Vaginal Lubrication Research Articles

Association between Vaginal Lubrication Impairment and Tobacco Consumption is Independent of Menopausal Status and Sexual Partner Characteristics: A Multicentre Latin American Sexual Active Mid-Aged Women Analysis.

Association between Vaginal Lubrication Impairment and Tobacco Consumption is Independent of Menopausal Status and Sexual Partner Characteristics: A Multicentre Latin American Sexual Active Mid-Aged Women Analysis.

Effects of estrogen deprivation on expression of aquaporins in rat vagina.

This study aims to investigate the expression of aquaporin (AQP) 0, AQP3, AQP5, AQP6, AQP10, AQP11, and AQP12 in the vaginal tissue of ovariectomized rats. Eight-week-old female Sprague-Dawley rats (n = 18) were randomly divided into three groups: control group (n = 6), ovariectomy group (n = 6), and ovariectomy/estrogen therapy group (n = 6). After 4 weeks, vaginal lubrication level and expression of AQP0, AQP3, AQP5, AQP6, AQP10, AQP11, and AQP12 in vaginal tissue were examined. Serum estrogen level was significantly lower in the ovariectomy group than in the control and ovariectomy/estrogen therapy groups (P < 0.05). Vaginal lubrication was significantly lower in the ovariectomy group (mean [SD], 1.62 [0.30]) than in the control group (mean [SD], 2.37 [0.70]) and ovariectomy/estrogen therapy group (mean [SD], 2.38 [0.73]; P < 0.05). Protein expression of AQP0, AQP3, AQP5, AQP6, AQP10, AQP11, and AQP12 was significantly lower in the ovariectomy group than in the control and ovariectomy/estrogen therapy groups (P < 0.05). Decreased vaginal lubrication in ovariectomized rats after electrostimulation may be partly caused by decreased AQPs in vaginal tissue.

Does surgical menopause affect sexual performance differently from natural menopause?

Hysterectomy is the most common major gynecologic operation, together with bilateral salpingo-oophorectomy in the majority of women over the age of 45. To investigate whether surgical menopause affects female sexual performance differently from natural menopause. The study included 121 women who had undergone surgical menopause and 122 women who had undergone natural menopause. All the women had similar economic, sociocultural, and personal demographic profiles, had been postmenopausal for at least 1 year, and were between the ages of 45 and 65. The women were asked to complete a six-question survey of sexual performance parameters (sexual desire, coital frequency, arousal, orgasm frequency, dyspareunia, and vaginal lubrication). These sexual performance parameters were compared between the surgical and natural menopause groups. With the exception of vaginal lubrication, sexual performance parameters were not statistically different between the two groups (P > 0.05). Vaginal lubrication in the surgically menopausal group was lower than in the naturally menopausal group (P < 0.05). Serum dehydroepiandrosterone sulphate, prolactin, and thyrotropin levels were not statistically different between the groups (P > 0.05), whereas serum estradiol and total testosterone levels in the surgically menopausal group were lower than those of the naturally menopausal group (P < 0.05). The results of this study showed that surgical menopause did not affect female sexual performance differently from natural menopause, with the exception of vaginal lubrication.

Quality of life in postmenopausal women: clinical effects of drospirenone–estradiol administration versus placebo

Objectives: To evaluate the effect of low dose HRT on quality of life. Blood pressure, BMI, joint pain and vaginal lubrication.

Sacral neuromodulation and female sexuality.

An up-to-date review of the impact of a permanent sacral neuromodulation (SNM) implant (Medtronic, Minneapolis, Minnesota, USA) on female sexual function (FSF). Clinical studies published from January 2001 to February 2014 evaluating the impact and/or safety of permanent SNM on FSF were reviewed. Nine studies were selected that investigated the impact on sexual response when the aim of the SNM was to resolve urinary symptoms mainly due to overactive bladder (seven studies) or faecal incontinence. Most women included were of menopausal age. Three studies included sexually inactive women. Post-SNM follow-up varied from 3 to 36months. Meta-analysis of efficacy results was not possible primarily due to the heterogeneity of the sexual and pelvic dysfunctions. The most specific questionnaire assessing FSF was the Female Sexual Function Index (FSFI) used in six studies. During follow-up all women showed statistically significant improvement (p < 0.05) in at least one FSFI domain compared to baseline. In one study statistically significant improvement (p < 0.05) in the FSFI pain domain was exclusively detected in women with neurological disease. Two studies, however, using the questionnaire to screen for sexual dysfunction did not find any statistically significant differences after SNM. The most severe problems associated with FSF concern loss of libido and reduction in vaginal lubrication which were resolved in one woman following removal of the SNM implant. Actual data are still insufficient to definitely assert the positive effect of SNM on FSF.

