In order to promote the application of raindrop-shaped flow tube valveless piezoelectric pump (RSFTV PZT pump), basing on the existing research, the RSFTV PZT pump was simulated by computer. Firstly, the existence of the flow resistance of the flow tube was proved by simulation of FLUENT. Then, the dynamic mesh analysis of the pump was carried out to simulate the pumping flow rate at different driving frequencies. Lastly, the simulated results were compared with the experimental results, which shows that the flow rate tendency and value obtained by simulation are basically consistent with that by experiment. The simulation of the RSFTV PZT pump would be helpful to further accelerate related researches and promote the application of RSFTV PZT pump in MEMS and other fields.