Protective Value Research Articles

How to balance respect for diversity and the rights of the vulnerable? (Non-)recognition of forced and underage marriage under the lens of the European Convention on Human Rights

Partly in view of the migratory phenomenon to which Europe is exposed, forced and underage marriages nowadays deserve careful consideration both as social phenomena and as legal institutions. This paper aims to verify whether and to what extent forced and underage marriages should be recognised in Europe. On the one hand, recognising the validity of these acts could arguably clash with fundamental values and rights protected by the European Convention on Human Rights and the Convention on Preventing and Combating Violence against Women and Domestic Violence. On the other hand, it is not possible to a priori exclude that a flat refusal to recognise a marriage validly established abroad might entail a violation of further rights of the spouses and ultimately have detrimental consequences for the parties that the refusal aims to protect. The aim is to assess whether private international law tools and techniques can offer a proper balance between respect for the fundamental values of reception societies and protection of the rights and interests of the parties involved.

Electrically Insulative Film Adhesive with Enhanced Thermal Performance to Assemble High Power Density Electronic Devices

Assembly adhesives play a critical role in microelectronic packaging and contribute significant value for circuit assembly interconnection, protection, and thermal management. Of particular interest with today’s more powerful systems is thermal management of high-power density electronic systems, including power modules, power amplifiers, communication systems, and directed energy systems. As requirements for performance and functionality increase, heat generated from these devices increases exponentially. For example, local heat flux can easily exceed 50 W/cm2 for IGBT power modules while it may reach several hundred Watts/cm2 at active areas for Gallium Nitride (GaN) power amplifiers. Simultaneously, many of these systems demand a higher level of electrical insulation to eliminate or minimize current leakage to ensure high reliability over a long service life. Effectively and safely dissipating the high heat and ensuring excellent electrical insulation has become an increasingly critical and challenging task in the microelectronics packaging technology for aerospace and defense systems. This paper presents integration of thermally conductive adhesives with an electrically insulative polyimide film into a carefully engineered laminate, which enables high thermal transfer and robust electrical insulation. This new film adhesive provides outstanding compliance and augmented tolerance to large topographical features and warpage (5-7 mils). This film adhesive is one of the potential solutions to addresses the evolving needs of the electronics assembly industry in the areas of management of high-power systems

Selective leaching process for efficient and rapid recycling of spent lithium iron phosphate batteries.

With the continuous development of new energy vehicles, the number of decommissioned lithium iron phosphate (LiFePO4) batteries has been constantly increasing. Therefore, it is necessary to recover metal from spent LiFePO4 batteries due to the high potential for environmental protection and high resource value. In this study, sodium persulfate (Na2S2O8) was selected as the oxidant to regulate and control the oxidation state and proton activity of the leaching solution through its high oxidizing ability. Selective recovery of lithium from LiFePO4 batteries was achieved by oxidizing LiFePO4 to iron phosphate (FePO4) during the leaching process. This paper reports an extensive investigation of the effects of various factors, including the acid concentration, initial volume fraction of the oxidant, reaction temperature, solid-liquid ratio, and reaction time, on lithium leaching. Li+ reached a high leaching rate of 93.3% within 5 minutes even at a low concentration of sulphuric acid (H2SO4), and high-purity lithium carbonate (Li2CO3) was obtained through impurity removal and precipitation reactions. In addition, the leaching mechanism was analysed by both X-ray diffraction and X-ray photoelectron spectroscopy characterization. The results show that the obtained high lithium-ion (Li+) leaching efficiency and fast Li+ leaching time can be ascribed to the superior oxidizing properties of Na2S2O8 and the stability of the crystal structure of LiFePO4 during the oxidative leaching process. The adopted method has significant advantages in terms of safety, efficiency and environmental protection, which are conducive to the sustainable development of lithium batteries.

How Well Do Religious Exemptions Apply to Mandates for COVID-19 Vaccines?

