Van Calster Research Articles

Triaging women with ovarian masses for surgery: observational diagnostic study to compare RCOG guidelines with an International Ovarian Tumour Analysis (IOTA) group protocol

To compare guidelines from the Royal College of Obstetricians and Gynaecologists (RCOG) based on the Risk of Malignancy Index (RMI) with a protocol based on logistic regression model LR2 developed by the International Ovarian Tumour Analysis (IOTA) group for triaging women with an ovarian mass as low, moderate, or high risk of malignancy. Observational diagnostic study conducted between 2005 and 2007 at 21 oncology referral centres, referral centres for ultrasonography and general hospitals. In all, 1938 women undergoing surgery for an ovarian mass. RCOG guidelines use the RMI to triage women as low (RMI < 25), moderate (25-250), or high (above >250) risk. The IOTA protocol uses LR2s estimated probability of malignancy (<0.05 indicates low risk, ≥ 0.05 but <0.25 moderate risk, and ≥ 0.25 high risk). Percentages of benign, borderline and invasive tumours classified as low, moderate or high risk. The IOTA and RCOG protocols classified 71.1% and 62.1% of benign tumours as low risk, respectively (difference 9.0; 95% CI 6.2-11.9, P < 0.0001). Of invasive tumours, 88.6% and 73.6% were labelled high risk (difference 15.0; 10.6-19.4, P < 0.0001), and 3.0% and 5.2% were labelled low risk (difference -2.2; -4.6 to 0.2, P = 0.07) respectively by each protocol. Similar results were found after stratification for menopausal status. The IOTA protocol was more accurate for triage than the RCOG protocol. The IOTA protocol would avoid major surgery for more women with benign tumours while still appropriately referring more women with an invasive tumour to a gynaecological oncologist.

Primary yolk sac tumor of the endometrium

[1] Van Calster B, Timmerman D, Bourne T, Testa AC, Van Holsbeke C, Domali E, et al. Discrimination between benign and malignant adnexal masses by specialist ultrasound examination versus serum CA-125. J Natl Cancer Inst 2007;99(22): 1706–14. [2] Valentin L, Jurkovic D, Van Calster B, Testa A, Van Holsbeke C, Bourne T, et al. Adding a single CA 125 measurement to ultrasound imaging performed by an experienced examiner does not improve preoperative discrimination between benign and malignant adnexal masses. Ultrasound Obstet Gynecol 2009;34(3): 345–54. [3] Guerriero S, Ajossa S, Gerada M, Virgilio B, Pilloni M, Galvan R, et al. Transvaginal ultrasonography in the diagnosis of extrauterine pelvic diseases. Expert Rev Obstet Gynecol 2008;3(6):731–52.

Governing Nanomedicine: Lessons from within, and for, the EU Medical Technology Regulatory Framework. Guest Editors Introduction

Law & PolicyVolume 33, Issue 2 p. 215-224 Governing Nanomedicine: Lessons from within, and for, the EU Medical Technology Regulatory Framework. Guest Editors Introduction BÄRBEL R. DORBECK-JUNG, BÄRBEL R. DORBECK-JUNG University's Institute for Governance Studies (IGS)Search for more papers by this authorDIANA M. BOWMAN, Corresponding Author DIANA M. BOWMAN Melbourne School of Population Health, The University of MelbourneDiana M. Bowman, Melbourne School of Population Health, The University of Melbourne 3010, Melbourne, Victoria 3800, Australia. Telephone: +61 3 8344 0885; Fax: +61 3 9348 1174; E-mail: [email protected]. Search for more papers by this authorGEERT VAN CALSTER, GEERT VAN CALSTER University's Institute for Governance Studies (IGS)Search for more papers by this author BÄRBEL R. DORBECK-JUNG, BÄRBEL R. DORBECK-JUNG University's Institute for Governance Studies (IGS)Search for more papers by this authorDIANA M. BOWMAN, Corresponding Author DIANA M. BOWMAN Melbourne School of Population Health, The University of MelbourneDiana M. Bowman, Melbourne School of Population Health, The University of Melbourne 3010, Melbourne, Victoria 3800, Australia. Telephone: +61 3 8344 0885; Fax: +61 3 9348 1174; E-mail: [email protected]. Search for more papers by this authorGEERT VAN CALSTER, GEERT VAN CALSTER University's Institute for Governance Studies (IGS)Search for more papers by this author First published: 08 March 2011 https://doi.org/10.1111/j.1467-9930.2010.00335.xCitations: 4Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume33, Issue2April 2011Pages 215-224 RelatedInformation

