Index Values Research Articles

Turkish validity and reliability study of the Baby-Led Weaning Scale

AimThe aim of this study was to test the psychometric properties of the Turkish version of the Baby-Led Weaning Scale for parents with babies/children aged from 6 to 30 months. MethodsThe sample for this methodological research consisted of parents with babies aged 6 to 30 months between March and June 2024 in a city in eastern Turkey. The data were collected from 354 parents for exploratory factor analysis, from 213 parents for confirmatory factor analysis, and from 70 for the test-retest reliability study. The data were collected using the “Descriptive Information Form”, the “Baby-Led Weaning Scale” and the “Transition to Complementary Feeding Behaviors Scale” (TCFBS). ResultsThe total content validity index score of the Baby Led Weaning Scale was 0.92 and the content validity rate score was 0.92. The TCBFS was used for the concordance of the scale with similar scales. During the measurements, the intra-observer reliability of the Baby Led Weaning Scale was statistically significant (p < 0.001). The Exploratory Factor Analysis revealed a three-factor structure, explaining 611.5 % of the variance. The fix index values were χ2/df = 3.036, RMSEA = 0.069, GFI = 0.902, CFI = 0.907 and AGFI = 0.857, IFI = 0.928, and TLI = 0.921.The Cronbach alpha values of the scale were in the range of 0.706 and 0.831. ConclusionAs a result, the Turkish adaptation of the Baby Led Weaning Scale is a valid and reliable measurement tool. Practical implicationsThe Baby-Led Weaning Scale can be used as a simple and objective tool to measure the knowledge level of parents with babies/children aged 6 to 30 months.

Trace element concentrations and associated human health risk assessment in canned tuna, city of Neyshabur, Iran

Seafood is considered a healthy and nutritious food, but the presence of toxic substances in such foods is a serious problem. The present study aimed to analyze the concentration of some toxic metals in seafood and evaluate their noncarcinogenic risks to consumers. Samples were digested according to the Association of Official Agricultural Chemists (AOAC) standard. The heavy metals concentration of Cd, Ni, Hg, Pb, and Sn in 30 canned tuna samples were determined using an inductively coupled plasma optical emission spectroscopy (ICP-OES). The mean concentrations of Cd, Ni, Sn, Pb, and Hg were 0.7, 0.49, 1.03, 0.31, and 0.12 µg g− 1, respectively. Based on these results, the concentrations of Cd, Sn, and Hg in samples met the required standards. However, the concentrations of Ni and Pb in some samples were higher than the permissible limits. The mean values of Sn, Ni, Pb, Hg, and Cd in samples followed a decreasing order. Since the values of the health risk index for these samples were lower than the HI and HRI risk threshold (<1), they can be consumed without any problems arising. Highlights The metal concentration was measured in the four most popular brands of canned fish sold in Neyshabur City, Iran. Some samples exceeded the maximum permissible level of nickel (Ni) and lead (Pb). A significant correlation was observed between Ni concentration with Pb and Hg concentrations and Pb concentration with Cd concentration. The values of the health risk index (HRI) for noncarcinogenic health risks were lower than 1. The calculated Hazard index (HI) for adult and child consumers was less than 1. The HI values were greater for children than for adults.

Exploring the impact of CuCl2 modification on structural variations and dielectric constant in bismuth borate tellurite glasses