In the United States, religious exemptions to health-driven mandates enjoy, and should enjoy, protected status in medical ethics and healthcare law. Religious exemptions are defined as seriously professed exceptions to state or federal laws, which appeal to Title VII of the Civil Rights Act of 1964, allowing workers to request an exception to a job requirement, including a health-protective mandate, if it “conflicts with their sincerely held religious beliefs, practices, or observances”. In medical ethics, such religious exceptions are usually justified on the basis of the principle of autonomy, where personally held convictions, reflected in scripture or established religious norms, are safeguarded on the basis of the first amendment, thereby constituting an important area in which societal good must yield to individual liberty. Acknowledging the longstanding category of “religious exemptions”, and referencing some examples that adhere to its parameters in good faith (e.g., objections made by some institutions to HPV vaccines), I argue that, to date, no coherent basis for religious exemptions to COVID-19 vaccines has been offered through appeal to the principle of autonomy, or, in a healthcare context, to “medical freedom”. Indeed, proponents of characterizing these exemptions as legitimate misconstrue autonomy and abuse the reputation of the religious traditions they invoke in defense of their endeavors to opt out. The upshot is not only an error in interpreting the principle of autonomy, whereby it is issued a “blank check”, but also a dishonesty in itself whereby a contested political position becomes deliberately disguised as a protected religious value. “Sincerely held beliefs”, I conclude, appear no longer to constitute the standard for religious accommodation in the era of COVID-19. Individual declaration, seemingly free of any reasonable constraint, does. This is a shift that has serious consequences for public health and, more broadly, the public good.

Polymorphism of vascular homeostasis genes as a risk factor for the formation of preeclampsia

Introduction. Preeclampsia (PE) is a serious complication of pregnancy that occurs in 3-8% of pregnant women and is the leading cause of maternal and perinatal morbidity and mortality.Aim. To evaluate the role of vascular homeostasis gene polymorphism in the formation of preeclampsia.Materials and methods. The sample for this study included 250 women with preeclampsia and 209 women with normal gestation (control group). Five polymorphic loci of vascular homeostasis genes were selected for analysis: α-adducin (G460W ADD1), β2-adrenoceptor (+46G/A ADRB2), endothelin-1 (Lys198Asn EDN1) encoding the β3 G protein subunit (G/A GNB3), cytochrome 3A5 (+6986G/A CYP3A5). The molecular genetic study of all SNPs was carried out by polymerase chain reaction.Results. It was found that genetic variants determine the risk of developing preeclampsia. The allelic variant 198Lys EDN1 (84.80%) occurs in women with a clinical diagnosis of PE significantly more often than in women of the control group (79.67%) (p = 0.05; OR = 1.43; 95%CI 1.01–2.03). At the same time, among pregnant women without PE, combinations of 198Asn EDN1 x +46 A ADRB2 (23.65%) and 198Asn EDN1 x 460 ADD1 x +46 A ADRB2 (23.65%) are registered 1.6–1.7 times more often than among women with PE (14.46 and 13.65%, respectively, рperm = 0.032). Conclusion. The risk factor for the formation of preeclampsia is the 198Lys EDN1 allele (OR = 1.43), and combinations of genetic variants 198Asn EDN1 х +46 A ADRB2 (OR = 0.55) and 198Asn EDN1 х +46 A ADRB2 х 460G ADD1 (OR = 0.51) have a protective value.

Environmental Requirements for Passenger Terminal Development (Case Study of Zadar County)

Cruising as part of nautical tourism is an important segment of maritime passenger transportation. Nautical tourism and cruise tourism have developed over the years and are experiencing increasing demand, with the exception of the pandemic period, when cruise tourism did not experience positive trends. In normal tourism conditions, high growth requires an increase in supply, which can have negative consequences for the environment. This is especially true when the destination where cruise tourism is developing has a fragile ecosystem. At a time when environmental sustainability and responsibility are becoming increasingly important, tourism supply is implementing the parameters of sustainability in its development, and cruise tourism is no exception. However, the fact is that the development of passenger terminals inevitably changes the view of the coast. The aim of this paper is to thoroughly define the parameters whose reconstruction is necessary for the construction of a passenger terminal and for which it is necessary to analyze the impact on the environment in order to make the construction itself environmentally friendly. Systematic analysis is the most appropriate method for delineating the parameters whose reconstruction could harm the environment and have negative effects on the sustainability of the ecosystem as well as on tourism and locals in the area. The results of the analysis conducted on the example of capacity construction in the coastal region of Zadar County show that special consideration must be given to protected natural values, landscape properties, population, purpose and use of space, noise and air. It can be concluded that disregarding all the construction parameters described in the study and emphasizing the financial benefits could affect the ecosystem in the long run. Besides the analyses, the proposal for the environmental monitoring program was elaborated on in this paper.