Assessment of Improved Prediction Beyond Traditional Risk Factors

The moderate predictive performance of cardiovascular disease risk models necessitates more studies that investigate the incremental value of novel biomarkers. In recent years, many new biomarkers have been evaluated for their ability to improve prediction of cardiovascular disease beyond traditional risk factors, including C-reactive protein, coronary artery calcium, and single-nucleotide polymorphisms in the 9p21 region.1 The interest in novel biomarkers is propelled, in part, by emerging discoveries from genomewide association studies of genetic variants associated with risk for many common diseases.2 Nonetheless, family history, an “old” tool in clinical practice—crucial for the diagnosis and management of genetic disorders—has not been adequately explored for its value in risk assessment and prevention of common diseases.3 Positive family history is a strong risk factor for cardiovascular diseases,4,5 reflecting the consequences of genetic and nongenetic risk factors that are shared among relatives. From a practical perspective, family history is a strong determinant of disease that is relatively easy to assess. For this reason, family history is advocated as a useful tool for identifying individuals at increased risk of disease and for tailoring preventive interventions.4,6,7 However, the challenge is to show that this knowledge has clinical utility for improving health.8 Article see p 97 In this issue of Circulation: Cardiovascular Genetics , Scheuner et al9 report the incremental value of adding family history information to the General Cardiovascular Risk Profile to improve identification of individuals with advanced coronary artery calcification. The incremental value of family history in disease prediction is assessed in several questions10: 1. Does family history improve prediction beyond traditional risk factors? 2. Does improved prediction change treatment decisions or health recommendations? 3. Do these changes improve health outcomes or have other benefits? 4. Do the incremental benefits outweigh the extra costs? This evaluation is a stepwise …

18th World Congress on Ultrasound in Obstetrics and Gynecology, 24–28 August 2008, Chicago, USA: presentations and awards

When asked to introduce Larry Platt as the 2008 Gold Medal recipient, I was more than delighted to do so. One might consider this to be a daunting task. However, since Larry’s career is so robust, it was actually easy to chronicle his contributions through the years. To me, the Ian Donald Gold Medal Award is the greatest honor that one can receive in our field of obstetric and gynecological ultrasonography. Since it carries so much respect, when I heard that Larry Platt was this year’s recipient I thought to myself, ‘it’s about time’. Why? Firstly, Larry has been a prolific contributor to the literature. Secondly, he has been a tenacious supporter of ultrasound education. And thirdly, aside from Stuart Campbell, I can think of no one who has been a greater advocate for ISUOG. He has served as President of the Society, Associate Editor of Ultrasound in Obstetrics and Gynecology, and has been on the Board for many years; he has simply put ISUOG first, ahead of his many other responsibilities. When I recently thumbed through my most recent book on ultrasound, I found that I had cited Larry’s work in five different chapters. First and foremost, one cannot mention his name without connecting it to the wonderful contribution that he and Frank Manning made in designing the biophysical profile. It is hard to believe that this was published 28 years ago, and is still being used in its original form by virtually everyone managing

XI. Reports from International Courts and Tribunals

Journal Article XI. Reports from International Courts and Tribunals Get access Paolo Galizzi, Paolo Galizzi Search for other works by this author on: Oxford Academic Google Scholar Wim Vandenberghe, Wim Vandenberghe Search for other works by this author on: Oxford Academic Google Scholar Geert van Calster, Geert van Calster Search for other works by this author on: Oxford Academic Google Scholar Ted L. McDorman, Ted L. McDorman Search for other works by this author on: Oxford Academic Google Scholar Sergio Peñ-Neira Sergio Peñ-Neira Search for other works by this author on: Oxford Academic Google Scholar Yearbook of International Environmental Law, Volume 19, Issue 1, 2008, Pages 625–646, https://doi.org/10.1093/yiel/19.1.625 Published: 01 January 2009

XI. Reports from International Courts and Tribunals

XI. Reports from International Courts and Tribunals Get access Paolo Galizzi, Paolo Galizzi Search for other works by this author on: Oxford Academic Google Scholar Wim Vandenberghe, Wim Vandenberghe Search for other works by this author on: Oxford Academic Google Scholar Geert van Calster, Geert van Calster Search for other works by this author on: Oxford Academic Google Scholar Ted L. McDorman, Ted L. McDorman Search for other works by this author on: Oxford Academic Google Scholar Jonathan G. Dorn Jonathan G. Dorn Search for other works by this author on: Oxford Academic Google Scholar Yearbook of International Environmental Law, Volume 18, Issue 1, 2007, Pages 605–634, https://doi.org/10.1093/yiel/18.1.605 Published: 01 January 2008

