Values In Hypertensive Patients Research Articles

Self Management Berhubungan Dengan Nilai Tekanan Darah Pada Pasien Hipertensi

This study aims to determine whether there is a relationship between self-management and blood pressure values ​​in hypertensive patients at UNS Hospital. The method used in this research is a cross sectional approach with a correlational quantitative descriptive research design. The research results were based on the results of the Spearman rank correlation test between self-management and blood pressure values, with a p-value of 0.000 and a correlation coefficient value of 0.363. The results of the research show that there is a correlation between self-management and blood pressure values ​​in hypertensive patients with the level of strength of the relationship between the two variables in the sufficient category. In conclusion, there is a relationship between self-management and blood pressure values ​​in hypertensive patients. Keywords: Self Management, Blood Pressure, Hypertension

The Effect of Pharmacist Counseling on Medication Adherence and Blood Pressure Values in Hypertensive Patients

Hypertension is a disease often found in Indonesia. Hypertension can be controlled by compliance with taking medication and a healthy lifestyle. One effort to increase compliance is counseling. Pharmacist counseling can provide patient education and understanding of hypertension therapy while ensuring that patients are taking medication appropriately so as to increase compliance and control blood pressure. The aim of the research was to determine the effect of pharmacist counseling on drug compliance on blood pressure values in hypertensive patients at the Semarang Community Health Center. This research is a pre-experimental study with a One Group Pretest-Posttest design. Data collection was taken in March-April 2019. Blood pressure results were obtained before and after counseling with a value of p = 0.000 (p 0.05). This research can be concluded that pharmacist counseling can influence medication adherence and systolic and diastolic blood pressure values in hypertensive patients at the Semarang Community Health Center

The Effect of Progressive Muscle Relaxation (PMR) Exercise on Blood Pressure Reduction in Hypertensive Clients: A Literature Review

Compliance with taking antihypertensive drugs is low amongst patients with hypertension. Uncontrolled blood pressure causes heart disease, kidney failure, diabetes, and stroke. It is necessary to have alternative support in controlling blood pressure by using progressive muscle relaxation exercises. This study aimed to determine the effect of progressive muscle relaxation on reducing blood pressure in patients with hypertension. The research design used was a literature study with a sample size of 20 journals: Pubmed (n=2), Proquest (n=4), Science Direct (n=8) and Biomed Central (n=6). By using the keyword search data “Progressive Muscle Relaxation AND Blood Pressure AND Hypertension OR Hypertensive” and using analysis techniques with thematic analysis, 95% of the results of the study reported that there was a decrease in systolic and diastolic values in hypertensive patients before and after the progressive muscle relaxation intervention and 5% reported that there was no change. Progressive muscle relaxation is effective for lowering blood pressure in hypertensive patients.
 Keywords: Progressive Muscle Relaxation, Blood Pressure, Hypertension

SERUM N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVEL IS NEGATIVELY ASSOCIATED WITH VASCULAR REACTIVITY INDEX BY DIGITAL THERMAL MONITORING IN PATIENTS WITH HYPERTENSION

Objective: B-type natriuretic peptide (BNP) participates in the coordination of endothelial regeneration/hypertrophy and the accompanying angiogenesis. Endothelial dysfunction is associated with increased mortality in patients on hypertension. The present study aimed to determine the relationship between serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) level and endothelial dysfunction in patients with hypertension Design and method: The present cross-sectional, single-center study included 90 hypertension patients. An electrochemiluminescence immunoassay was used to measure NT-pro-BNP levels. The endothelial function and vascular reactivity index (VRI) were measured using digital thermal monitoring (DTM) test (VENDYS). In this study, VRI < 1.0 was used as the poor vascular reactivity, 1.0 < VRI < 2.0 was used as the intermediate vascular reactivity, and VRI > 2.0 was used as the good vascular reactivity. Results: Eight hypertensive patients (8.9%) were categorized as poor vascular reactivity (VRI < 1.0), 39 hypertensive patients (43.3%) were categorized as intermediate vascular reactivity (1.0 < VRI < 2.0), and 43 hypertensive patients had good vascular reactivity. Older age (p = 0.012) and higher serum NT-pro-BNP level (p < 0.001) was associated with poor vascular reactivity. Advanced age (r = -0.221, p = 0.036) and logarithmically transformed serum level of NT-pro-BNP (log-NT-pro-BNP, r = -0.505, p < 0.001) was negatively associated with VRI values in hypertensive patients. After multivariable forward stepwise linear regression analysis noted that serum log-NT-pro-BNP level (adjusted R2 change = 0.246, p < 0.001) was significantly and independently associated with VRI values in hypertensive patients. Conclusions: Serum log-NT-pro-BNP levels were negative associated with VRI and associated with endothelial dysfunction in patients with hypertension.