Protective indigenous collective value of Ubuntu and child neglect: Implications for rural child protection practice

AbstractTheories on collective efficacy and social support suggest that indigenous values that support collective practices and sanction community obligations to childcare would be protective against child neglect. Likewise, new qualitative findings show that collective values are stronger in rural areas than in urban. This study tested the claims that the value of Ubuntu, which is a symbolic cultural value of ‘being for others’, will be protective against the likelihood of neglect; this relationship will be stronger in rural compared with urban communities in Ghana. Using data obtained from a nationally representative sample of 1100 mothers (from 22 communities) in Ghana, we tested the claims using fixed effects logistic regression. The Ubuntu norms were significantly endorsed in rural communities compared with the urban. The overall model showed that higher levels of Ubuntu are associated with lower odds of child neglect (OR .47, [.29, .76] p < 0.05), and the relationship remained significant only in the rural sample (OR .13, [.06, .31] p < 0.001). Similar evidence was recorded for the Ubuntu norms of community care and compassion. The results suggest that child protection in rural Ghana can be fruitful when interventions are developed to boost the value of Ubuntu and the norms of collective childcare.

Where and why is landscape considered valuable? Societal actors’ perceptions of ecosystem services across Bavaria (Germany)

ABSTRACT Balancing the demand for ecosystem services (ES) with available supply is one key challenge for decision making in sustainable landscape management. ES demand is context-specific. Therefore, the assessment of perceptions articulated by multiple societal actors in different regions can help to identify differences and commonalities in predominant preferences for landscapes and their ES. The goal of this study was to investigate four societal actor groups (citizens, farmers, foresters, nature managers) in 12 study regions across Bavaria, Germany, with respect to their valuation of landscapes and ES provided by certain landscape elements. The 2,438 participants mapped specific locations and selected landscape elements that they perceived as valuable, and further elaborated on this value in open statements. We applied qualitative content analysis, word frequency analysis, spatial location-density analysis, and statistical testing. The perceived value of landscape elements for ES differed across actor groups and regions. Preference for landscape elements was driven by topography and land use and was significantly associated with actor groups. The most apparent differences occurred between farmers and nature managers. Generally, participants preferred forests, water bodies, natural landscapes, and distinct geographical structures. The landscape was mostly valued for its habitat, diverse wildlife, recreational purposes, climate-regulating functions, and provisioning of water and food. We conclude that, although differences exist among societal actors, the study respondents highly valued the importance of functioning and diverse ecosystems. The high perceived value for many ecosystem services and species protection suggests that ambitious policy measures are supported by different societal actors.

Observation of strong backscattering in valley-Hall photonic topological interface modes

The unique properties of light underpin the visions of photonic quantum technologies, optical interconnects and a wide range of novel sensors, but a key limiting factor today is losses due to either absorption or backscattering on defects. Recent developments in topological photonics have fostered the vision of backscattering-protected waveguides made from topological interface modes, but, surprisingly, measurements of their propagation losses were so far missing. Here we report on measurements of losses in the slow-light regime of valley-Hall topological waveguides and find no indications of topological protection against backscattering on ubiquitous structural defects. We image the light scattered out from the topological waveguides and find that the propagation losses are due to Anderson localization. The only photonic topological waveguides proposed for materials without intrinsic absorption in the optical domain are quantum spin-Hall and valley-Hall interface states, but the former exhibit strong out-of-plane losses, and our work, therefore, raises fundamental questions about the real-world value of topological protection in reciprocal photonics.

Tradisi “Sedekah Bumi” dalam Prespektif Perlindungan dan Pengelolaan Lingkungan Hidup

This study aims to determine the meaning of the almsgiving earth tradition in people's lives and the correlation of the meanings of the almsround earth tradition in the perspective of the value of environmental protection and management. This research method uses normative legal research with a statutory and conceptual approach. As for the results of the research that the almsgiving earth tradition in people's lives in principle has values including the values ​​of hablum minallah, hablum minannas and hablumminal alam, while the meaning of the alms earth tradition has a correlation with the values ​​or principles of environmental protection and management, namely with some values ​​or principles include; the value of sustainability and sustainability, the value of harmony and balance, the value of integration, the value of utilization, the value of prudence, the value of justice, the value of participatory and the value of local wisdom, from this correlation it is hoped that the values of almsgiving can encourage the birth of habits from human awareness as khalifatul fil ardhi to position the environment as a subject that has fundamental rights (human rights as nature/environment) as well as human positions to be protected so that in the end between the environment and humans protect and love one another.

