Value Of Fit Research Articles

Statistical optimization of lipase production in solid-state fermentation by Aspergillus tamarii NDA03a and application of the fermented solid as a biocatalyst for biodiesel production

Background and objective Biodiesel, an attractive alternative fuel, is defined by the American Society for Testing and Materials (ASTM) as fatty acid methyl esters (FAME). Biodiesel is an ecofriendly fuel compared with many other transportation fuels. The aim of this study was to implement the statistical approaches for optimization of Aspergillus tamarii NDA03a mutant G lipase produced in solid-state fermentation (SSF), and then application of the dried fermented solid as a biocatalyst for biodiesel production from waste frying oil (WFO). Materials and methods A. tamarii NDA03a mutant (3G) was previously selected as a good lipase producer. Five oil residue meals were evaluated in the presence of wheat bran (WB) for their potential as enzyme inducers and substrates for the production of 3G lipase by SSF. The best oil residue meal was selected and used in subsequent experiments. The fermented solid thus obtained was collected, lyophilized, and used as a biocatalyst for waste frying oil transesterification to FAME. To optimize SSF conditions for lipase production using 3G, a Plackett–Burman design was used at first to screen the critical factors from several process variables, and finally, a central composite design was applied to further estimate the relationship between the variables and response as well as optimize the levels. Response was measured in terms of FAME yield. To verify the adequacy and accuracy of the model, validation experiments were also carried out. Results and conclusion The most favorable oil residue meal that enhances 3G lipase production by SSF was black cumin meal. Results of the Plackett–Burman design revealed that the factors contributing to the main effect were incubation temperature, incubation period, and moisture content. The optimal SSF conditions for lipase production were WB 10 g, black cumin meal 6% (w/w of WB), pH 8, temperature 28°C, moisture content 40%, molasses 1% (w/w of WB), and incubation period 3 days. Under these optimized conditions, produced FAME yield (65.55%) increased by 58% compared with the basal medium (41.46%). A good agreement between the experimental (65.55%) and predicted (65.03%) values was detected. The significance of this model was confirmed by its probability value and lack of fit (P<0.05) and clearly showed that the model was sufficient to describe the correlation between the FAME yield and the tested variables. The obtained results ascertained the success of response surface methodology as an efficient technique to optimize the lipase production in SSF and consequently the ability of application of the dried fermented solid as a biocatalyst for biodiesel production.

Exploring the Effect of a Promotion and Prevention Regulatory Focus on Subjective Responses to Vaginal Sensations in a Laboratory Research Design

BackgroundSelf-regulation is an important process to explain sexual, emotional, and pain-related responses in the context of genital pain. Although highly relevant, self-regulatory focus theory is not well integrated into the literature on genital pain. AimThis study explored the impact of a promotion and prevention regulatory focus on genital pain responding. Sex would typically endorse a promotion focus, whereas pain during sex is likely to provoke a prevention focus oriented toward harm avoidance and safety. MethodWe induced gradually increasing vaginal pressure in a sample of 56 women using an intra-vaginal balloon that simulated potentially painful vaginal sensations. Women were first primed with a promotion vs prevention focus by making them list their ideals vs responsibilities as a sexual partner. We measured trait regulatory focus, pleasant and painful vaginal pressure sensations, sexual arousal, expectations, and approach-avoidance motivational tendencies. Main outcomeThe effect of trait and state promotion and prevention regulatory focuses on the appraisal of vaginal pressure and sexual arousal. ResultsWhen primed with a prevention compared with a promotion focus, women with a predominant prevention orientation reported less sexual arousal, less pleasant vaginal pressure appraisals, and lower approach tendencies regarding sexual stimuli. Women who experienced a match between their state and trait promotion focus appraised the vaginal pressure as less painful. No significant effects of regulatory focus were found on the expectancy measures. Strengths and LimitationsWe provided first evidence on self-regulatory motivation in the context of genital pain responses using an experimentally controlled laboratory design. Our sample was small and consisted of young students without (a clinical diagnosis of) genital pain, which limits our conclusions on the effect of promotion vs prevention regulation on genital pain responses. Clinical ImplicationsFuture research is needed to examine the clinical value of self-regulation and regulatory fit and to identify possible ways to target self-regulatory motivation in clinical interventions of genital pain. ConclusionSelf-regulatory focus theory has clear potential to explain the sexual and motivational correlates of genital pain.Dewitte M and Kindermans H. Exploring the Effect of a Promotion and Prevention Regulatory Focus on Subjective Responses to Vaginal Sensations in a Laboratory Research Design. J Sex Med 2021;18:303–314.