Copper chloride doped boro-tellurite-based glass series with compositions 60TeO2-(25-x) Bi2O3–15B2O3-xCuCl2 (x = 0, 5, 10, 15, and 20) were synthesized using the traditional melt-quench procedure. The X-ray diffraction patterns of the examined glasses reveal their amorphous nature. The effect of CuCl2 addition on the glass network/structural units was studied using vibrational (FTIR/Raman) spectroscopy, and CuCl2 inclusion in the glass matrix resulted in a transformation from compact TeO4 to TeO3 structural units This shows that copper chloride acts as a modifier in the examined glass series, resulting in the creation of non-bridging oxygen (NBOs), meaning that the loosening of the glass network is further supported by a decrease in the glass transition temperature as CuCl2 content increases. UV–Vis DRS spectra of examined glasses reveal an absorption band corresponding to the typical transition of Cu2+ ions from 2B1g → 2B2g, situated in deformed octahedral sites in absorption spectra. As Cu+ concentration rises, the indirect optical band gap values drop from 2.94 eV to 1.75 eV. The metallization criterion values lie between 0.383 and 0.300 suggesting that these glasses are potential candidates for nonlinear optical applications. With an increase in Cu+ concentration, the values of molar refractive index (Rm) and molar electronic polarizability αm increases from 22.412 to 26.205 and 8.894 to 10.398 respectively, which correlate with increasing dielectric constant (ε′) values as the Cu+ amount increases. Further dielectric studies reveal non-Debye-type relaxation behaviour.

Impact of Cardio-Ankle Vascular Index on Future Cancer in Patients With Coronary Artery Disease.

Cardiovascular risk factors are associated with increased risk of future cancer. However, the relationship between quantitative parameters of atherosclerosis and future cancer risk is unclear. A total of 1,057 consecutive patients with coronary artery disease was divided into 2 groups according to the cutoff value of the cardio-ankle vascular index (CAVI) derived by receiver operating characteristic curve analysis: low CAVI group (CAVI <8.82; n=487), and high CAVI group (CAVI ≥8.82; n=570). Patients in the high CAVI group were older and had a higher prevalence of diabetes, chronic kidney disease, anemia and history of stroke compared with patients in the low CAVI group. There were 141 new cancers during the follow-up period. The cumulative incidence of new cancer was significantly higher in the high CAVI group than in the low CAVI group (P=0.001). In a multivariate Cox proportional hazard analysis, high CAVI was found to be an independent predictor of new cancer diagnosis (hazard ratio 1.62; 95% confidence interval 1.11-2.36; P=0.012). In the analysis of individual cancer types, high CAVI was associated with lung cancer (hazard ratio 2.85; 95% confidence interval 1.01-8.07; P=0.049). High CAVI was associated with the risk of future cancer in patients with coronary artery disease.

Population Mobility and City Livability: An Empirical Study from Java Cities, Indonesia

Population mobility is one of the key factors contributing to the growth of the urban population. Consequently, cities encounter challenges related to livability, including limited access to basic services in education and healthcare, reduced safety, limited transportation accessibility, and affordability of recreational facilities. Literature on population mobility frames urban livability as a non-market good, thus requiring an approach to implicitly derive its value to quantify it into a city livability index. As quantitative research, this study aims to calculate the value of the city livability index and assess its impact on population mobility. We use secondary data, national socio-economic surveys and village potential published by the Central Bureau of Statistics. The findings of this study indicate that cities with high index values typically serve as capitals and hubs of government, commerce, industry, and services. Empirical findings found that livability substantially influences population mobility into cities, with basic services like education, healthcare, and public mass transportation playing pivotal roles. We recommend that city governments provide comprehensive and high-quality facilities to enhance the living experience for their residents.

Measuring ecological effects and policy mechanisms of urban land use transition – a case study of Xi'an, China

