Values In Female Rats Research Articles

The effect of sex on the uptake of very low density lipoprotein triglyceride fatty acid from the plasma of the rat in vivo

Radioactive very low density lipoprotein (VLDL) was prepared by perfusion in vitro of livers isolated from normal fed male and female rats with [1- 14C] oleate or [9, 10- 3H] oleate, respectively. These VLDL, whose properties differed due to sex, were mixed. Aliquots of the mixture were injected intravenously into fasted male and female rats and the decay of the radioactivity ( 14C and 3H) was measured. Disappearance of radioactivity from plasma triglyceride was more rapid in female animals. Plasma half-life of 14C and 3H was 42.5±3.7 and 49.7±4.4 minutes, respectively, when the VLDL mixture was injected into male rats. The corresponding values in female rats were 28.3±1.1 and 30.7±1.7, respectively. These data suggest strongly that the rate of utilization of VLDL triglyceride fatty acid is more rapid in the female than in the male, and that the properties of the VLDL particles are of less importance than innate sex differences in the recipient for the rate of clearance of triglyceride fatty acids.

Toxicity of sodium pentafluorostannite, a new anticariogenic agent. I. Comparison of the acute toxicity of sodium pentafluorostannite, sodium fluoride, and stannous chloride in mice and/or rats

The toxicity of sodium pentafluorostannite (NaSn 2F 5) in mice and rats has been investigated. LD50 values in mice were 18.9, 80.9, and 592.9 mg/kg in fed mice dosed iv, ip, and po, respectively. Signs of toxicity in mice included ataxia, muscle weakness, central nervous system depression, and occasionally tremors. LD50 values in female rats were 12.9, 65.0, and 218.7 mg/kg in fed rats dosed iv and ip and in fasted rats dosed po, respectively. LD50 values in male rats were 12.9, 75.4, 573.1, and 223.1 mg/kg in fed rats dosed iv, ip, and po and in fasted rats dosed po, respectively. Signs, accompanying toxic doses of NaSn 2F 5, sodium fluoride (NaF), or stannous chloride (SnCl 2·2H 2O) in the rat were similar and included ataxia, muscle weakness, and CNS depression. Sodium pentafluorostannite was found to be more toxic than either NaF, based on F, or SnCl 2·2H 2O, based on Sn. Rats given either Sn compound developed pathologic changes in the kidneys grossly visible 4 days following administration. The data suggest that both F and Sn play a role in the acute toxicity of NaSn 2F 5 in rats.