HIGH SERUM TRIMETHYLAMINE N-OXIDE LEVEL IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH HYPERTENSION

Objective: Trimethylamine N-oxide (TMAO) is a metabolite derived from gut microbial metabolism and dietary intake and plays important roles in cardiovascular disease pathogenesis. Endothelial dysfunction is associated with risk factors of cardiovascular disease in patients with hypertension. The present study aimed to determine the correlation between serum TMAO and endothelial function, measured by vascular reactivity index (VRI) in patients with hypertension. Design and method: The present study collected fasting blood samples from 110 patients with hypertension. Serum TMAO levels were determination of by high-performance liquid chromatography–mass spectrometry. The endothelial function and VRI values were measured using digital thermal monitoring test, and VRI values of >2.0, 1.0–1.9 and <1.0 indicated good, intermediate and poor vascular reactivity, respectively. Results: Ten hypertensive patients (9.1%) were categorized as poor vascular reactivity (VRI < 1.0), 57 hypertensive patients (51.8%) were categorized as intermediate vascular reactivity (1.0 < VRI < 2.0), and 43 hypertensive patients had good vascular reactivity. Older age (P = 0.010), higher levels of serum total cholesterol (TCH, P = 0.007), low-density lipoprotein cholesterol (LDL-C, P = 0.009), and TMAO levels (P < 0.001) were associated with poor vascular reactivity. Furthermore, after multivariable forward stepwise linear regression analysis noted that logarithmically transformed serum level of TMAO (log-TMAO, adjusted R2 change = 0.274, P < 0.001) was significantly and independently associated with VRI values in hypertensive patients. Compared with good vascular reactivity index, patients with vascular reactivity dysfunction (intermediate vascular reactivity and poor vascular reactivity; odds ratio (OR) = 1.100; 95% confidence interval (CI) = 1.047–1.155; P < 0.001) or poor vascular reactivity (OR = 1.580, 95% CI = 1.002–2.492, P = 0.049) also noted TMAO was positively associated with poor vascular reactivity after multivariate logistic regression analysis. Conclusions: Serum TMAO levels were negatively associated with VRI and associated with endothelial dysfunction in patients with hypertension.

Effects of concurrent exercise training on blood pressure variability and values are blunted in subjects with non-dipping blood pressure nocturnal pattern

Abstract Funding Acknowledgements Type of funding sources: None. The purpose of this study was to investigate the effects of 12-weeks concurrent aerobic plus resistance exercise training (CT) on short –term blood pressure variability (BPV) and BP values in hypertensive patients with non-dippper BP nocturnal pattern and underlying coronary artery disease. The study included 72 consecutive patients who were divided into two groups according to the nocturnal BP pattern: dipping pattern (33 pts) and non-dipping (39 pts). Before starting CT and at 12 weeks patients underwent six minute walk test, ergometric test, assessment of 1-repetiton mximun (1RM), and 24/h BP monitoring (24-h ABPM). After CT exercise capacity increased in both groups in a similar fashion. Twenty-four/h systolic BPV and daytime systolic BPV decreased significantly in the dipping group while they were unchanged in the nondipping group (between groups changes: -1.0 mmHg and -1.3 mmHg; p 0.02 and p 0.006 respectively). Twenty-four/h systolic BP and daytime systolic BP decreased significantly in the dipping group while were unchanged in the non-dipping group (between groups changes: -7.1 mmHg and -7.8 mmHg; p 0.004 and p 0.0002 respectively). Nighttime systolic BP and BPV was unchanged in both groups. Twenty-four/h diastolic BP presented small not significant changes in both groups. In conclusion: the effects of CT on BPV and BP were blunted in hypertensive subjects with non.dipping BP pattern

