Clinical efficacy of Jiawei Dihuang decoction combined with valsartan in treatment of early diabetic nephropathy

Abstract

One hundred patients with early diabetic nephropathy were randomly divided into control group and study group with 50 cases in each group. All patients received conventional antidiabetic therapy with valsartan tablets 80mg, q. d; patients in study group were given additional TCM Jiawen Dihuang decoction. TCM syndrome scores, relevant biochemical testing and renal function changes were evaluated before and after treatment in two groups. After 8 weeks of treatment, the results showed than the TCM scores in both groups were significantly reduced (study group: 18.9±1.6 vs. 7.2±5.1, control group 18.8±1.5 vs. 10.3±6.2. both P<0.05); the improvement rate of TCM syndrome in study group was significantly higher than that of control group (90% vs. 68%, χ2=5.3, P<0.05) ; and the improvement of relevant biochemical index and renal function in study group was more marked than that in control group. The study indicates that the integrated TCM and Western medicine can enhance the efficacy in treatment of early diabetic hephropathy. Key words: Early diabetic nephropathy; Valsartan Tablets; insulin; TCM therapy; clinical effect