Given a Serre class $\mathcal {S}$ of modules, we compare the containment of Koszul homology, Ext modules, Tor modules, local homology and local cohomology in $\mathcal {S}$ up to a given bound $s \geq 0$. As applications, we give a full characterization of Noetherian local homology modules. Furthermore, we establish a comprehensive vanishing result which readily leads to formerly known descriptions of the numerical invariants' width and depth in terms of Koszul homology, local homology and local cohomology. In addition, we recover a few renowned vanishing criteria scattered throughout the literature.