Does negative affectivity have an association with achieving target values in hypertensive patients: primary care perspective

ABSTRACT Objectives The current study aimed to seek the relationship between demographic characteristics, treatment compliance status, and type D personality characteristics to achieve target BP values. Methods This cross-sectional research was conducted on HT patients at three family medicine health-care services in Ankara, Turkey, between 1 February 2021, and 31 January 2022. The sociodemographic questionnaire survey, Hill-Bone Compliance to High Blood Pressure Therapy Scale (HBCHBPTS), and Type D Scale-14 (DS-14) were applied to 317 patients. HBCHBPTS consists of 14 items with three domains. DS-14 consists of 14 items assessing negative affectivity (NA) and social inhibition (SI). Results Patients with NA were less likely to achieve the SBP target values (62.20% vs 47.50, p = 0.011). NA scores were correlated with HBCHBPTS total scores and HBCHBPTS medication-taking domain scores. Living in a city center (β = −0.157, p = 0.017), not smoking (β = −0.114, p = 0.042), knowing the names of HT drugs (β = - 0.152, p = 0.005), having a Mediterranean-style diet (β = −0.182, p = 0.002), starting treatment immediately after diagnosis (β = −0.121, p = 0.029), older age (β = −0.164, p = 0.028), having less NA scores (β = 0.171, p = 0.029) were effective on better treatment adherence. Variables affecting the failure to achieve the SBP target values were not being in the extended family (p = 0.022, OR: 0.337), anti-HT drug side effects (p = 0.029, OR: 2.566), higher HBCHBPTS total scores (p = 0.001, OR: 1.178), higher DBP values (p < 0.001, OR: 1.141). Conclusion HBCHBPTS total and HBCHBPTS medication-taking domain indicators worsened as the NA and SI characteristics increased. Predictors, including those not living in an extended family, being affected by the side effects of anti-HT drugs, high HBCHBPTS total score, and high DBP values, were effective in failure to achieve the SBP target values.

Study on the use of multi-compartment compliance aids to improve blood pressure values in hypertensive patients

To analyse the improvement of adherence in non-adherent patients with uncontrolled HT, polymedicated and older than 55 years after the use, or not, of Multicompartment compliance aids (MCA). Longitudinal research (6 month). Levels of adherence to treatment were analysed using an adapted version of Morisky-Green test, counting of returned medication (MCA group) and blood pressure (BP) values. Site: Multicentre study in 35 community pharmacies in Spain. Participants: 195 participants (88 MCA group and 107 control group) older than 55 years, polymedicated, non-adherent to medication, with uncontrolled hypertension and using electronic prescription. Interventions: MCA group received their medication in MCA while control group received their medication as usual. Main measurements: Systolic BP/Diastolic BP was recurrently measured with a digital tensiometer in both groups. MCA group obtained a significant decrease in BP values compared to the control group (Systolic BP decreased by 18.3 mmHg in the MCA group vs. 9.9 mmHg in the control group and Diastolic BP by 9.9 mmHg vs. 8.9 mmHg). Both groups increased their adherence to over 90%. The use of MCA controlled BP levels in almost 50% of the participants. For this fact, MCA is postulated as a good tool (cost-effective, well tolerated by users, easy to use ...) to improve the adherence of patients and control their hypertension, although more studies are necessary.