Re-visiting the informal economy: Introductory notes

The informal economy is one of the more elusive objects in social research. By that we don’t just mean to state the obvious about an object which has, as Stuart Henry and Stephen Sills in their contribution to this issue have been at pains to point out, also become known as the ‘hidden’, ‘subterranean’, or indeed ‘shadowy’ side of economic life and the world of value exchange. The word elusive here could refer to the severe problems researchers and scholars have experienced – and continue to experience – when trying to define the object called ‘informal economy’. A great number of definitions abound. Again Henry and Stills, in this issue, provide a compelling historical overview of attempts that have been made to locate and define one or more common features in a dazzling variety of practices, motivations, habits, strategies and tactics. Often such attempts at definition have tended to converge on or about the rather basic notion of informal economy as economic activity which is unregulated, uncontrolled and/or non-enforced by either the State or other (public) authorities. But even such straightforward definitions cannot eliminate the phenomenon’s elusiveness. Not just because underneath blanket definitions this great variety of practices, motivations, habits, strategies and tactics persists, but also because, on the ground, in the minds and practical schemes of economic actors, these very practices and motivations and so on tend to be quite similar to those in the ‘formal’ economy, and even where and when they are not, one often finds them almost inextricably intertwined – across the formal/ informal divide – in the everyday of economic life. As Patrick Van Calster in his contribution to this issue demonstrates, focusing on the illegal informal economy and on organized crime, the microscopic study and analysis of the more mundane aspects of everyday economic life may reveal how practical concerns of and minute decisions by economic actors weave an almost inextricable pattern of practices across the formal/ informal divide. This is also the case in workplace cultures. As Gerald Mars, in his Crime Law Soc Change (2006) 45:259–261 DOI 10.1007/s10611-006-9035-3

European Case Law Report October 2003–March 2004

Review of European Community & International Environmental LawVolume 13, Issue 2 p. 223-226 European Case Law Report October 2003–March 2004 First published: 17 June 2004 https://doi.org/10.1111/j.1467-9388.2004.00399.x Written by: Prof. Dr Geert van Calster, Collegium Falconis, K.U. Leuven, Member of the RECIEL Editorial Board; Member of the Brussels Bar, DLA Caestecker; and Maria Lee, Lecturer in Law, King's College London. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume13, Issue2July 2004Pages 223-226 RelatedInformation

Current noise is thick and thin film resistors: S Demolder, A van Calster and M Van-Dendriessche Electrocomponent Sci. Technol. 19, 81 (1983)

Current noise is thick and thin film resistors: S Demolder, A van Calster and M Van-Dendriessche Electrocomponent Sci. Technol. 19, 81 (1983)

Current noise is thick and thin film resistors: S. Demolder, A. Van Calster and M. Vandendriessche Electrocomponent Sci. Technol. 19, 81 (1983)

Current noise is thick and thin film resistors: S. Demolder, A. Van Calster and M. Vandendriessche Electrocomponent Sci. Technol. 19, 81 (1983)

Current noise is thick and thin film resistors: S. Demolder, A. Van Calster and M. Van-Dendriessche Electrocomponent Sci. Technol. 19, 81 (1983)

Current noise is thick and thin film resistors: S. Demolder, A. Van Calster and M. Van-Dendriessche Electrocomponent Sci. Technol. 19, 81 (1983)

Current noise in thick and thin film resistors : S. Demolder, A. Van Calster and M. Vandendriessche. Electrocomponent Sci. Technol.19, 81 (1983)

Current noise in thick and thin film resistors : S. Demolder, A. Van Calster and M. Vandendriessche. Electrocomponent Sci. Technol.19, 81 (1983)

State of the art in thin film transistor: a review of the used insulator-semiconductor combinations: Andre van Calster and Alexis de Vos. Electrocomp. Sci. Technol.6, 131 (1980)

State of the art in thin film transistor: a review of the used insulator-semiconductor combinations: Andre van Calster and Alexis de Vos. Electrocomp. Sci. Technol.6, 131 (1980)

A channel conductance measuring technique for determining the interface properties of a SiO-InSb thin film transistor: A. van CALSTER Solid-St. Electron.21, p.393 (1978)

A channel conductance measuring technique for determining the interface properties of a SiO-InSb thin film transistor: A. van CALSTER Solid-St. Electron.21, p.393 (1978)

A channel conductance measuring technique for determining the interface properties of a SiO-InSb thin film transistor : A. van Calster. Solid-St. Electron.21, 393 (1978)

A channel conductance measuring technique for determining the interface properties of a SiO-InSb thin film transistor : A. van Calster. Solid-St. Electron.21, 393 (1978)

Theoretical influence of surface states and bulk traps on thin film transistor characteristics : A. Van Calster and H. J. Pauwels. Solid-State Electron.18, 69 (1975)

Theoretical influence of surface states and bulk traps on thin film transistor characteristics : A. Van Calster and H. J. Pauwels. Solid-State Electron.18, 69 (1975)