In vivo estrogenic-like activities of Gouania longipetala Hemsl. (Rhamnaceae) bark extracts in a post-menopause-like model of ovariectomized Wistar rats

Ethnopharmacological relevanceGouania longipetala is commonly used in Cameroonian traditional medicine to manage women fertility and menopausal complaints. However, despite this use, the estrogenic properties of G. longipetala have not been studied until now. Aim of studyThe present study was aimed to assess estrogenic activities of the stem bark aqueous (GLA) and ethanolic (GLE) extracts of G. longipetala in post-menopause-like model of ovariectomized (Ovx) Wistar rats. Material and methodsAnimals were either sham-operated or Ovx. 84 days after ovariectomy, animals were divided into seven groups of five animals and were daily treated for 28 days with distilled water (10mL/kg) for group 1, 2% solution of Tween 80 (10mL/kg) for group 2, estradiol valerate (1mg/kg) for group 3, GLA (45 or 180mg/kg) and GLE (40 or 160mg/kg) for groups 4 to 7 respectively. Sham-operated animals daily received distilled water (10mL/kg). During the experimental period, the body weight was registered every week. At the day 29, blood pressure was registered by invasive method while uterine and vagina morphometry as well as body, uterine and abdominal fat weights changes were analyzed. Serum levels of total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were determined. Moreover, oxidative stress markers such as nitrites, reduced glutathione (GSH) and malondialdehyde (MDA) were measured in homogenized liver and aorta. ResultsCompared with the sham control, vagina and uterine dystrophy and elevated blood pressure were observed in Ovx rats treated with vehicles. Biochemical parameters showed a significant increase of total cholesterol, triglycerides, LDL-cholesterol and MDA as well as a significant decrease of nitrites and GSH in Ovx animals treated with vehicle as compared to sham group. GLA and GLE displayed estrogen-like effects on vagina and did not affect uterine wet weight and epithelial height compared with vehicle groups. Both extracts displayed anti-atherogenic properties by reducing AI, AIP and LDL-cholesterol level as compared to vehicles groups. GLA and GLE significantly prevented the increase of MDA induced by ovariectomy as compared to rats treated with vehicles. ConclusionThis study showed that GLA and GLE exhibited estrogenic effects by providing vaginal lubrication, by modulating blood pressure and improving lipid profile, oxidative status and endothelial function and may not have an undesirable influence on the endometrium in ovariectomized rats.

Assessment of Introital Lubrication.

Vaginal vasocongestion and lubrication serve to prepare the vaginal lumen for sexual activity. Lubrication is important for sexual functioning and difficulties with lubrication are one of the most commonly reported symptoms of sexual dysfunction. Few studies have empirically examined how vasocongestion and lubrication relate to one another and there are currently no well-established measures of lubrication. In this study, we designed and tested a simple method to assess lubrication at the vaginal introitus in 19 healthy women, using litmus test strips. We examined the relationship between lubrication and vaginal vasocongestion (measured with a photoplethysmograph) when elicited by audiovisual sexual stimuli (male-female sexual interactions). Lubrication was elicited by the sexual stimuli and was strongly correlated with reports of sexual arousal. Unexpectedly, lubrication was not correlated with vasocongestion, even though the latter was also elicited by the sexual stimuli. We discuss the implications of these findings for informing our understanding of the female sexual response and the potential clinical and scientific utility of this new measure.

Positive Body Image and Sexual Functioning in Dutch Female University Students: The Role of Adult Romantic Attachment.

This study focused on links between romantic attachment, positive body image, and sexual functioning. Dutch female university students (N = 399) completed an online survey that included self-report items about body appreciation, sexual functioning, and romantic attachment. A proposed conceptual model was tested using structural equation modeling and a good fit to the data was found. Results revealed that attachment avoidance in a romantic context was negatively related to sexual arousal, vaginal lubrication, the ability to reach orgasm, and sexual satisfaction. Attachment anxiety was negatively related to body appreciation which, in turn, was positively related to sexual desire and arousal. Findings indicated that romantic attachment is meaningfully linked to body appreciation and sexual functioning. Therefore, the concept of adult attachment may be a useful tool for the treatment of sexual problems of young women.