Research on the Fretting Slip Characteristics of Interference Fit Surface of Train’s Wheelset Running in Heavy Loads

Running under the condition of heavy loads and accelerating status, the fretting damage of wheelset interference fit surface brings great hidden danger to the running safety of the train. Based on heavy loads train equipment parameters and running conditions by using the finite element software ABAQUS finite element model is established and simulated by different axle load and wheel inner hole under the conditions of different amount of interference with the axle wheel seat interference fitted surface fretting slip three-dimensional distribution, and the interference fit different axial location wheel revolving process of three feature points in axial and tangential fretting slip. The results show that the axial fretting slip of the edge of the interference fit surface is much larger than that of the middle, and the outer side is larger than the inner side, with a maximum value 22 µm; tangential fretting slip of interference fit surface reaches the maximum value 9.8µm, when the node rotates by about 270°. The influence of the value of shrink fit on fretting slip is more obvious than that of loads on the axle of the wheelset.

Doing Well by Doing Good: A Study of Corporate Social Responsibility Among Nonprofit Hospitals

Research on corporate social responsibility (CSR) offers mixed findings about the impact of CSR on organizational outcomes and the value of CSR fit with the organization’s core mission. As such, the CSR of nonprofit hospitals offers a valuable opportunity to study CSR fit as these organizations combine a social mission with business- related strategic objectives. The current research presents a theory- driven model of how customer expectations-based dimensions of CSR affect satisfaction. Our demand-based approach (e.g., customer expectations for CSR) advances prior work that has typically focused on supply-side dimensions of CSR (e.g., philanthropic vs. strategic). We address gaps in the CSR literature by: (i) studying CSR within a nonprofit context (over 1,500 nonprofit hospitals in the US) rather than for-profit context, (ii) using actual organizational spending on CSR dimensions rather than self-reported perceptions of CSR, and (iii) utilizing longitudinal data (2009 – 2014) rather than cross- sectional data. Results find that CSR fit alone does not explain organizational outcomes, but rather does so only when CSR goes above and beyond customer expectations. The study also raises an important consideration that how patients rate the quality of their hospital care is influenced by their pre-experience attitudes toward the hospital.

FIT negative cancers: A right-sided problem? Implications for screening and whether iron deficiency anaemia has a role to play

IntroductionFaecal Immunohistochemistry Testing (FIT) is recommended as an adjunct to guide referrals from Primary Care for individuals without rectal bleeding, who do not meet the suspected cancer pathway referral guidelines. It has largely replaced Faecal Occult Blood Testing. AimsTo assess the specificity of FIT. To understand the characteristics of FIT negative cancer patients and whether they have predominantly right sided cancers. Evaluating the efficacy of FIT and Iron deficiency anaemia in combination to capture patients with colorectal cancers. MethodsA study of 1000 symptomatic patients, undergoing FIT by Clinicians during the ‘Digital rectal examination’. Inclusion criteria; all patients referred via our cancer referral pathway. FIT positivity was set at 10 μg g of faeces. ResultsThere were 7 FIT negative cancers in this cohort; 1 was a lymphoma and the other 6 were caecal adenocarcinomas. 5 were anaemic. The positive predictive value of IDA was 34% compared with ‘other symptoms’; 18%. The negative predictive value of FIT was 99.05% in this cohort. Specificity for FIT was 86.9% (CI 96%). ConclusionTwo separate referral pathways for IDA and FIT positive tests, would have captured all patients except 2; the lymphoma and 1 advanced caecal adenocarcinoma. FIT is an excellent triage tool prior to colonoscopy however capturing right sided disease remains a weak point. Multivariate analysis of patients in addition to IDA and FIT should improve capture of this subgroup.