ABSTRACT Measuring ecological effects and policy mechanisms of urban Land Use Transition (LUT) is the key to understanding regional environmental changes and achieving sustainable urban developments. This paper illustrates and demonstrates a formal method for measuring the ecological effect of LUT characterized by Ecological Security Index (ESI) and Ecosystem Value (ESV), and enhanced with a correlational analysis between the ecological effect model and urban policy mechanism. Using Xi'an, a major capital city of western China as a case study, based on multi-temporal Thematic Mapper (TM) remote sensing images, Digital Elevation Model (DEM) and relevant statistical data, the results show that the method using ESI and ESV, together with the Land Use Transition Probability Matrix (LUTPM) can comprehensively measure the ecological effects of LUT process in Xi'an from 2000 to 2020. The results show that due to the impact of urban expansion, regional construction land increased significantly (by 67.07%), while farmland decreased considerably (by 13.12%). The farmland and forestland around the main urban area of Xi'an were centrally converted into construction land, yet the mutual transition of other types of land was relatively scattered. The total amount of ESV has slightly increased from 40.1 billion yuan to 42.8 billion yuan, and the proportion of ecological service function value presents a decreasing trend in regulation function (65%), support function (22%), supply function (9%), and cultural function (4%). The ESI value slightly decreased from 0.517 to 0.512, and overall it is still in a state of ecological security. The trend of ESV and ESI decreasing from mountainous areas to plains indicates that high-intensity human activities in plain areas have had a significant impact on the ecological environment. The correlation analysis between policy mechanisms and ecological effects indicates that ecological protection policies have improved the ecological environment and maintain ecological security (high ESV-high ESI mode), and may also have limited economic activities and been detrimental to the security of urban composite ecosystems (high ESV-low ESI mode). Spatial expansion policies have driven the rapid growth of construction land and threatened ecological security (low ESV-low ESI mode). Zoning adjustment policies have led to the transformation of ecological land to construction land, threatening ecological security and reducing ESV (low ESV-low ESI mode), and may also have promoted industrial upgrading and economic development, providing economic assurance for improving ecological security (low ESV-high ESI mode). These comprehensive findings provide valuable insights for understanding the ecological effects and policy mechanisms of LUT in Xi'an for achieving sustainable urban development, and demonstrate and explore a novel method to more appropriately and effectively measure LUT by combining ESV and ESI.

Curcumin-cyclodextrin inclusion complexes embedded in intrinsically active nano-assemblies: Preparation, characterization, antibacterial and antibiofilm activity against ESKAPE pathogens

Curcumin loaded β-CD inclusion complexes (CCDs) embedded in intrinsically active rhamnosomes (CCDRs) were developed as alternative antimicrobials at the nano-scale to control ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) pathogens. The physicochemical analysis of CCDRs demonstrated that the addition of glycolipids (rhamnolipids) during the development of liposomes (phospholipids based) provided stability while the average size (158±5 nm) and polydispersity index (PDI) values of 0.2 demonstrated homogenous population of rhamnosomes. The incorporation of rhamnolipids with phospholipids increased the zeta potential to -45±1 mV with 76±1 % encapsulation efficiency for curcumin with enhanced photochemical and storage stability. In vitro, release studies demonstrated sustained release of curcumin due to its incorporation in β-CD molecular buckets, which were loaded in the aqueous liposomal core. These CCDRs with intrinsic antibacterial and antibiofilm potential enhanced the antimicrobial spectrum against ESKAPE pathogens demonstrating synergism between curcumin and rhamnolipids, by targeting multiple sites of bacterial cells and biofilms as compared to conventional antibiotics. Our study outlines that rhamnolipids and curcumin loaded inclusion complexes together offer an exciting potential for functionalized liposomal delivery systems that would be promising for the development of effective alternative therapeutics against ESKAPE pathogens.

Development and validation of the mpox stigma scale (MSS) and mpox knowledge scale (MKS)

BackgroundFew validated brief scales are available to measure constructs that may hinder mpox-related prevention and care engagement, such as knowledge and stigma. Both are highly salient barriers to infectious disease care and disease understanding, precursors to evaluating one’s risk and need to, for example, accept vaccination. To address this gap, we developed and validated the Mpox Stigma Scale (MSS) and Mpox Knowledge Scale (MKS).MethodsAs part of a full-scale clinical trial, we offered an optional mpox survey to participants who self-identified as African American or Black, were 18–29 years old, and lived in Alabama, Georgia, or North Carolina (2023, N = 330). We calculated psychometric properties through confirmatory factor analyses (CFA) and applied Comparative Fit Index (CFI), Goodness of Fit Index (GFI), and Tucker-Lewis Index (TLI) values equal to or exceeding 0.90 and Root Mean Square Error of Approximation (RMSEA) and Standardized Root Mean Square Residual (SRMR) values less than 0.08 to determine adequate model fit. We computed internal reliability using Cronbach’s alpha and calculated Pearson or Spearman correlation coefficients between the MSS and MKS and related variables.ResultsFor the MSS, CFA results showed that the one-factor model fit the data well (χ2(df = 5, N = 330) = 34.962, CFI = 0.97, GFI = 0.99, TLI = 0.94, RMSEA = 0.13, SRMR = 0.03). For the MKS, the one-factor model provided a good fit to the data (χ2(df = 6, N = 330) = 8.44, CFI = 0.99, GFI = 0.99, TLI = 0.95, RMSEA = 0.15, SRMR = 0.02). Cronbach’s alphas were MSS = 0.91 and MKS = 0.83, suggesting good to excellent reliability. The MSS was correlated with the MKS (r = .55, p < .001), stigmatizing attitudes (r = .24, p < .001), attitudes towards mpox vaccination (r=-.12, p = .030), and worry about contracting mpox (r = .44, p < .001). The MKS was correlated with worry about contracting mpox (r = .30, p < .001) and mpox disclosure (r=-.16, p = .003).ConclusionsThe MSS and MKS are reliable and valid tools for public health practice, treatment and prevention research, and behavioral science. Further validation is warranted across populations and geographic locations.Trial RegistrationClinicalTrials.gov NCT05490329.