Sexual Dysfunction in Depressive Women

Introduction Mental illness has a large effect on sexual function and the expression of sexuality. Many studies have illustrated that sexual dysfunction is significantly associated with depression. Objectifs Assess the quality of sexual response in a population of depressed women. Search factors associated with impaired sexual function. Aims Investigate the degree of correlation between sexual dysfunction and depression. Methodes Analytical and descriptive Study involving 30 sexually active women seen for the first time at the Razi hospital. They presents a first major depressive episode according to DSM IV. Exclusion criteria were the presence of psychotic symptoms, the use of antidepressants in the last three months and inflammatory or neoplastic comorbidity. The severity of depression was assessed by the Beck Depression Scale. The evaluation of sexuality was made ??by Aziona sexual experience scale Results The middle-age was 37 years, 80% were married. Depression was severe in 60% of cases and the average time of care was 3.7 months. Sexual function was altered in 70% of cases with a positive correlation between the severity of depression, the depressive episode duration, and the sexual dysfunction. Sexual desire was the most affected by depression, distorted in more than half of patients. Sexual arousal and vaginal lubrication were also altered in respectively 40% and 36.7% of cases, while orgasm and satisfaction with orgasm were more conserved. Conclusion Taking into account the dimension of sexuality is important in the management of a depressive episode. Early treatment is a protective factor from sexual dysfunction in depressed women.

Prevalence of sexual dysfunction among female patients followed in a Brasília Cohort of early rheumatoid arthritis

ObjectiveTo determine the prevalence of sexual dysfunction in women diagnosed with early rheumatoid arthritis (RA) (less than one year of symptoms at the time of diagnosis), as well as to evaluate the possible association between sexual dysfunction with AR activity and functional disability. MethodsCross-sectional study assessing women diagnosed with early RA, accompanied per protocol in the Brasilia Cohort, Hospital Universitário de Brasília. Demographics, disease activity index (Disease Activity Score 28 – DAS 28) and functional disability questionnaire (Health Assessment Questionnaire – HAQ), were obtained by direct interviews. The Female Sexual Function Index (FSFI) was used questionnaire which contains 19 items that assess six domains: sexual desire, sexual arousal, vaginal lubrication, orgasm, sexual satisfaction and pain. Results68 patients studied, of whom 54 (79.4%) reported sexual activity in the last four weeks. The participants were 49.7±13.7 (mean±SD) years old and the majority were married (61.4%). The mean DAS 28 was 3.6±1.5 and the mean HAQ was 0.7. The prevalence of sexual dysfunction (FSFI ≤26) was 79.6%. There was no association of disease activity or of functional disability with the occurrence of sexual dysfunction in the female patients evaluated. ConclusionThe prevalence of sexual dysfunction found in this study was higher than that reported in the literature in healthy women. A knowledge of the extent of the problem is needed to provide adequate therapeutic options for these patients.

Chapter 13 - Sexual dysfunction in patients with spinal cord lesions

Many aspects of sexuality can be disrupted following a spinal cord lesion (SCL). It can alter an individual's self-esteem and body image, interfere with positioning and mobility, introduce unexpected problems with incontinence and spasticity, decrease pleasure, and delay orgasm. Sexual concerns in men can involve erectile function, essential for intercourse, ejaculation function, necessary for fertility, and the ability to reach orgasm. In women they can involve concerns with vaginal lubrication, genital congestion, and vaginal infections, which can all go unnoticed, and orgasm, which may be lost. All of these concerns must be addressed during rehabilitation as individuals with SCL continue to live an active sexual life, and consider sexuality among their top priority for quality of life. This chapter describes the impact of SCL on various phases of men's and women's sexual responses and on various aspects of sexuality. Treatments are described in terms of what is currently available and what is specific to the SCL population. New approaches in particular for women are described, along with tips from sexual counseling which consider an overall approach, taking into account the primary, secondary, and tertiary consequences of the SCL on the individual's sexuality. Throughout the chapter, attempts are made to integrate neurophysiologic knowledge, findings from the literature on SCL, and clinical experience in sexual rehabilitation.

