Valsartan In Treatment Research Articles

Develop and evaluate novel drug delivery system of valsartan for treatment of Hypertension: A review

The sustained release tablets were formulated by using the combination of various release retardant polymers/excipient. The polymers used were hydroxypropyl methylcellulose, Micro Crystalline Cellulose and Sodium starch glycolate. The present investigation involves formulation and evaluation of sustained release tablets of Valsartan with a view to prolong the drug release in the gastrointestinal tract and consequently into the plasma. It showed good linearity and reproducibility which also indicated the analytical method used in the present study to be suitable for the estimation of the drug candidates in different dissolution media. Evaluation parameters such as thickness and diameter, weight variation and drug content uniformity test. The observation for all above evaluation parameters indicate that the values are within the IP specified limits. Thus, on the basis of our research findings it could be concluded that the performance of the developed sustained release tablets was found to be promising for the treatment of hypertension.

Clinical efficacy of Jiawei Dihuang decoction combined with valsartan in treatment of early diabetic nephropathy

One hundred patients with early diabetic nephropathy were randomly divided into control group and study group with 50 cases in each group. All patients received conventional antidiabetic therapy with valsartan tablets 80mg, q. d; patients in study group were given additional TCM Jiawen Dihuang decoction. TCM syndrome scores, relevant biochemical testing and renal function changes were evaluated before and after treatment in two groups. After 8 weeks of treatment, the results showed than the TCM scores in both groups were significantly reduced (study group: 18.9±1.6 vs. 7.2±5.1, control group 18.8±1.5 vs. 10.3±6.2. both P<0.05); the improvement rate of TCM syndrome in study group was significantly higher than that of control group (90% vs. 68%, χ2=5.3, P<0.05) ; and the improvement of relevant biochemical index and renal function in study group was more marked than that in control group. The study indicates that the integrated TCM and Western medicine can enhance the efficacy in treatment of early diabetic hephropathy. Key words: Early diabetic nephropathy; Valsartan Tablets; insulin; TCM therapy; clinical effect

Curative observation on enalapril combined with valsartan in treatment for chronic congestive heart failure

Objective To investigate the method and efficacy of enalapril combined with valsartan treatment for chronic congestive heart failure.Methods 70 selected hospital treated patients with chronic congestive heart failure were randomly and voluntarily divided into two groups,30 cases for control group using only enalapril treatment,40 cases for experimental group using enalapril combined with valsatan treatment.After 1 to 2 months follow-up,they were compared the clinical efficacy and echocardiographic changes.Results Compared between the two groups,total effective rate of experimental group patients was 95.0％,higher than that in control one (76.7％) (P＜ 0.05).The echocardiographic indicators in experimental group were significantly better than those of the control group (P＜ 0.05).Conclusion Application of valsartan combined with enalapril treatment for chronic congestive heart failure can improve the echocardiography indicators and clinical efficacy. Key words: Valsartan; Enalapril; Chronic congestive heart failure

Clinical utility of valsartan in treatment of children and adolescents with high blood pressure

The incidence of hypertension in the pediatric population has been increasing secondary to lifestyle changes in children and adolescents. Recent studies have enhanced our understanding of the treatment of pediatric hypertension. Angiotensin-converting enzyme inhibitors have traditionally been the most commonly used class of medication in children with hypertension. This is partly due to the important role of the renin angiotensin aldosterone system pathway in the mediation of pediatric hypertension. Angiotensin receptor blockers provide a reasonable alternative to angiotensin-converting enzyme inhibitors. The need for better tolerated antihypertensives had led to development of many new antihypertensives. Valsartan is a relatively novel angiotensin receptor blocker that has been shown to be effective in the treatment of pediatric hypertension. Two recent trials have demonstrated the efficacy of valsartan monotherapy in the pediatric population aged 1–16 years. Once-daily oral preparations of valsartan achieve adequate blood pressure control in the pediatric population. Lack of generic formulations is an important disadvantage. Plasma levels are predictable and clearance is primarily by the liver. Valsartan should be prescribed cautiously for sexually active adolescent females due to concern about angiotensin receptor blocker fetopathy. Otherwise, the drug has infrequent side effects. In summary, valsartan is a new and useful alternative to conventional antihypertensive therapy in pediatric population.

Observation of the efficacy of valsartan in treatment of the patients with essential hypertension

Objective To study on the efficacy of valsartan in treatment of the patients with essential hypertension.Methods 80 cases with essential hypertension patients,according to number table,were randomly divided into treatment group and control group in this study.The patients of control and treatment group were treated with captopril(25 mg,tid) and valsartan(80 mg,tid) respectively.Then their clinical efficacies and side effects were observed.Results Treatment group was markedly effective in 23 cases,15 cases of effective,ineffective in 2 cases and the total effective rate was 95%.Meanwhile,control group was 17 cases,13 cases,10 cases and 75% respectively.The total effective rate between the two groups had statistically significant differences(χ2 = 6.275,P＜0.05).After treatment,both of groups' blood pressure,serum uric acid and blood microglobulin levels was obviously lower than before treatment(t = 10.718,4.632,3.865,2.332,23.272,10.628,21.556,14.824,all P＜0.05),moreover,the treatment group decreased more markedly than the control group(t = 12.518,10.719,16.839,12.626,all P＜0.05).There were three cases of adverse reactions in the treatment group,and the control group was four cases.Conclusion This study indicated that valsartan treatment essential hypertension was effective,effects stability,convenience,minor adverse reactions,patient well tolerated,and was one of effective drugs treatment hypertension to prevent target organ damage. Key words: Hypertension; Angiotensin Ⅱ; Valsartan

E0349 Clinical observation on different dosage of valsartan in treatment of heart failure

ObjectiveTo explore the clinical value of different dosage of valsartan in treatment of chronic heartfailure (CHF).Methods99 patient s with CHF were randomly divided into three groups: benazepril group (group A,...