A comprehensive evaluation of Cell Elution Method (CEM) for forensic DNA analysis from smoked cigarettes

Cigarette stubs are commonly encountered trace DNA samples at crime scenes. Standard laboratory practice typically involves direct lysis of the stub for DNA extraction, leading to the co-extraction of DNA-degrading and inhibiting constituents from smoke and tobacco. This process can result in lower-quality DNA profiles. There has been limited focus on developing specific sample processing techniques that minimize these degrading agents and inhibitors before DNA extraction, which could significantly enhance the quality of DNA profiles. This study evaluates a previously established Cell Elution Method (CEM) against the conventional Direct Lysis Method (DLM) for DNA extraction from cigarette stubs. DNA quantity, quality, and subsequent STR profiles were assessed in 80 smoked cigarette stubs, comprising both flavoured and unflavoured types. While CEM exhibited comparable DNA yield from both flavoured (0.17 ng) and unflavoured (0.19 ng) cigarettes, DLM showed significant variability in average DNA yield for unflavoured (0.05 ng) and for flavoured (0.25 ng) cigarettes. Notably, CEM-treated samples demonstrated lower Degradation Index (DI) values compared to DLM-treated ones for both the types of cigarettes. Consequently, STR profiling success rates were higher with CEM, with 95 % of flavoured and 55 % of unflavoured samples yielding informative profiles, compared to 80 % and 0 %, respectively, for DLM. In unflavoured stubs, Amelogenin marker amplification was achieved in 35 % of CEM-treated samples, significantly outperforming the 5 % success rate with DLM. Additionally, CEM resulted in higher average allele recovery rates for both flavoured (58.98 %) and unflavoured (33.41 %) samples compared to DLM. These findings indicate that CEM outperforms DLM in producing higher-quality DNA profiles from cigarette stubs. Thus, CEM can be a choice of method for processing cigarette stub prior to DNA extraction.

Genome resequencing reveals genetic status of Macrobrachium rosenbergii populations in China

The giant freshwater prawn (Macrobrachium rosenbergii) has been widely cultured in China since 1990s. In this study, 189 individuals were sampled from 10 distinct populations, including original populations introduced from abroad and domesticated strains in China, namely Florida (FD), "Nantaihu No.2" (NT), Vietnam (YN), Sri Lanka (SK), Bangladesh (ML), Thailand (TG), Taiwan (TW), "Shufeng No.1" (SF), Zhengda (ZD) and New Myanmar (NMD). The genetic diversity and population structure of these populations were analyzed based on a dataset of 300,828 genome-wide SNP loci. The population structure analysis showed that the 10 populations shared 4 ancestors, and the domestic populations (i.e., SF, ZD, TW and NT) shared a common ancestor. The phylogenetic analysis showed that the 10 populations were grouped into 4 branches, with all the domestic populations clustering together. Estimation of fixation index (Fst) values revealed relatively lower Fst values among the domestic populations, in contrast to the more significant differences observed between domestic and foreign-origin populations. Gene flow analysis revealed three significant events of genetic exchange among the 10 populations: (1) from YN to the common ancestor of FD, TG and the domestic populations, (2) from NMD to the common ancestor of TG and FD, and (3) from the common ancestor of NMD, YN, ML and SK to ZD population. In addition, selective sweep analysis, utilizing Fst and nucleotide diversity (Pi) estimations, was conducted on representative populations (i.e., ML and SF), and 7 positively selected genes were identified, including Prospero Homeobox 1 (Prox1), Forkhead Box L1 (Foxl1), Tousled Like Kinase 2 (TLK2), G Protein Subunit Alpha 14 (Gna14), Uronyl 2-sulfotransferase (Ust), MAX Network Transcriptional Repressor (Mnt) and Importin-9 (Ipo9). These findings contribute to elucidating the breeding potential of the introduced populations and provide insights into the genetic status of the domestic breeding strains of M. rosenbergii in China.

