To compare outcomes of a voiding trial (VT) performed 2-4 days (early group) versus 7 days (later group) postoperatively in women with acute urinary retention following vaginal prolapse surgery. The secondary aim was to evaluate the effect of narcotic utilization on VT outcomes. Across 2 sites, women undergoing multicompartment native tissue vaginal repair were enrolled. Within 6 hours postoperatively, subjects had an active retrograde VT. Those who passed exited the study; those who failed (PVR >100 ml) had an indwelling catheter replaced and were randomized to return for an early versus later repeat office VT. Subjects were followed for 6 weeks post-surgery. The primary outcome was the rate of failed repeat VT. A power calculation based on projected 31% difference, a power of 0.8, and alpha of 0.05 revealed that 30 subjects were needed in each group. A total of 94 subjects were enrolled; 36 exited on post-operative day 0, leaving 58 subjects for randomization (4 of which withdrew after randomization). A comparison of data revealed that randomization was effective with no differences between the early and later groups in terms of demographic data or surgical procedures (Table 1). Using an intention to treat analysis, women in the early group were more likely to have an unsuccessful repeat VT (26.9%) compared to the latter group (3.6%) with a Relative Risk of 7.53, [95% CI 0.99-57.18], p = 0.01. NNT found that for every 4 patients wearing a catheter for 7 days post-operatively, 1 case of postoperative urinary retention was prevented. Rates of catheter bother did not differ between groups at the time of the repeat office VT or at 6 weeks, p = 0.1181 and p = 0.1226, respectively. UTI rates were higher in the early group but did not reach statistical significance (27% vs 7%, p = 0.0585). Multiple regression analysis revealed that for each unit increase in morphine equivalents on the day of surgery there was a 10% increase in the odds of failing the repeat office VT. Women with acute urinary retention following multicompartment prolapse repair had a 7-fold higher risk of failing a repeat office void trial if performed within 4 days of surgery. In addition, higher total morphine equivalents on the day of surgery increased the risk of an unsuccessful office repeat void trial.