Efekat metaboličkog sindroma na incidencu i stepen hipertrofije miokarda leve komore kod hipertenzivnih pacijenata

Metabolic syndrome (MetS) is characterized by the simultaneous presence of obesity, hypertension, dyslipidemia and hyperglycemia in an individual, which leads to an increased risk of cardiovascular disease (CVD). Left ventricular hypertrophy (LVH) is thickening of the heart muscle wall -hypertrophy of cardiomyocytes in concentric and/or elongation of cardiomyocytes and hyperplasia of connective tissue in eccentric hypertrophy with the participation of hemodynamic and non-hemodynamic factors (genetics, stress, other external factors). MetS, which essentially includesinsulin resistance, hyperinsulinemia, and hyperglycemia, alters myocardial metabolism and promotes myocardial inflammation, fibrosis, hypertrophy, and left ventricular remodeling. OBJECTIVE: To determine the impact of MetS, that is, obesity to the incidence and degree of severity of LVH in hypertensive patients with metabolic syndrome in comparison with the control group -hypertensive patients without metabolic syndrome. PATIENTS AND METHODS: Consecutive patients of the Office of Internal Medicine "Dr. Bastać" were examined, a total of 55 patients with hypertension, who were divided into two groups: the first group with MetS, 22 people, average age 56±8.5 years with BMI&gt;30kg /m 2 and waist circumference more than 80 cm for women and &gt;94 cm for men, the second control group without MetS-33 people, average age 52±14 years, with BMI&lt;30kg/m 2 . Echocardiography was done for all subjects on a Power Vision 6000 Toshiba echo camera with standard echocardiographic measurements in the M, B and Doppler technique, and the mass of the left ventricular myocardium was determined for them using the Devereux formula. RESULTS: The prevalence of LVH in group 1 with metabolic syndrome (MetS) was 64%, while in the control group without (MetS) it was 36%. There was a statistically significantly higher number of patients with LVH in hypertension with MetS compared to hypertensive patients of the control group without MetS (X2, p=0.027). In the group of hypertensive patients with MetS, the degree of severity of myocardial hypertrophy, that is, the myocardial mass , was statistically significantly higher compared to the control group (respectively 302±84g versus 224±89g, p=0.0002). Arterial pressure values were higher for both systolic and diastolic blood pressure 168/106 mmHg in hypertensive patients with MetS, but did not reach statistical significance in relation to blood pressure values in hypertensive patients without MetS (156/95 mmHg, p=0.16). CONCLUSION. Patients with metabolic syndrome and hypertension have a statistically significantly higher prevalence of left ventricular myocardial hypertrophy and a highly statistically significant degree of left ventricular hypertrophy compared to the control group of hypertensive individuals without MetS. Given that mean values of arterial pressure do not differ between groups, it can be concluded that non-hemodynamic factors for the development of LVH have an important role in the induction of a more severe degree of LVH in hypertensive patients with metabolic syndrome.

887 THE EFFECTS OF CONCURRENT AEROBIC PLUS RESISTANCE EXERCISE ON BLOOD PRESSURE VALUES AND VARIABILITY AND ARE BLUNTED IN HYPERTENSIVE SUBJECTS WITH NONDIPPING NOCTURNAL BLOOD PRESSURE PROFILE

Abstract Background The purpose of this study was to investigate the effects of 12-weeks of concurrent aerobic plus resistance exercise training (CT) on short –term blood pressure variability (BPV) and BP values in hypertensive patients with nondippper BP nocturnal pattern and underlying coronary artery disease. Methods The study included 64 patients who were divided into two groups according to the nocturnal BP pattern: dipping pattern (29 pts) and nondipping (35 pts). Before starting CT and at 12 weeks patients underwent ergometric test, assessment of 1-repetiton mximun (1RM), and 24/h BP monitoring (24-h ABPM). Results after CT Twenty-four/h systolic BPV and daytime systolic BPV decreased significantly in the dipping group (-1.2 mmHg and -1.4 mmHg respectively) while they were unchanged in the nondipping group (-0.2 mmHg and -0.1 mmHg). Twenty-four/h systolic BP and daytime systolic BP decreased significantly in the dipping group (-8.3 mmHg and -8.5 mmHg respectively) while were unchanged in the nondipping group (-1.2 mmHg and -0.7 mmHg). Nighttime systolic BP and BPV was unchanged in both groups. Conclusion the effects of CT on BP and BPV are blunted in hypertensive subjects with nondipping BP pattern. Further studies are needed in order to find out more effectives training modalities for these patients

Concurrent Aerobic Plus Resistance Training Elicits Different Effects on Short-Term Blood Pressure Variability of Hypertensive Patients in Relation to Their Nocturnal Blood Pressure Pattern.