DETERMINATION OF SIMPLE SUGARS IN MEDICINAL PLANT MATERIALS BY THE METHOD OF HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY (FOR EXAMPLE, THE FRUITS OF SEA BUCKTHORN L. AND NETTLE LEAVES L.)

An analysis of the literature over the past 20 years has shown that when controlling the quality of drugs containing monosaccharides, as well as studying the composition of simple sugars in polysaccharide complexes of medicinal plants and not only, preference is given to physicochemical methods, as the most express, sensitive and informative. No means have been found in the scientific literature to identify and quantify simultaneously various monosaccharides by high performance thin layer chromatography (HPTLC). An economical and rapid method has been developed for the identification and quantitative determination of simple reducing sugars (by the example of glucose, rhamnose and xylose) by the HPTLC method. The optimal conditions for their chromatography in a thin layer of sorbent with a quantitative interpretation of HPTLC data on a personal computer were experimentally selected and theoretically substantiated. In a detailed study of the influence of the polarity of the system on the value of Rf, the intervals of values of the polarity of the eluent were chosen, in which these dependences become linear. Using the proposed dependencies, you can select different systems for the separation of monosaccharides in a thin layer of sorbent, so that the value of Rf fit into the optimal values. The proposed method was tested on medicinal plant raw materials of nettle dioica and sea buckthorn fruits of various conservation methods. Zones of simple sugars of characteristic color were found on the chromatograms of extracts from the studied raw materials, among which glucose, xylose and rhamnose were identified by the characteristic value of Rf values in comparison with reliable standard samples. The technique can be used in quality control of substances, single-component and complex preparations, plant objects, dietary supplements, premixes and products of the food industry.

Strong theory testing using the prior predictive and the data prior.

In their seminal article, Roberts and Pashler (2000) highlighted that providing a good fit to empirical data does not necessarily provide strong support for a theory. For a good fit to be persuasive and for a theory to be strongly supported, the theory should have survived a strong test, in the sense that it is plausible that the theory might have failed the test. The most common way to accommodate the problem of the limited value of a good fit alone is to not only report a measure of goodness-of-fit, but also a measure of the complexity. A recent example of this line of reasoning is provided by Veksler, Myers, and Gluck (2015). In this article, I argue that whereas considering complexity provides useful information when theory testing, using complexity to gauge the severity of a test, or, equivalently, the persuasiveness of a good fit, is misguided. The reason is that complexity only provides information about the possibility of a bad fit, which does not guarantee a strong test. A condition for a test to be strong and a good fit to be persuasive is the demonstration of the plausibility of a bad fit. I provide a worked example of a more complete answer to assessing whether a good fit is persuasive. Providing a strong theory test requires the use of what can be called a data prior, which quantifies-before taking the empirical data into account-which outcomes are plausible. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Internal Marketing: Study of Lecturer Organizational Commitments on Private University in Indonesia

The purpose of this research is to examine the organizational commitment model based on a three component of organizational commitment (Meyer, Stanley, Herscovitch, & Topolnytsky, 2002). This research used multidimensional variables that affect organizational commitment in an integrated manner namely religiosity, internal marketing, organizational justice and job satisfaction. The method of data collection was done by using a survey through questionnaire. The number of samples of 200 people used non-probability sampling with a purposive sampling method. Description of respondents' assessments of constructs had a higher mean value than the standard deviation of 4 and 5, which means that the research construct was good and very good. The results of the SEM assumption tests were all normally distributed data with a critical ratio of ± 2.58. Measurement model test results using confirmatory factor analysis (CFA) were all valid indicators which confirmed latent variables. Validity used convergent validity with a loading factor ≥ 0.50. The reliability test resulted construct validity ≥ 0.70, while the results of the variance extracted above ≥0.50. The structural model modification test results can be seen from the goodness of fit that showed the value of good fit. Not all hypotheses were proven, internal marketing affected organizational justice, organizational justice influenced job satisfaction, job satisfaction was proven to affect organizational commitment and internal marketing was proven to influence organizational commitment mediated by organizational justice and job satisfaction. Overall, the results of this research indicated that organizational commitment was influenced by various factors, namely internal marketing, organizational justice and job satisfaction, while religiosity either directly or indirectly did not affect organizational commitment. Keywords : religiosity, internal marketing, organizational justice, job satisfaction, organizational commitment. DOI : 10.7176/EJBM/12-2-06 Publication date: January 31 st 2020

Premature Fecal Immunochemical Testing in British Columbia Canada: a Retrospective Review of Physician and Screening Participant Characteristics.