Assessing the impacts of vegetation loss and land surface temperature on Surface Urban Heat Island (SUHI) in Gazipur District, Bangladesh

Rapid replacement of vegetated land with impermeable land (built-up areas) is a major factor in the increase in Land Surface Temperature (LST), while increased LST worsens the temperature in cities and creates the Surface Urban Heat Island (SUHI) effect. The study aims to measure vegetation loss and Land Surface Temperature of the Gazipur district between 2000 and 2020 and explore the relationship among Normalized Difference Vegetation Index (NDVI), LST, and Urban Thermal Field Variance Index (UTFVI). The Landsat TM/OLI images with minimum cloud coverage have been used to derive different indices. The mean NDVI values are 0.21, 0.16, and 0.22 in 2000, 2010, and 2020 respectively which indicates a general improvement in the health of the vegetation. Besides, the highest LST values throughout 20 years, represent a general increasing trend. As a consequence, different land covers have experienced fluctuations in mean temperature. The result shows that the mean temperature of bare land, buildup, vegetation, and waterbody has increased by 4.77, 2.01, 2.25, and 2.23 °C respectively from 2000 to 2020. The strongest SUHI zone’s area grew by about 28% between 2000 and 2020. Additionally, the highest index value of UTFVI was 0.39 in 2000 and grew to 0.43 in 2010. It changed to 0.49 in 2020, or ten years later. Thus, the SUHI effect’s increasing intensity is visible. Also, regression analysis has been used to explore the correlation between the derived indices. Stakeholders from different sectors like urban planners and policymakers may take insights from this study to work to promote greenery for a healthy urban environment.

Ethanolic Cashew Leaf Extract Encapsulated in Tripolyphosphate–Chitosan Complexes: Characterization, Antimicrobial, and Antioxidant Activities

Ethanolic cashew leaf extract (ECL-E) is rich in phenolic compounds and shows remarkable antioxidative and antimicrobial activities. Encapsulation could stabilize ECL-E as the core. Tripolyphosphate (TPP)–chitosan (CS) nanoparticles were used to load ECL-E, and the resulting nanoparticles were characterized. The nanoparticles loaded with ECL-E at different levels showed differences in encapsulation efficiency (47.62–89.47%), mean particle diameters (47.30–314.60 nm), positive zeta potentials (40.37–44.24 mV), and polydispersity index values (0.20–0.56). According to scanning electron micrographs, the nanoparticles had a spherical or ellipsoidal shape, and a slight agglomeration was observed. The appropriate ratio of CS/ECL-E was 1:3, in which an EE of 89.47%, a particle size of 256.05 ± 7.70 nm, a zeta potential of 40.37 ± 0.66 mV, and a PDI of 0.22 ± 0.05 were obtained. The nanoparticles also exhibited high antioxidant activities, as assayed by DPPH and ABTS radical scavenging activities, ferric reducing ability power (FRAP), and oxygen radical absorbance capacity (ORAC). Low minimum inhibitory concentration and minimum bactericidal concentration were observed against Pseudomonas aeruginosa (9.38, 75.00 mg/mL) and Shewanella putrefaciens (4.69, 75.00 mg/mL). In addition, ECL-E loaded in nanoparticles could maintain its bioactivities under various light intensities (1000–4000 Lux) for 48 h. Some interactions among TPP, CS, and ECL-E took place, as confirmed by FTIR analysis. These nanoparticles had the increased storage stability and could be used for inactivating spoilage bacteria and retarding lipid oxidation in foods.