Background and Objectives: The purpose of this study was to investigate the effects of a 12-week concurrent training (CT) (i.e., aerobic plus resistance exercise) on short-term blood pressure variability (BPV) and BP values in hypertensive patients with non-dippper BP nocturnal pattern and underlying coronary artery disease. Material and Methods: The study included 72 consecutive patients who were divided into two groups according to the nocturnal BP pattern: dipping pattern (33 pts) and non-dipping (39 pts). Before starting CT and at 12 weeks, patients underwent the six minute walk test, ergometric test, assessment of 1-repetiton maximum (1 RM), and 24/h BP monitoring (24-h ABPM). Results: After CT, exercise capacity increased in both groups in a similar fashion. Twenty-four/h systolic BPV and daytime systolic BPV decreased significantly in the dipping group while they were unchanged in the non-dipping group (between groups changes: -1.0 ± 0.4 mmHg and -1.3 ± 0.9 mmHg; p = 0.02 and p = 0.006, respectively). Twenty-four/h systolic BP and daytime systolic BP decreased significantly in the dipping group while they were unchanged in the non-dipping group (between groups changes: -7.1 ± 2.6 mmHg and -7.8 ± 2.4 mmHg; p = 0.004 and p = 0.002, respectively). Nighttime systolic BP and BPV was unchanged in both groups. Twenty-four/h diastolic BP presented small but not significant changes in both groups. Conclusions: The effects of CT on BPV and BP were blunted in hypertensive subjects with a non-dipping BP pattern.

The impact of low-salt bread as a simple diet on hypertensive patients with cardiovascular comorbidities.

During recent years, hypertension and related cardiovascular complications have become the leading health challenges of this century. Non-pharmacologic strategies, emphasizing mainly salt restriction and physical activity, are recommended for all patients with hypertension. Our objective was to assess the impact of low salt white bread intake, widely consumed in Western Algeria, on blood pressure values in hypertensive patients with and without comorbidities. 134 hypertensive patients (male = 78, female = 56) were included. The study population was divided into two groups according to their choice of following a low salt white bread diet or not. Their dietary salt intake and physical activity were surveyed along with their blood pressure measurements and associated comorbidities. Other clinical and anthropometric data were collected. Patients following low salt bread diet showed decreased systolic and diastolic blood pressure values (119.07/74.63 mmHg) compared to the second group (131.92/79.81) (p < 0.01). These results were observed specifically in patients with adjacent cardiovascular diseases who seem to be less compliant to the diet (41.1% of the whole population, p < 0.05) and show significant increased blood pressure (135.75/81.53 mmHg) compared to compliant patients (116.66/75.33 mmHg) (p < 0.01). The study highlights the impact of low salt bread diet on the treatment of hypertension with and without comorbidities.

Reduce Blood Pressure Values Of Hypertension Patients Using Slow Deep Breathing

This study aimed to determine the effect of slow deep breathing techniques onblood pressure values in hypertensive patients. This research is a PreExperimental Design with One Group Pretest-Posttest. The sampling technique used is non-probability sampling, purposive sampling with a research sample of22 respondents. Univariate results obtained an average respondent of 60 years, with the majority gender 21 respondents (95.4%). Bivariate results showed that the p-value of the statistical test using the Wilcoxon test was known that the p-value was 0.000 (&lt;0.05). In conclusion, slow deep breathing techniques affect blood pressure values in hypertensive patients at Puskesmas 23 Ilir Palembang in 2022

P.0678 Tensional values in hypertensive patients treated with intranasal esketamine for resistant depression

P.0678 Tensional values in hypertensive patients treated with intranasal esketamine for resistant depression