Colorectal cancer (CRC) screening is an evidence-based strategy to reduce CRC-related mortality. This study identifies physician and participant characteristics, as well as previous FIT values associated with premature FIT usage. This is a retrospective review of all FITs ordered from January 1, 2016, until June 30, 2017. For each ordered FIT, the participant's chart was reviewed to identify if a previous FIT had occurred in the prior 21 months. A premature FIT was defined as an ordered test with a negative FIT in the preceding 21 months. Screening participants were average risk for CRC, aged 50-74, and had a FIT ordered by their primary care provider in British Columbia, Canada. The BC College of Physicians and Surgeons' database was used to identify the location of referring physician, date of graduation from medical school, and gender. The participant's age, gender, and value of previous FIT were recorded. Physician and participant variables and previous FIT value were examined with logistic regression to identify associations with premature FIT ordering. In total, 385,375 FITs were ordered during this period with 116,727 representing participants returning following a previous negative FIT. In total, 35,148 (30.1%) returned early for screening. Men were more likely to return early than women (OR 1.14; 95% CI 1.11-1.17; p < 0.0001). Male physicians were more likely to order premature FITs (OR 1.15; 95% CI 1.06-1.24; p < 0.0001). A higher quantitative FIT value (ng/mL) of the previous FIT was also associated with early screening (OR 1.11; 95% CI 1.09-1.14; < 0.0001). This study found that approximately 30% of FIT tests, ordered for CRC screening, were ordered before they were due. This may lead to wasted resources, unnecessary participant stress, and unwarranted patient risk.

Photocatalytic degradation of ketoconazole by Z-scheme Ag3PO4/graphene oxide: response surface modeling and optimization.

Ketoconazole is an imidazole fungicide which is commonly used as pharmaceutical and healthcare products. Residual amount of this compound can cause adverse ecological health problems. The present study investigated ketoconazole photocatalytic degradation using Ag3PO4/graphene oxide (GO). Ag3PO4/GO and Ag3PO4 as visible light-driven photocatalysts was synthesized using the in situ growth method. Degradation of ketoconazole at the concentration of 1-20 mg/L in aqueous solutions was optimized in the presence of Ag3PO4/GO nanocomposite with the dosage of 0.5-2 g/L, contact time of 15-20 min, and pH of 5-9 using response surface methodology. A second-order model was selected as the best fitted model with R2 value and lack of fit as 0.935 and 0.06, respectively. Under the optimized conditions, the Ag3PO4/GO catalyst achieved a photocatalytic efficiency of 96.53% after 93.34 min. The photocatalytic activity, reaction kinetics, and stability were also investigated. The results indicated that the Ag3PO4/GO nanocomposite exhibited higher photocatalytic activity for ketoconazole degradation, which was 2.4 times that of pure Ag3PO4. Finally, a direct Z-scheme mechanism was found to be responsible for enhanced photocatalytic activity in the Ag3PO4/GO nanocomposite. The high photocatalytic activity, acceptable reusability, and good aqueous stability make the Ag3PO4/GO nanocomposite a promising nanophotocatalyst for photocatalytic degradation of azoles contaminants.

The value of sponsor fit and sincerity when promoting health messages at sport and art events.

