In order to study indoor temperature distribution in a large space and thermal comfort of human, an environmental test and questionnaires were carried out at an airport in Xi’an in summer. The results show that the temperature distribution in the space is asymmetric. The room temperature increases from cooling floor to 0.1m high, but then it has little change within 1.5m high. However, the temperature fluctuation in horizontal is significantly influenced by internal equipment, lighting, elevator and etc. According to the environmental parameters and subjective voting, 55% of the PMV values are greater than 0.5, and more than half of the thermal feelings near the heat source and glazing curtain wall are “warmer”. Properly increasing the wind speed of air vent could effectively improve the environmental comfort.