STATIN THERAPY IS ASSOCIATED WITH BETTER 24-HOUR AND NIGHT-TIME BLOOD PRESSURE CONTROL IN HYPERTENSIVE PATIENTS

Objective: Hypertension and dyslipidemia often coexist. Statin therapy was associated with lower blood pressure (BP) in some but not all studies. Aim: to evaluate the association between statin therapy and 24-hour BP in a large hypertensive population, using propensity score matching analysis. Design and method: Retrospective study on 1827 consecutive essential hypertensives evaluated with 24 h ambulatory BP monitoring. Anti-hypertensive treatment intensity (ATI) was calculated to compare different drug associations. We used a propensity score matching to compare two equally-sized cohorts of patients (369 patients in each group) with similar characteristics according to statin therapy (age, sex, body mass index, smoking habit, diabetes mellitus, total cholesterol, high-density lipoprotein cholesterol, triglycerides, low-density lipoprotein cholesterol, estimated glomerular filtration rate, glycaemia, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, calcium channel blocker, diuretic, mineralocorticoid receptor antagonist, beta-blocker, alfa-blocker, ATI, 24 h pulse pressure). Matching was performed on log-transformed propensity score in a 1:1 fashion with a caliper of 0.1, in order to account for the different baseline characteristics between statins and non-statins groups. Results: Mean age: 58.1 ± 13.8 years; male sex: 55%. Patients on statin therapy: 402 (22%). The different statins were taken as follows: atorvastatin (39.8%), simvastatin (35.8%), rosuvastatin (15.7%), pravastatin (5.6%), lovastatin (2.3%) and fluvastatin (0.8%). Patients on statins showed lower 24 h BP (-2.8/-7.1 mmHg), daytime (-3.3/-7.6 mmHg) and night-time BP (-2.5/-6.0 mmHg, all p &lt; 0.001). They also showed better ambulatory BP control, even after adjustment for confounders. The analyses on the groups derived from the propensity score matching (369 patients in each group) confirmed these results (OR 1.8 for 24 h BP control; OR = 1.6 for daytime BP control; OR = 1.7 for night-time BP control, all p &lt; 0.001). Conclusions: Conclusions: Statin therapy is associated with lower ABPM values in hypertensive patients. This result is not affected by the anti-hypertensive treatment intensity or by the several cofactors analyzed, but may depend on greater adherence to prescribed drug therapies as suggested by the assumption of a nocebo-tainted drug class. The cardiovascular benefit of statins is due to the reduction of blood cholesterol and effects on blood pressure may be just indirect.

Assessment of sudomotor function in hypertensive with/without type-2 diabetes patients using SUDOSCAN: An electrophysiological study

ObjectiveElectrochemical skin conductance (ESC) test is a simple and non-invasive screening test can detect dysfunction of the peripheral sudomotor, and indirectly estimates the function of cardiac autonomic nerves. This study aimed to assess the ESC values in hypertensive patients with/without type-2 diabetes by using SUDOSCAN technology. Moreover, this study evaluated the role of cardiometabolic risk factors on the results of ESC test. MethodsThis cross-sectional study was carried on three groups of participants, includinghealthy subjects (Group I, n = 49), hypertensive without type-2 diabetes (Group II, n = 75) patients, and hypertensive with type-2 diabetes (Group III, n = 76) patients. Body mass index (BMI), blood pressure (systolic, diastolic and pulse pressure index), fasting serum glucose, and lipid profile were determined. ESC test as a measurement sudomotor function was determined by applying a small direct current at low voltage to hands and feet sensor plates through SUDOSCAN device. ResultsESC values of the peripheral sudomotor nerves in the Group II and III patients were significantly lower than the corresponding values of Group I. SUDOSCAN results of Group II and III. Significant discriminators of cardiac autonomic neuropathy (≥30 score) that determined by the area under the curve (AUC) with 95% confidence interval (95% C.I.) were, duration of the disease, BMI, and mean blood pressure in Group II, while the duration of the disease and the BMI were significant discriminators in Group III. ConclusionsSUDOSCAN is a simple, useful device, which can detect the impairment of peripheral autonomic small nerve fibers and the risk of cardiac autonomic neuropathy in hypertension. Moreover, the duration of the disease and the associated cardiometabolic risk factors are important predictors of significant SUDOSCAN findings. SignificanceESC test is useful in detecting subclinical neuropathy in hypertensive patients as well as in type 2 diabetes.