Exploring the effects of various rotation lengths on the ecosystem services within a multiple-use management framework

Addressing the spatio-temporal dynamics of forest development under different management scenarios with varying rotation lengths is a challenge in forest management planning. This research aims to forecast forest development and assess the relative consequences of varying rotation lengths on several ecosystem services such as wood production, habitat for biodiversity, carbon sequestration, water provision, soil protection and cultural values. Forest development is simulated with the ETCAP model to examine the long-term effects of various rotation lengths with silvicultural prescriptions on the ecosystem services. Bürücek forest planning unit is used as a case study area with 10,711 ha forests in upper Mediterranean region of Turkey. Shorter rotation lengths are considered one of the main mitigation measures to climate changes in forestry; however, lead to the increased harvest level, net present value, ground water and soil loss, and reductions in the largest stand volume, understory, basal area, carbon storage and the cultural values with less regulated forest structure. The management scenarios with longer rotation lengths, however, have highlighted improvements in the carbon storage, larger standing volume, mean stand age, basal area and cultural values, and reductions in the mean harvest volume, net present value, ground water and soil loss due to larger-even distribution of tree sizes and stand development stages. An aspiration for a higher level of provisioning services for economic motivations may need to be discarded for the sake of enhancing the capacity of forest ecosystems to sequester more carbon and provide better habitat condition for biodiversity conservation with a careful design and selection of rotation lengths. Overall, the choice of optimal rotation length is highly dependent on a desired set of management objectives and target forest structure driven mostly by management interventions with the appropriate type and level of ecosystem services, provided that a thorough understanding of forest dynamics is achieved by considering both risks and uncertainties associated with natural disturbances and socio-economic conditions.

PrivTDSI: A Local Differentially Private Approach for Truth Discovery via Sampling and Inference

Truth discovery is an effective way to identify the aggregated truth of each task among multiple observed data drawn from different workers of varying reliabilities. However, existing studies are insufficient to protect individuals’ privacy, as they either just guarantee the weaker versions of local differential privacy (LDP) or potentially assume that the tasks are independent. In this paper, we, for the first time, investigate the problem of truth discovery while achieving the rigorous LDP for each worker with continuous inputs without the independence assumption. We present a locally differentially private truth discovery approach called <i>PrivTDSI</i> based on sampling and inference with solid privacy and utility guarantees. In <i>PrivTDSI</i> , the server first determines which values of each worker should be sampled according to a sample proportion and sends the indexes of these values to each worker. Then, each worker adds noise into the sampled values for privacy protection and uploads them to the server. After receiving the noisy sampled values from all the workers, the server first infers the unsampled values and then conducts truth discovery based on both the noisy sampled values and the inferred values. In particular, to determine the sample proportion, we formulate a <i>constrained nonlinear programming</i> problem and give a closed-form solution to this problem. Moreover, to determine which values of each worker should be sampled while avoiding the situation where the values of some workers or tasks might not be sampled at all, we develop a two-stage sampling method called <i>TOSS</i> . Furthermore, to infer the unsampled values accurately, we design a quality-aware inference method based on matrix factorization called <i>QualityMF</i> . Experimental results on two real-world datasets and a synthetic dataset demonstrate the effectiveness of <inline-formula><tex-math notation="LaTeX">${PrivTDSI}$</tex-math></inline-formula> .

165 Colorado Immersion Training: Ten years of lessons learned and accomplishments

OBJECTIVES/GOALS: The Colorado Immersion Training in Community Engagement (CIT) provides experiential training in community-based participatory research (CBPR). We summarized evaluations from the first ten years on program outcomes and lessons learned to inform future programming and the field of community research. METHODS/STUDY POPULATION: CIT is a six-month program that includes didactic sessions, group readings and reflections and a one week immersion experience in a Colorado community experiencing health disparities. The Evaluation Center - University of Colorado Denver provides external evaluation services to the Colorado Clinical and Translational Science Institute (CCTSI). Evaluators used three primary methods to collect data to evaluate the program; Document review, interviews, and surveys. Evaluation data were analyzed using the framework of CBPR Principles and the CBPR conceptual logic model to understand potential shifts in researchers’ thinking and actions, as well as to identify the potential for longer-term impact. RESULTS/ANTICIPATED RESULTS: As of 2020, CIT trained 122 researchers. 25 CIT alumni went on to receive 33 CCTSI Pilot Grants. Out of these 33 grants, an additional $8,723,000 of external grant funding was awarded to continue projects. Community Research Liaisons are a crucial component of the program through their efforts to bridge academic researchers and communities. Survey results indicated that community partners reported high levels of satisfactions with the program and shared stories about the impact they have seen in their community. Common challenges for researchers remain 1) protected time and institutional value and, 2) funding opportunities. DISCUSSION/SIGNIFICANCE: CIT has grown CBPR researchers. Similar programs should consider contributing factors: establishing institutional value and funding for CBPR initiatives with protected time for developing and maintaining community relationships. CIT offers a crucial connection between academia and community.

