A real-time modeling and control architecture for coupled shear layer von Karman instabilities on a wing section wake is developed. Previous wind tunnel experiments highlighted that these wake instabilities give rise to limit cycles on both local and resulting airloads. The two-state Van der Pol system is employed to model the self-sustained oscillations exhibited by the actual flow. Schemes featuring either one or two coupled Van der Pol oscillators in parallel are taken under consideration. Open-loop and closed-loop control laws to manipulate and reduce the self-sustained oscillations are extensively studied. An adaptive control scheme is developed to optimize the performance of the controller, according to the flow conditions. For the open-loop control scheme, the consistency with experimental tests performed on a wind tunnel model is shown.