Intrarenal renin-angiotensin system in hypertensive patients with localized kidney cancer.

e17069 Background: In the last decade, the relationship between arterial hypertension and the risk of developing kidney cancer has been pointed out. Some studies have shown that the metabolic imbalance of the components of the renal renin-angiotensin system (RAS) is associated with the development and progression of kidney cancer. Aim: To study the state of RAS in tumor and peritumoral tissues in hypertensive patients with kidney cancer. Methods: In patients with localized kidney cancer T1N0M0 and grade I-II arterial hypertension without special treatment (n = 40; KC + AH) in the samples of tumor (TT), peritumoral (PTT) and histologically unchanged tissue (HUT), the levels of angiotensin 1 and 2, 1-7 (AT1 and AT2, AT (1-7)) of angiotensin-converting enzymes (ACE and ACE2) were determined by ELISA. The comparison group consisted of patients with RC without impaired blood pressure (n = 55, KC). Results: In patients with KC, the level of AT1 is 1.5 times higher (p &lt; 0.05), and AT2 is 1.6 times higher (p &lt; 0.05) in TT against the background of unchanged content in PTT compared with HUT. The level of ACE is higher than HUT by 2.7 times, ACE2 - by 1.6 times (in all cases p &lt; 0.05), and in PTT it is identical in HUT. In patients with KC + AH, the level of AT1 and AT2 in the TT is 1.8 times higher (p &lt; 0.05) and 2.1 times (p &lt; 0.01), respectively, the content of AT(1-7) is 1.6 times (p &lt; 0.01). In PTT, AT1 is 1.6 times higher (p &lt; 0.01) and AT2 is 1.9 times higher (p &lt; 0.05), significantly lower than only AT2 in the TT (1.2 times at p &lt; 0, 05). The level of AT(1-7) in the PTT is identical to the values in the GNT. The content of ACE and ACE2 in TT is 3.6 and 2.9 times higher, respectively, and in PTT is identical to that in TT. Correlation analysis revealed a reliable direct relationship in the studied groups for all parameters, while in the PTT of hypertensive patients, the relationship between the average blood pressure and the RAS peptide content had a higher tightness. Conclusions: An increase in the levels of angiotensin 1 and 2, angiotensin-converting enzymes ACE and ACE2 in the tumor tissues and peritumoral tissue in patients with localized kidney cancer, regardless of the presence of arterial hypertension at initially higher values in hypertensive patients, was shown. The presence of arterial hypertension in patients with KC changes the metabolism of local RAS in peritumoral tissue and is associated with an increase in the correlation between changes in the components of RAS and arterial hypertension.

Tissue synthesis of some components of the renin-angiotensin system in hypertensive patients with localized kidney cancer

Background. In the last decade, the relationship between arterial hypertension and the risk of developing kidney cancer (KC) has been pointed out. Some studies have shown that the metabolic imbalance of the components of the renal renin-angiotensin system (RAS) is associated with the development and progression of KC.Objective: to study the state of RAS in tumor and peritumoral tissues in patients with KC on the background of arterial hypertension. Materials and methods. In patients with localized KC T1N0M0 and grade I–II arterial hypertension without special treatment (n = 40) in the samples of tumor, peritumoral and histologically unchanged tissue, the levels of angiotensins 1, 2, 1–7 (AT1, AT2, AT(1–7)) of angiotensin-converting enzymes (ACE, ACE2) were determined by ELISA. The comparison group consisted of patients with RC without impaired blood pressure (n = 55).Results. In patients with KC, the level of AT1 is 1.5 times higher (p &lt;0.05), and AT2 is 1.6 times higher (p &lt;0.05) in tumor tissue against the background of unchanged content in peritumoral tissue compared with histologically unchanged tissue. The level of ACE is higher than histologically unchanged tissue by 2.7 times, ACE2 – by 1.6 times (in all cases p &lt;0.05), and in peritumoral tissue it is identical in histologically unchanged tissue.In patients with KC and arterial hypertension, the level of AT1 and AT2 in the tumor tissue is 1.8 times higher (p &lt;0.05) and 2.1 times (p &lt;0.01), respectively, the content of AT(1–7) is 1.6 times (p &lt;0.01). In peritumoral tissue, AT1 is 1.6 times higher (p &lt;0.01) and AT2 is 1.9 times higher (p &lt;0.05). The level of AT(1–7) in the peritumoral tissue is identical to the values in the histologically unchanged tissue. The content of ACE and ACE2 in tumor tissue is 3.6 and 2.9 times higher, respectively, and in peritumoral tissue is identical to that in tumor tissue. Correlation analysis revealed a reliable direct relationship in the studied groups for all parameters, while in the peritumoral tissue of hypertensive patients, the relationship between the average blood pressure and the RAS peptide and enzymes content had a higher tightness.Conclusion. An increase in the levels of AT1 and AT2, ACE and ACE2 in the tumor tissues and peritumoral tissue in patients with localized KC, regardless of the presence of arterial hypertension at initially higher values in hypertensive patients, was shown. The presence of arterial hypertension in patients with KC changes the metabolism of local RAS in peritumoral tissue and is associated with an increase in the correlation between changes in the components of RAS and arterial hypertension.