Commercial companies invest in sport and arts sponsorship to align their brand with highly engaged spectators. Competing for spectator attention are government and non-government organizations promoting healthy lifestyles. This study investigated spectator engagement on the effectiveness of health messages promoted at sponsored events. Surveys from 2165 adults attending 28 sponsored events collected data on event engagement, health message awareness, behavioral intention, and perceptions of sponsor fit and sincerity. Spectators who were more highly engaged in the event showed significantly greater levels of awareness and acceptance of the health message (all P < 0.01). Path analysis showed that product and event interest were significantly related to both fit and sincerity, and perceived sponsorship fit was significantly associated with greater behavioral intention (all P < 0.01). Product, category and event interest, fit and sincerity were significantly greater for positive advocacy messages than neutral or negative advocacy messages (all P < 0.05). Health message sponsorship is assisted by spectator engagement and perceived fit of sponsored health messages. There exists greater potential to actively leverage spectator engagement to build or reinforce the perceived fit and sincerity of health messages to strengthen existing awareness and behavioral intention.

Evaluating the effect of training along with fit testing on foam earplug users in four factories in China

Objectives: To gain insight into the hearing protection practice of Chinese workers and the value of hearing protection fit testing.Design: The Field Attenuation Estimation System (FAES) was used to measure the personal attenuation ratings (PARs) of one foam earplug used at the work sites in China. Intervention was provided to workers who needed it. Follow-up fit testing was conducted approximately six months later. Paired t-tests were conducted to compare the baseline, post-intervention and follow-up visit PARs.Study sample: Fit testing was conducted on 335 workers in four factories with 269 workers intervened. Follow-up visit was conducted on 97 intervened workers in three factories.Results: The mean PAR baseline was 10 dB. Significant improvement was shown on post-intervention PARs (p < 0.05) as well as follow-up visit PARs (p < 0.05). Comparing follow-up visit PARs to post-intervention PARs, good sustainability was shown in two factories (p > 0.05), while a significant decline (p < 0.05) was observed in another.Conclusions: Hearing protection fit testing demonstrated value for verifying sufficiency of attenuation. The training along with fit testing contributed to improve PARs and maintaining effectiveness over time. Employer’s attention and follow-up actions are important in sustaining the training effectiveness.

ANALYSIS OF 3D SEMI-ELLIPTICAL CRACK ON REACTOR PRESSURE VESSEL WALL WITH LOAD STRESS AND CRACK RATIO

Reactor Pressure Vessel (RPV) wall is an important component in the Nuclear Power Plant (NPP). During reactor operation, RPV is subjected to high temperature, pressure, and neutron exposure. This condition could lead to RPV structure failure. In order to assure the integrity of RPV during the reactor lifetime, it is mandatory to perform a structural integrity assessment of RPV by evaluating postulated crack in RPV. In the previous study, the crack has evaluated in 2-D. However, 3-D analysis of semi-elliptic crack shape in the surface of the thick plate for RPV wall using SA 508 Steel is yet to be analyzed. The objective of this study is to analyze and modeling the evaluation in variation crack ratio with some load stress in 3-D. The Stress Intensity Factor (SIF) and J-integral are used as crack parameter. The J-Integral were calculated using MSC MARC MENTAT based on Finite Element Method (FEM) for obtaining the SIF value. The inputs are a crack ratio, load stress, material property, and geometry. The modeling of SIF value and goodness of fit are using MINITAB. The fracture condition could be predicted in comparison to the SIF value and fracture toughness. For the load stress 70 MPa and 80 MPa, with a crack ratio 0.25, 0.33 and 0.5, the material on RPV wall will in fracture condition.Keywords: Semi elliptic surface crack, 3-dimension, reactor pressure vessel, elastic-plastic fracture mechanics, J-integral

Finite Element Analysis of Uncemented Total Hip Replacement: the Effect of Bone-Implant Interface

Most uncemented total hip replacements (THR) rely on press-fit for the initial stability and thus lead to the secondary fixation which is biological fixation. Choosing the accurate interference fit may have a great effect on implant stability and implant loosening prevention. Implant loosening is the most reported problem where it leads the increasing of micromotion at the bone-implant interface due to insufficient primary fixation. By having sufficient stability or fixation after surgery, minimal relative motion between the prosthesis and bone interfaces allows osseointegration to occur. Therefore, it will provide a strong prosthesis-to-bone biological attachment. The aim of this study was to evaluate the effect of bone-implant interface for uncemented hip implant. In this study, a three-dimensional model of hip implant was designed and analysed by using commercial Finite Element Software namely, ANSYS WORKBENCH V15 software in order to investigate the bone-implant interface effect using the chosen implant design. The value of interference fit (δ= 0.01, 0.05, 0.10 and 0.50 mm) and coefficient of friction (δ= 0.15, 0.40 and 1.00) were used to simulate the bone-implant interface. It was found that the interference fit of 0.50 mm was sufficient to achieve the primary fixation and also the best fitting; thus, the implant loosening can be minimized. The interference fit of 0.50 mm was the minimal value to achieve fixation, while the coefficient of friction did not affect the bone-implant interface.