Brief Overview

This article reviews the burden of rotavirus (RV) disease and the role, types, and coverage of RV vaccines (RVVs) in India as well as globally. Establishing the epidemiology and burden of RV disease became an early priority. In the world, diarrheal infections are the second greatest cause of death in children, accounting for one in nine fatalities. Before the widespread use of RV vaccinations, an estimated 453,000 children under the age of 5 died worldwide from RV gastroenteritis (RVGE) in 2008. That's why the World Health Organization (WHO) recommends that RV vaccination should be included in national immunization programs to prevent RVGE. Several vaccines have been invented, and they are an efficient way to shield kids from RVGE. Four RVVs are currently approved by the WHO and accessible worldwide: the monovalent live attenuated human RVV (Rotarix); the pentavalent human-bovine reassortant RVV (RotaTeq); the naturally occurring monovalent neonatal bovine-human reassortant neonatal G9P[11], also known as 116E (Rotavac) and the Pentavalent, human-bovine RVV Rotasiil; all of them WHO prequalified, well tolerated with variable efficacy and protective value distributed globally. To control the RV disease among children, it is crucial to support the development of the next generation of vaccines. If the new vaccine is found to be secure, more efficient, simple to administer, and inexpensive for all, the disease may be controlled more efficiently in the near future.

마스크 스타일 관심도에 따른 구매 선호요인이 만족도에 미치는 영향

In a pandemic situation, masks have proven to us globally the diverse cultural values of life protection and fashion items. The purpose of this study was to understand the effect of purchase preference factors on satisfaction according to the style interest of masks during the pandemic. As a research method, SPSS25.0 statistical program was used for 373 adult men and women. As a result of the study, as the interest in style increased, the preference for color, design, brand, advertising media, and quality, excluding price, increased. In addition, it was confirmed that satisfaction also increased as the perception of each factor of overall purchase preference increased. This suggests that the attitude of changing perception of mask fashion is positive according to the new change in the mask consumption market. In the future, research on mask development focusing on sustainability reflecting consumer needs is needed, and this study is expected to be an important basic data for follow-up research.

The Challenges Facing the Saudi Family in Achieving the Values of Digital Citizenship

Objectives: The study aims to identify the challenges facing the Saudi family in achieving the values of digital citizenship, which are represented by the values of digital respect, digital knowledge, and digital protection. This study focuses on the challenges faced by families in attaining these digital citizenship values, with the hope that specialists, experts, practitioners, and individuals interested in family issues will find guidance to develop plans and proposals for overcoming these challenges.&#x0D; Methods: The social survey method was used with a simple random sample, reaching 335 female employees at the Imam Mohammad Ibn Saud Islamic University in Riyadh. The data were collected using a questionnaire tool during the period from 10/4/1442 AH to 10/5/1442 AH.&#x0D; Results: Several findings have been reached, the most important of which is that the Saudi family faces many challenges in achieving the values of digital citizenship, which are represented by digital respect, digital knowledge, and digital protection, all of which have a moderate degree.&#x0D; Conclusions: The study reveals several recommendations, the most important of which is the development of an integrated national plan to provide community members with the necessary skills to achieve the ideals of digital citizenship.

Rok 2022 v Česku

The article summarizes main events in the months of 2022 in meteorology, climatology, hydrology and ambient air quality. The average annual temperature of 9.2 °C with a deviation of +0.9 °C above the 1991–2020 normal (and +1.7 °C from the 1961–1990 normal) classifies the year as a temperature normal year. The annual precipitation amount of 630 mm classifies the year as normal compared to both the 1961–1990 and 1991–2020 normals. The highest and lowest temperatures, significant precipitation events and, where applicable, higher wind speeds and snowfall, and groundwater statistics are shown for each month. If the level of flood activity in Czechia was reached, it is also listed in the overview. With respect to the air quality, cases exceeding the limit values for human health protection, and smog situations declared are listed. Compared to the 10-year average (2012–2021) the dispersion conditions were significantly better in 2022. Good dispersion conditions, as expressed by the ventilation index for the whole country, were recorded in 320 days (88%), moderately poor dispersion conditions in 42 days (11%) and poor dispersion conditions in three days (1%) in 2022.

