A method was developed and validated for determining the Assay of Rilpivirine in Rilpivirine Tablets by using WATERS HPLC 2695 with Autosampler, PDA Detector and Empower 3 Software. ACE Excel 3 C18 AR (250 x 4.6 mm, 3 μm) column was used along with a mobile phase combination Acetate Buffer: Methanol: Acetonitrile in ratio 60: 30: 10 % v/v/v. Isocratic flow with flowrate of 1.5 mL/minute, Injection volume 12 mL was employed. Column temperature of 30°C was maintained. Detection wave length of Rilpivirine was 258 nm. Run time was optimised to 5 min based on retention time. The retention time of Rilpivirine was 2.29 minutes. The method was found to be specific, linear with a square of correlation coefficient (R2 ) 1.000, accurate over the concentration range of 25 % to 200 %, precise with % RSD of six samples 1.1 and robust. Thus a simple, quick and economical method was developed and validated.