P286 Inverse relation between systolic blood pressure variability and global longitudinal strain in patients with Parkinson"s disease and autonomic dysfunction

Abstract Background Parkinson"s disease (PD) patients often present cardiac blood pressure (BP) derangement as a result of autonomic dysfunction. However their echocardiography pattern have been poorly investigated yet . Study aim: to evaluate the correlation between indices of left ventricular function ad 24/h blood pressure pattern in patients with PD Methods We evaluated 20 patients with diagnosed PD and autonomic dysfunction and 15 hypertensive age-matched subjects. All patients performed 24/h blood pressure monitoring (ABPM) and echocardiography. Left ventricular systolic function was evaluated through ejection fraction (EF), tissue doppler S wave and global longitudinal strain (GLS). BP variability (BPV) was evaluated through average real variability. Results GLS (17.6 vs 22.8; p = 0.04) was reduced in the PD group compared to hypertensive patients. Conversely EF and S wave was similar between the two groups. Patients with PD had an inverse significant correlation between GLS and 24/h systolic BPV (r= -0.64; p = 0.003) and a trend through significance between S wave and systolic BPV (r= -0.31; p = 0.07). sNocturnal diastolic BP was inversely related to GLS (r= -0.44; p = 0.001) . There were no correlation between GLS and BPV and values in hypertensive patients. Conclusions In PD patients GLS is related to indices of poor BP control. GLS appears to be an early detector of LV dysfunction in patients with PD and autonomic dysfunction.

Effect of lifestyle on blood pressure in Portuguese population under antihypertensive drugs

Abstract Background Hypertension is one of the main risk factors for disability and death from cardiovascular diseases. Current guidelines include initiatives to control blood pressure values in hypertensive patients that focus on lifestyle changes. The main objective of this study was to estimate the association between lifestyle and blood pressure in patients under antihypertensive drugs. Methods An analysis of the data of Portuguese Health Examination Survey (INSEF) was performed. Individuals who met INSEF inclusion criteria and who referred to be under antihypertensive drugs in the two weeks prior to the questionnaire were studied. Lifestyle variables (alcohol consumption, smoking, additional salt intake, fruit and vegetables consumption, practice of physical activity) were measured by questionnaire, and blood pressure values were obtained by physical examination. Associations between lifestyle factors and blood pressure, stratified by sex and adjusted to sociodemographic variables and to obesity, were estimated through a multiple linear regression model. Results Alcohol consumption (ß=6.31, p = 0.007) and smoking (ß=4.72, p = 0.018) were associated with systolic blood pressure in men. Additional salt intake, fruit and vegetable consumption, and practice of physical activity were not associated with blood pressure in men. In women, no association was observed for any behavioural variable. Conclusions These conclusions reinforce the need, also in the population under antihypertensive drugs, particularly in the male sex, to focus the fight against high systolic blood pressure in these two modifiable and preventable behaviours: smoking and alcoholic consumption. Key messages Alcohol consumption and smoking are the behavioral determinants associated with high systolic blood pressure values in men under antihypertensive drugs. These conclusions reinforce the need to focus the fight against high systolic blood pressure in the preventable and modifiable behavioural determinants.