices have recently become available for investigating smoking habit variables accurately. In this study, we conducted a self-report survey to investigate a group of Korean smokers’ smoking habit variables such as the number of smoked cigarettes per day, puff counts, and total smoking time. The survey also included items from the Fagerström Test for Nicotine Dependence (FTND). The results were compared with the corresponding variables from machine-determined data to investigate their correlation and reliability. Results indicate that Korean smokers have a reliable understanding of the average number of cigarettes they smoke daily (ρ = 0.517, Cronbach’s α = 0.754) and the time to first cigarette (TTFC) after waking up (ρ = −0.587, Cronbach’s α = 0.623), as fundamental items of the FTND score. Nevertheless, these smokers significantly under-reported the puff number and total smoking time, which can cause significant underestimation in the tobacco exposure risk assessment. Consequently, we suggest the application of self-report surveys that are based on the amount of daily smoked cigarettes (e.g. FTND) for clinical or risk assessment purposes. Using smoking topography measurement devices is recommended overusing self-report surveys in measuring smoking habit variables such as puff count and smoking time more accurately.

KEPUTUSAN DAN PREFERENSI KONSUMEN : PINANG KERING IRIS DI PERBATASAN (StudiKasus: Kabupaten Timor Tengah Utara)

Betel nut consumption in North Central Timor Regency lasted a long time and continues to grow to this day. The study aims to determine the factors that influence consumer decisions and consumption preferences of iris dried betel nut in north Central Timor border communities. This research was conducted in January-February 2022.The data analysis method used is qualitative descriptive and logistic regression analysis. The variables of age, sex, habits, taste, and texture together affect the consumption preferences of iris dried betel nut. The age and texture of the iris dried betel nut significantly affect the decision of the people of East Miomaffo Subdistrict in consuming slice dry betel nut. Texture becomes the preference of consumers to choose the dried betel nut of the iris consumed.

Factors Affecting MinaIndividuals Using Sharia Financial Technology (Fintech) in Medan City Community

This study aims to identify the factors that influence the interest of the people of the city of Medan in using Sharia Fintech . This study uses a quantitative descriptive approach. The population in this study were all the people of the city of Medan who met certain criteria as many as 70 people. Instruments and data collection is done by giving a questionnaire directly to the respondents. This study uses multiple linear regression analysis techniques, t test, F test, and the coefficient of determination. Based on the results of the multiple linear regression equation Y = -6.547 + 0.258 X 1 + 0.255 X 2 + 0.301 X 3 + 0.150 X 4 + 0.916 X 5 where the variables of social factors, trust, sharia compliance, security guarantees and habits have an influence on individual interest variables . Based on the results of the partial test (t test) shows that social factors have a positive and significant effect on individual interest. It can be seen from r count > r table ( 4.201 > 1.997) with a significant level of 0.000 < 0.05. Based on the results of the coefficient of determination test, it is known that the R square value is 0.646. This means that the influence of social factors, trust, sharia compliance, security guarantees and habits on individual interests is 64.6%, while the remaining 35.4% is influenced by other variables not included in this study.

Millennials Adpot Online Delivery: Analysis Using UTAUT2 Model During Pandemic Covid-19

The COVID-19 pandemic that has hit since the beginning of 2020 has forced the government to issue a social distancing policy . This policy dampens the economic activity of the community, including buying and selling transactions, to the use of online payment systems to make it easier for people to meet their needs from home. This study aims to analyze the determinant factors that influence Behavior Intention on the use of online delivery systems using the UTAUT 2 method. The object of this research is dominated by the millennial generation who have more user experience. The independent variables studied in this study were Performance Expectancy (PE), Effort Expectancy (EE), Social Influence (SI), Facilitating Conditions (FC), Price Value (PV), Hedonic Motivation (HM), and Habit (H) towards Behavior Intention (BI) using PLS-SEM analysis technique. The results of this study indicate that the variables of Performance Expectancy, Price Value, and Habit have a positive effect on Behavior Intention while other factors have no effect on Behavior Intention.

Pharmacists' mental health during the SARS-CoV-2 pandemic in Italy.

The year 2020 was characterized by the outbreak of a new pandemic caused by a novel coronavirus named SARS-CoV-2. To face the pandemic, many countries worldwide imposed general lockdowns, closing all non-essential businesses. As primary care services, pharmacies had to remain open, thus putting pharmacy staff at significant risk of viral infection and overwork. This study aimed to assess the mental health of Italian Pharmacists, considering demographic and occupational characteristics, lifestyle, and habits, during the SARS-CoV-2 outbreak and the subsequent lockdown period (March-May 2020). A web-based survey was created using Google® Forms to collect data from March 30, 2020, to June 1, 2020. The questionnaire consisted of three sections investigating: (1) demographic and occupational variables, (2) lifestyle and habits variables, (3) psychological distress and perceived well-being. A total of 401 participants completed the questionnaire. Older workers and those with more work experience reported more psychological stress. Older and female workers, who felt lonely at home and reported psychological stress, perceived poor well-being. Our findings demonstrate that the Sars-CoV-2 outbreak and subsequent lockdown rules affected pharmacists' mental health and that it is important to put in place preventive measures against the occurrence of mental disorders among them.

Analysis of the Factors That Influence the Behavior of the Millennial Generation to Use the Go PAY Digital Wallet

The purpose of this research is to empirically prove the "Unified Theory Of Acceptance And Use Of Technology 2" model on the behavior of the millennial generation to use the Go-PAY Digital Wallet. This study uses primary data collected by questionnaires distributed through self-managed twitter media involving a sample of 185 respondents from Go-Pay users in Indonesia. Methodology of data analysis was carried out using the SEM approach using SmartPLS 3 tools. The results of this study found that only the Habit Variable, Price Value had a positive and significant influence on the intention to use Go-Pay while the Job Expectation Variable, Supporting Conditions, Hedonic Motivation, Social Influence, Perceived Risk and System Related Privacy does not have a significant effect. Meanwhile, to see the Usage Behavior, only the variables of Habits, Supporting Conditions, Interest in Use have a positive and significant effect, while the others do not have a significant effect. The results of this study are expected to provide references and information to Go-PAY companies regarding the interests and behavior of the Millennial Generation in using Go-PAY so that the results of this study can be used as a strategic guideline model for the future development of Go-PAY and other Fintech companies in Indonesia. Indonesia.