Rok 2022 v Česku

The article summarizes main events in the months of 2022 in meteorology, climatology, hydrology and ambient air quality. The average annual temperature of 9.2 °C with a deviation of +0.9 °C above the 1991–2020 normal (and +1.7 °C from the 1961–1990 normal) classifies the year as a temperature normal year. The annual precipitation amount of 630 mm classifies the year as normal compared to both the 1961–1990 and 1991–2020 normals. The highest and lowest temperatures, significant precipitation events and, where applicable, higher wind speeds and snowfall, and groundwater statistics are shown for each month. If the level of flood activity in Czechia was reached, it is also listed in the overview. With respect to the air quality, cases exceeding the limit values for human health protection, and smog situations declared are listed. Compared to the 10-year average (2012–2021) the dispersion conditions were significantly better in 2022. Good dispersion conditions, as expressed by the ventilation index for the whole country, were recorded in 320 days (88%), moderately poor dispersion conditions in 42 days (11%) and poor dispersion conditions in three days (1%) in 2022.

International legal framework regulating military exercises Lawfare potentially associated with military exercises as a hybrid threat

This article analyses international law norms and diplomatic mechanisms concerning militaryexercises. As such a topic is relatively new, with the international legal system being breachedby authoritarian regimes using lawfare, the legal aspects of military exercises have not yetbeen researched and thus require more focus, especially from the standpoint of hybrid threats.International law itself is leaky and lacks enforcement measures, since sanctions are not anelement of the international legal arrangement. It lacks a centralised enforcement mechanism,the principles and rules governing responsibility for wrongful acts require the wrongdoerscooperation, and the mechanisms and procedures to deal with the consequences of suchwrongful acts, including restitution and compensation, are not universally recognised. Mostcountries in the global arena follow the paradigm of the United Nations, where states mustmaintain their relations in a peaceful manner in order to achieve security and stability. However,some undemocratic states, mainly the Russian Federation and the Peoples Republicof China, have been presenting hostile postures towards the Western worlds values, wherehuman life tops the hierarchy of protected values. Traditionally, military exercises have beenused as a messaging tool between strategic competitors and potential adversaries to signaltheir own military strength. Russia and China are fully aware of the lack of hard law concerningthe subject of military exercises; they readily seize the resulting opportunities to create andexploit legal grey zones, as well as to frequently breach international law, while knowing thatlittle can be done against their malevolent conduct.

Полиморфные локусы генов AC026703.1 и HFE ассоциированы с тяжелым течением гипертонической болезни

Hypertension (HT) is characterized by high blood pressure (BP) and is one of the most common diseases in the world. At the moment, there is information in the literature about 1.5 thousand single-nucleotide polymorphic loci (SNP) associated with HP and BP according to genome – wide studies (GWAS). At the same time, replicative studies of GWAS significant genes in various populations, including Russian ones, are necessary. The aim of the study:To study the relationship of GWAS-significant polymorphic loci for HP with the stages of the disease. Materials and methods: For this study, two samples of patients with HT were formed: patients with stages 1-2 (n=384) and patients with stage 3 HT (n=555), and a control group of 466 people. For the experimental study, ten polymorphic loci of candidate genes associated with the development of HT were selected according to the data of GWAS conducted earlier. Associations were studied by the logistic regression method with a pperm level &lt;0.05. Results: The association of two GWAS significant candidate genes AC026703.1 (rs1173771) and HFE (rs1799945) with the risk of severe HT formation (stage 3 of the disease) was revealed. Allelic variant A rs1173771 (G/A) AC026703.1 has a protective value for the severe course of the disease (ORdom=0.63 and 95%CIdom 0.41-0.98 pperm=0.048). The minor genotype GG rs1799945 (C/G) HFE significantly (more than 3 times) increases the risk of developing stage 3 HT (ORrec=3.25 and 95%CIrec 1.25-8.42 pperm=0.017). Associations of GWAS significant of polymorphic loci for HT with the development of stages 1-2 of the disease have not been established. Conclusion: Polymorphisms rs1799945 of the HFE gene (OR=3.25) and rs1173771 of the AC026703.1 gene (OR=0.63) are associated with the risk of developing stage 3 HT