The major purpose of this paper is to study the important role of historical painting art on the creation of space-age era eight decades ago in 1950s. According to the Merriam-Webster Dictionary, the first known use of “space age” was in 1946. In the Collins Dictionary, the space age is the present period in the history of the world when travel in space has become possible, and people use “space-age” to describe something that is very modern and makes you think of the technology of the space age. In American English, space age is the period in modern history characterized by space exploration, usually considered as beginning on October 4, 1957, when the Soviet Union launched the first artificial satellite, Sputnik I, into orbit around the Earth. In the ancient time, many artists including Giovanni di Paolo, Albrecht Dürer, Étienne Léopold Trouvelot and Vincent van Gogh created masterpieces of space related paintings. Even in the extreme ancient era, the cave art already evidenced humans’ astronomical knowledge. Besides the technological research and development for space explorations, groups of workers and artists in the areas of culture, painting, architects, installation artwork, etc. had done many contributions in the development of space-age cultural and aesthetic art before 1950s. They not only created so many masterpieces with plenty of space-age aesthetics, but witnessed and recorded the development history of the space age. It goes without doubt that historical space painting art played an important role on the creation of space-age era in 1950s. Therefore, it is mandatory to investigate and reveal the fact.