Anisotropy in Chip Formation in Orthogonal Cutting of Rolled Ti-6Al-4V

Abstract The increasing demand for titanium alloys in aerospace and medical device industries stems from their lightweight and high strength properties. Enhancing machining technologies for titanium alloys is critical for reducing production time and costs. This study investigates the anisotropy in machining of rolled titanium alloy plates with orthogonal cutting tests. The mechanical properties of these plates exhibit anisotropy due to the rolled texture of hexagonal close-packed (HCP) structure. Observations of chip morphologies and cutting forces are conducted with changing cutting direction angles relative to the rolling direction. The result shows that the chip morphology is influenced by the cutting direction angle. When cutting parallel to the rolling direction with an orthogonal cutting tool with 30° rake angle, serration free chips are produced, while perpendicular cutting results in serrated chips. The chip thickness, the serration pitch, and the serration length vary with the cutting direction angle. The serration length is associated with an anisotropic deformation index, which characterizes anisotropic behavior in chip formation. Lower index values suppress the formation of undesirable serrated chips.

Predictive Value of Neutrophil-Lymphocyte Ratio and Other Inflammation Indices in Febrile Seizures in Children.

Objective: There is increasing evidence for the effect of inflammation on the etiology of febrile seizure (FS) patients. We aimed to investigate the role of easily accessible inflammatory markers such as the neutrophil-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-lymphocyte-platelet ratio (NLPR), and pan-immune-inflammation value (PIV) in febrile seizure. Methods: A total of 300 children, including 100 with febrile convulsions (FS), 100 febrile controls (FCs), and 100 healthy controls (HCs), were included in this retrospective study. The FS group was compared with the FC and HC groups in terms of these inflammatory indexes. Results: Between the FS group and the FC group, the neutrophil count was significantly higher in the FS group (p = 0.001) and the lymphocyte count was significantly lower (p < 0.001). The NLR (p < 0.001), SII (p < 0.001), SIRI (p < 0.001), NLPR (p < 0.001), and PIV (p < 0.001) were significantly higher in the FS group than in both the FC and healthy control groups. The optimal cut-off values for predicting FS in febrile conditions were 3.59> for NLR, >870.47 for SII, >1.96 for SIRI, 0.96> for NLPR, and >532.75 for PIV. Conclusions: The inflammatory indices are inexpensive, easily accessible hematological markers that can contribute to the diagnosis of FS.

Abdominal obesity is associated with increased worsening renal function risk in patients with heart failure with preserved ejection fraction

BackgroundWorsening renal function (WRF) is a frequent comorbidity of heart failure with preserved ejection fraction (HFpEF). However, its relationship with abdominal obesity in terms of HFpEF remains unclear. This study aimed to evaluate the value of waist circumference (WC) and body mass index (BMI) in predicting WRF and examine the correlation between abdominal obesity and the risk of WRF in the HFpEF population.MethodsData were obtained from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial. Abdominal obesity was defined as WC ≥ 102 cm for men and ≥ 88 cm for women. WRF was defined as doubling of serum creatinine concentration from baseline. Restricted cubic splines and receiver operating characteristic curves were used to evaluate the value of WC and BMI in predicting WRF. Cumulative incidence curves and cox proportional-hazards models were used to compare patients with and without abdominal obesity.ResultsWe included 2,806 patients with HFpEF in our study (abdominal obesity, n: 2,065). Although baseline creatinine concentrations did not differ, patients with abdominal obesity had higher concentrations during a median follow-up time of 40.9 months. Unlike BMI, WC exhibited a steady linear association with WRF and was a superior WRF predictor. Patients with abdominal obesity exhibited a higher risk of WRF after multivariable adjustment (hazard ratio: 1.632; 95% confidence interval: 1.015–2.621; P: 0.043).ConclusionsAbdominal obesity is associated with an increased risk of WRF in the HFpEF population.Trial registrationURL: https://beta.clinicaltrials.gov. Unique identifier: NCT00094302.

