This text discusses how the understanding of the Quran on ecology and agriculture has inspired many Islamic scholars and thinkers. It specifically examines Buya Hamka's interpretation of Surah Al-An'am verse 99, which forms the basis for the ecological understanding and agricultural practices within the Quran. The analysis aims to delve into Buya Hamka's views in his interpretation regarding ecological concepts, agricultural practices, as well as the moral and ethical values implied in the verse. Within a historical context, Al-Azhar's interpretation reveals the depth of Buya Hamka's thoughts concerning the relationship between humans, nature, and agricultural practices. Buya Hamka connects the messages of the Quran with the challenges of the time, highlighting the relevance of ecological values and sustainable agricultural practices in modern society. This analysis also explores the educational aspects and environmental awareness advocated in this interpretation, offering perspectives on spirituality and social values in the context of agriculture. Using a historical approach and contemporary relevance mapping, this research elaborates on how Buya Hamka's Al-Azhar interpretation provides a holistic view of ecology and agriculture in the Quran. The conclusion emphasizes the importance of moral, ethical, and practical values derived from Quranic verses related to agriculture. It also offers recommendations for practical implementation in preserving ecosystems and sustaining agriculture in line with Quranic teachings. This analysis contributes to enriching the understanding of the Quran's message concerning ecology and agriculture while providing a foundation for relevant practical applications in environmental preservation and improving agricultural practices in accordance with Islamic teachings.