NIAT ADOPSI TEKNOLOGI INFORMASI: SEBUAH KAJIAN EMPIRIS ONLINE BUSINESS

Penelitian ini menguji hubungan antara variabel dalam Technology Acceptance Model, yang meliputi variabel perceived easy to use, perceived usefulness, sikap, dan niat dengan Theory of Planned Behavior yang mencakup sikap, subjective norm, dan perceived behavioral control. Setting penelitian adalah mahasiswa yang melakukan online business. Pengujian instrumen berdasarkan confirmatory factor analysis untuk pengujian validitas dan cronbach alpha untuk pengujian reliabilitas. Berdasarkan purposive sampling method, terdapat 161 responden yang berpartisipasi dalam penelitian ini. Selanjutnya, pengujian hipotesis menggunakan analisis SEM-GeSCA. Hasil pengujian mengindikasikan bahwa model penelitian fit karena nilai FIT, AFIT, dan GFI berturut-turut sebagai berikut 60,1%; 59,5%;0,989. Oleh karena itu, pengujian hipotesis bisa dilakukan. Terdapat lima hipotesis yang didukung, yakni pengaruh perceived easy to use terhadap perceived usefulness; pengaruh perceived usefulness terhadap sikap dan juga terhadap niat; pengaruh sikap terhadap niat; dan pengaruh perceived behavioral control terhadap niat. Namun hipotesis tentang pengaruh perceived easy to use terhadap sikap dan pengaruh subjective norm terhadap niat tidak didukung.

Get FIT for the new year: a review of the role of faecal immunochemical test for haemoglobin in patients with symptoms of colorectal disease

Colorectal cancer (CRC) incidence is high and whilst the role of colonoscopy in diagnosing CRC in symptomatic individuals is undisputed, there is a need for reliable rule-out criteria to alleviate the burden on the colonoscopy service. Overlap of symptoms that it is often difficult to filter significant colorectal disease from non-significant disease; hence clinical examination needs to be supplemented by further investigation. Biomarkers for CRC have been evaluated in the literature and the faecal immunochemical test for haemoglobin (FIT) is a promising a simple, inexpensive and reproducible tool in both the primary and the secondary care setting. Whilst the value of FIT in CRC screening has been long-established, more recent work has focused on its role in the patient presenting with symptoms of colorectal disease. Negative predictive value of FIT for CRC in patients presenting with symptoms has been shown in the literature to be 100%, with FIT-positive subjects carrying as high as a 60% probability of having CRC. When utilised in a clinical context, and with implementation of safety-netting, FIT is a robust and reliable tool in the patient who presents with symptoms of colorectal disease. FIT-negative, symptomatic patients are unlikely to have significant colonic disease and persisting symptoms should be investigated with cross-sectional imaging instead of colonoscopy.

Improvement of deconvolution–convolution treatment of axial-divergence aberration in Bragg–Brentano geometry

An improved method to correct observed shift and asymmetric deformation of diffraction peak profile caused by the axial-divergence aberration in Bragg–Brentano geometry is proposed. The method is based on deconvolution–convolution treatment applying scale transform of abscissa, Fourier transform, and cumulant analysis of an analytical model for the axial-divergence aberration. The method has been applied to the powder diffraction data of a standard LaB6 powder (NIST SRM660a) sample, collected with a one-dimensional Si strip detector. The locations, widths and shape of the peaks in the deconvolved–convolved powder diffraction data have been analyzed. The finally obtained whole powder diffraction pattern ranging from 10° to 145° in diffraction angle has been simulated by the Pawley method applying a symmetric Pearson VII peak profile model to each peak with ten background, two peak-shift, three line-width, and two peak-shape parameters, and the Rp value of the best fit has been estimated at 4.4%.