Establishing minimal clinically important differences for the quality of life scale QLICD-SLE for patients with systemic lupus erythematosus based on ROC curve

The minimal clinically important difference (MCID) is an important concept with big appeal in a field struggling to interpret quality of life (QOL) and other patient-reported outcomes (PRO), is also a bridge between statistics and clinical medicine. This study uses the ROC curve to formulate the MCID value of the Quality of Life Instruments for Chronic Diseases of Systemic lupus erythematosus (QLICD-SLE V2.0) scale. Using the representative item “In general, would you say your health is” of the MOS item short form health survey(SF-36) as an anchor, the questionnaire of QLICD-SLE V2.0 and the anchor item were used to investigate the patients on the first day of hospitalization, and the day before the patient was discharged. 279 patients with lupus erythematosus were participated in this longitudinal follow-up study. The ROC curve was constructed by using the classification based on the anchor item as the gold standard and the difference score of the scale as the test variable. The cut-off point corresponding to the maximum value of the Youden index in the ROC curve is taken as the minimum clinical importance difference (MCID) value of the QLICD-SLE (V2.0) scale. The Results showed that the MCID of physical domain, psychological domain, social domain, general module, specific module and QLICD-SLE (V2.0) total scale are 8.3, 2.3, 2.5, 2.7, 9.2 and 3.2, respectively. Area under the ROC curve of QLICD-SLE (V2.0) is 0.898, P (Area = 0.5) < 0.001, the sensitivity is 100%, the specificity is 66.9%. It concluded that if the total scores after treatments changes at least 3.2 points positively, the treatment intervention can be considered as clinically significant. It is more convincing to use the corresponding cut-off point as the MCID for ROC curve method can visualize the sensitivity and specificity.

Analysis of Wedge Angle Variations in the Treatment Planning System Based on Dose Volume Histogram on Ca Mammae Sinistra

Breast cancer ranks first in terms of the highest number of cancers in Indonesia and is one of the first contributors to cancer deaths. According to IARC, radiotherapy is one of the most important modalities in the treatment of breast cancer. Radiotherapy is a type of treatment that uses ionizing radiation to kill cancer cells without damaging surrounding healthy tissue. To obtain an even or homogeneous dose distribution on an uneven skin surface, a wedge is used so that the radiation given to the tumor area is truly optimal and the surrounding healthy tissue receives a minimum dose. This research was carried out by evaluating the Planning Target Volume (PTV) value based on ICRU-83 and dose distribution in Organs at Risk (OAR) based on QUANTEC standards at four different wedge angles, namely 15°, 30°, 45°, and 60°, used the 3D-CRT technique of tangential radiation with a dose of 50 Gy in 25 fractions on 5 left-sided breast cancer patients. The research results showed that the average Homogeneity Index (HI) values for the 15°, 30°, 45° and 60° wedges were 0.286, 0.346, 0.436 and 0.578, respectively. In the left and right lung dose distribution, the results obtained for the 15°, 30°, 45°, and 60° wedge were respectively 2231.4 and 116.2 cGy, 2257.8 and 114.6 cGy, 2141 and 100 cGy, and 2059.4 and 88.8 cGy. For the average dose distribution to the heart, the values obtained at the 15°, 30°, 45°, and 60° wedges were 2005.6 cGy, 2040.4 cGy, 1930.6 cGy, and 1844.4 cGy, respectively. where the average dose received by OAR is still below the limit allowed by QUANTEC. Using a wedge angle of 15° provides a homogeneous dose distribution for the PTV and a wedge angle of 60° provides the lowest dose distribution for the OAR.

