Squamous Cell Carcinoma Of Vagina Research Articles

Primary vaginal squamous cell carcinoma in the young patient

Primary vaginal squamous cell carcinoma in the young patient

The use of Microwave-Induced Hyperthermia in Conjunction with Afterloading Irradiation of Vaginal Carcinoma: A preliminary report

Technically improved microwave antennas for clinical hyperthermia induction have made it possible to combine this treatment modality with external and intracavitary irradiation of vaginal and cervical carcinomas. A microwave applicator with a frequency of 915 MHz was used in tissue phantom measurements and inserted into perspex vaginal obturators for measurement of the specific absorption rate in different planes. A Lund Science Hyperthermia System 4010 with a 200 W generator and a separate thermometry system (ATS 100) was used in the patient treatments. Nine patients with vaginal squamous cell carcinomas have been treated with this applicator and obturator setup as an adjunct to intracavitary irradiation with high dose-rate afterloading technique. The treatments of two patients are described in this preliminary report.

Primary vaginal squamous cell carcinoma in the young patient

This report, prompted by the recent observation of three cases of primary squamous cell carcinoma in relatively young patients, reviews the English-language literature in search of information on age-related incidence for this tumor in the below-40 age group. From those series providing data, it was found that only 10% of these tumors occur in patients less than 40 years old. No authentic squamous cell vaginal cancer could be found in patients less than 10 years of age, and only five such well-documented cases were found in the age group 11–20. The incidence of this tumor then rises abruptly to 60 patients in the age group 21–30 and to 160 patients in the age group 31–40. The rarity of the tumor, particularly with regard to the anatomical location, is impressive as Well as enigmatic.

Amyloid in Squamous Cell Carcinoma of the Vagina

A vaginal squamous cell carcinoma was found to produce amyloid in the more differentiated portion of the tumor. The amyloid was identified by immunohistochemical technique as related to keratin proteins reactive with monoclonal antibodies AE1 and AE3 but not AE2.

Carcinoma of the Vagina

Twenty-two patients with Stage I through IV primary vaginal squamous cell carcinomas treated for cure with radiation therapy are reviewed, with particular emphasis on the relationship of dose to complications and local control. All but 2 patients received 4000 to 6000 rad whole pelvis irradiation plus at least one radium application. Local control was 91%, with an absolute 2-year disease-free survival of 82%. The degree of anaplasia was found to influence prognosis, with all local and distant failures resulting from high-grade lesions. The complication rate was modest, with no fistulae or serious bowel complications. An analysis of total dose (external plus radium) with respect to local failure and complications showed that no major complications occurred at a combined dose below 9000 rad. An analysis of the individual contributions of external irradiation and radium implants showed that all but one very minor complication occurred at a radium dose of 4000 rad or higher. From these data, overall treatment planning and total dose recommendations are made.

Carcinoma of the vagina.

Twenty-two patients with Stage I through IV primary vaginal squamous cell carcinomas treated for cure with radiation therapy are reviewed, with particular emphasis on the relationship of dose to complications and local control. All but 2 patients received 4000 to 6000 rad whole pelvis irradiation plus at least one radium application. Local control was 91%, with an absolute 2-year disease-free survival of 82%. The degree of anaplasia was found to influence prognosis, with all local and distant failures resulting from high-grade lesions. The complication rate was modest, with no fistulae or serious bowel complications. An analysis of total dose (external plus radium) with respect to local failure and complications showed that no major complications occurred at a combined dose below 9000 rad. An analysis of the individual contributions of external irradiation and radium implants showed that all but one very minor complication occurred at a radium dose of 4000 rad or higher. From these data, overall treatment planning and total dose recommendations are made.