Deriving the PRx and CPPopt from 0.2-Hz Data: Establishing Generalizability to Bedmaster Users.

The objective was to explore the validity of industry-parameterized vital signs in the generation of pressure reactivity index (PRx) and optimal cerebral perfusion pressure (CPPopt) values. Ten patients with intracranial pressure (ICP) monitors from 2008 to 2013 in a tertiary care hospital were included. Arterial blood pressure (ABP) and ICP were sampled at 240 Hz (of waveform data) and 0.2 Hz (of parameterized data produced by heuristic industry proprietary algorithms). 240-Hz ABP were filtered for pulse pressure and diastolic ABP within the limits of 20-150 mmHg. The PRx was calculated as Pearson's correlation coefficient using 10-s averages of ICP and ABP over a 5-min moving window with 80% overlap. For ease of comparison, we used the naming convention of BMx for PRx values derived from 0.2-Hz data. A 5-min median cerebral perfusion pressure (CPP) trend was calculated, PRx or BMx values divided and averaged into CPP bins spanning 5 mmHg. The minimum Y value (PRx or BMx) of the parabolic function fit to the resulting XY plot of 4 h of data was obtained, and updated every 1 min. Pearson's R correlations were calculated for each patient. Linear mixed-effects models were used with a random intercept to assess the overall correlation between the PRx (outcome) and the BMx (fixed effect) or the CPPopt-PRx (outcome) and the CPPopt-BMx (fixed effect). The overall correlation between the PRx and BMx was 0.78 based on the linear mixed effects models (p < 0.0001), and the overall correlation for the CPPopt-PRx and CPPopt-BMx based on the linear mixed effects models was 0.76 (p < 0.0001). One patient had low correlation of CPPopts derived from the PRx vs the BMx; this patient had the least number of hours of CPPopt data to compare. The BMx shows promise in CPPopt derivation against the validated PRx measure. If further developed, it could expand the capability of centers to derive CPPopt goals for use in clinical trials.

APPLICATION OF THE FIT FOR DETECTION OF COLORECTAL PATHOLOGY. EXPERIENCE OF YAROSLAVL REGION

AIM. To evaluate the effectiveness and diagnostic value of FIT «Colon View Hb and Hb/Hp» («Colon View»). MATERIALS AND METHODS. The study included 588 patients who underwent FIT «Golon View Hb and Hb/Hp» («Golon View»). RESULTS. When performing a three-time «Colon View» the diagnostic accuracy of the procedure increased for both -for hemoglobin (sensitivity -92,86 specificity - 73,17) and for hemoglobin-haptoglobin complex (sensitivity - 88,1 specificity - 63,41), p<0,05. However, only 39,4 % of patients with a positive «Colon View» test agreed to undergo a colonoscopy. CONCLUSION. Three-fold execution of the FIT «Colon View» increases the diagnostic accuracy of the method, as for Hb andfor Hb/Hp. However, the effectiveness of the test using hemoglobin is higher. Joint use of two indicators (Hb and Hb/Hp) further improves the precision of this model for screening large adenomas and CRC.

Search engine marketing is not all gold: Insights from Twitter and SEOClerks

The study highlights how digital marketing is often detrimental, when it is done by unskilled service providers. It highlights how the hyped services of search engine marketing (SEM) are not as successful as they seem to be and sometimes affect firms negatively. This study uses social media analytics to derive insights from Twitter using descriptive, content and network analytics. Methods like hashtag analysis, polarity and emotion analysis, word analysis, topic modeling and other relevant approaches have been used to mine user generated content. A qualitative case study on an e-market is used for validation of findings. SEM services provided by small organizations and freelancers are not as beneficial as the ones by established players. The services provided by these firms proved detrimental for the customers based on user experiences surrounding these services in the social media and forum specific discussions. This study highlights how SEM often not only fails to provide benefits but also destructs value if not done properly. Transaction costs like agency problems, coordination costs, loss of non-contractible value and cost of fit are also identified with potential fallouts which affect the long-term benefits. Inputs will be beneficial to practice in planning SEM and outsourcing.