Improving thermal comfort using biomimicry in the urban residential districts in New Aswan city, Egypt

AbstractEgypt tends to construct new cities to provide social housing for its citizens. However, the planning of urban residential districts (URDs) in these cities lacks provisions for natural ventilation (NV), and indoor-outdoor thermal comfort, resulting in increased energy consumption during the summer months. This research aims to create a sustainable design through biomimicry to reduce the universal thermal climate index (UTCI) values in the URD in New Aswan thereby enhancing outdoor thermal comfort and reducing energy consumption inside buildings at the level of URD. In this research, the approach of prairie dogs in building their burrows was followed to rearrange and reorient the buildings. Autodesk CFD, Rhino7, Grasshopper, Ladybug, Honeybee, and Dragonfly software was used in the simulation. The rearrangement of the buildings, specifically the oriented design in the east-west direction, caused a difference in pressure between the buildings, leading to improved NV between the buildings. The improvement of NV resulted in a 4.2 °C reduction in UTCI values during specific hours over the six different days in the six summer months, resulting in significant energy savings of 10407.28946 KWh in the URD. The occurrence of a pressure difference between buildings not only improved NV but also enhanced outdoor and indoor thermal comfort, promoting energy conservation. Therefore, careful consideration of the arrangement and orientation of buildings is essential to establish sustainable URDs. Although the difference between the results is slight, it creates substantial differences in the long term for UTCI values, thus the energy conservation in the URDs.

Plasmonic sensor using generative adversarial networks integration

Machine learning (ML) has emerged as a pivotal force in enhancing the capabilities of sensing technologies across a broad spectrum of applications, from environmental monitoring and biosensing to agriculture, industrial automation, and so on. This study explores integrating ML techniques with photonic crystal fiber (PCF)-based plasmonic sensing techniques to elevate sensor performance. The PCF has two open channels to augment mode coupling, effectively reducing the gap between the analyte channel and core. Moreover, a thin layer of gold within the open channels of the PCF initiates efficient plasmon generation. The results demonstrate a maximum wavelength sensitivity of 9000 nm/refractive index unit (RIU), which can detect a wide range of analyte refractive index (RI) values from 1.33 to 1.40. The sensor exhibits the maximum amplitude sensitivity of 490.41 RIU−1. It also boasts a resolution of 1.11 × 10−5 RIU and the maximum figure-of-merit (FOM) achieved is 138.04 RIU−1 at an analyte RI of 1.39. Furthermore, this research introduces a method utilizing generative adversarial networks (GAN) to expand training data for an artificial neural network (ANN) model. This approach substantially improves the prediction of confinement loss across various analytes and wavelengths in a unique geometric configuration. The sensor’s versatility makes it ideal for various applications, including chemical sensing and medical diagnostics.

Impact of the high-speed solar wind stream over the low-latitude ionospheric system – a study combining Indian MOM and InSWIM observations

ABSTRACT In this study, we map the origin, acceleration, and propagation of the high-speed solar wind streams (HSS) and observe their impact on the low-latitude Earth’s ionosphere. Data from radio-sounding experiments conducted by the Indian Mars Orbiter Mission (MOM) from 2015 May 9–19 is analysed to understand the solar wind speed’s evolution at various helio-centric distances. The slope of the turbulence spectrum from 25 to 35 Rs was in the range of 0.2–0.4, indicative of the underdeveloped turbulence corresponding to the high-flow streams. It coincided with the appearance of the earth-facing coronal holes as observed in the coronal EUV images. The particle bulk velocity at L1 showed that the speeds began to rise from 400 km s−1 on May 11th–12th, reaching a peak of around 800 km s−1 on May13th–14th, followed by a gradual decrease to the average slow speeds. Geomagnetic disturbances during the same period manifested as a dip in the DST index values. The GNSS (Global Navigation Satellite System) data from the InSWIM (Indian network for Space Weather Impact Monitoring) network show an appreciable increase in the VTEC (vertical total electron content) of the ionosphere on disturbed days in entire low-latitude ionospheric region in the Indian sector. All these observed parameters correlate well with the HSS arrival. This is a unique study that connects the propagation of the HSS and its impact on near-Earth’s environment from the different vantage points in interplanetary space and proposes the application of Radio beacons to improve space weather forecasting.