Sexual dysfunctions in patients with obsessive compulsive disorder

ABSTRACT Objective: Obsessive compulsive disorder (OCD) is known to have a negative impact on sexual functioning. The aim of the present study was to compare patients with OCD and healthy subjects in terms of the sexual dysfunctions. Method: Seventy eight patients, between 18-52 years of age, sexually active who were admitted to the outpatient unit of a university psychiatry department, and who were diagnosed with OCD according to the DSM-IV diagnostic criteria were enrolled in the study. The control group encompassed 60 healthy subjects. The severity of OCD was rated by using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and all participants were evaluated with the Arizona Sexual Experiences Scale (ASEX) for sexual dysfunction. Results: The rate of sexual dysfunction (SD) was determined in 65.4% of OCD patients and 28.3% of the control group. While anorgasmia was the most reported complaint in females with OCD (51.2 %), hypoactive sexual desire was the most reported in males with OCD (18.2 %). ASEX scores of sexual desire, excitement, vaginal lubrication, orgasm and orgasmic satisfaction were found to be significantly higher in females with OCD compared to healthy subjects.While erectile dysfunction was found significantly higher in healthy males compared to OCD patients, no significant difference was found between the two groups for other sexual functions. Conclusion: In this study, all phases of sexual function were impaired in females with OCD. Though orgasmic dysfunction was identified as the most common sexual dysfunction in females with OCD, this issue is controversial. We did not detect a significant sexual dysfunction in males with OCD, and these findings may suggest that antidepressant drugs might have a positive effect on sexual dysfunction in males or at least did not cause a significant negative effect on sexual functions in male patients.

Female Sexual Dysfunctions in Diabtes Mellitus: Prevalence Risk Factor and Diagnosis

Diabetes mellitus is a chronic metabolic disorder in almost all countries. The secondary complications may include female sexual dysfunctions (FSDs) which are characterized by decreased libido, anorgasmia, dyspareunia and psycho-physiological disturbances. 40–60% FSD cases are reported each year worldwide with increased late menopause period (4288%), insufficient vaginal lubrication (5–28%), orgasmic disorder (5%) and dyspareunia (3–12%). Etiologies of FSD are doubtful but certain physiological and psychological factors are involved in its contribution. The other risk factors for diabetes associated FSD include cardiovascular disease, hypertension, genitourinary disease, psychological disorder, cancer and other chronic diseases. Subject's history with physiological and psychological attribute is the basis for FSD diagnosis. Currently no specific treatment is available to treat FSD but its risk factors and complications may be controlled with the help of pharmacological, non-pharmacologic treatment and hormonal replacement therapy.

Chapter 11 - Sexual dysfunction in patients with peripheral nervous system lesions

Peripheral nervous system (PNS) disorders may cause sexual dysfunction (SD) in patients of both genders. These disorders include mainly polyneuropathies (particularly those affecting the autonomic nervous system (ANS)) and localized lesions affecting the innervation of genital organs. Impaired neural control may produce a malfunction of the genital response consisting of loss of genital sensitivity, erectile dysfunction, loss of vaginal lubrication, ejaculation disorder, and orgasmic disorder. In addition, there is often a loss of desire which actually has a complex pathogenesis, which goes beyond the mere loss of relevant nerve function. In patients who have no manifest health problems - particularly men with erectile dysfunction - one should always consider the possibility of an underlying polyneuropathy; in patients with SD after suspected denervation lesions of the innervation of genital organs within the lumbosacral spinal canal and in the pelvis, clinical neurophysiologic testing may clarify the PNS involvement. SD can alter self-esteem and lower patients' quality of life; opening up a discussion on sexual issues should be a part of the management of patients with PNS disorders. They may greatly benefit from counseling, education on coping strategies, and specific treatments.

Sexuality and chronic pain in long-lived females: description of interferential factors

BACKGROUND AND OBJECTIVES: Approximately 60% of chronic pain individuals complain of sexual dysfunction, the prevalence of which varies from 20 to 88%. Among sexual complaints most reported by elderly females there are low interest, difficult vaginal lubrication and inability to reach orgasm. This study aimed at checking the prevalence of sexual dysfunction among long-lived females with chronic pain and at describing interfering factors. METHODS: This was a descriptive, analytical and cross-sectional study with females above 80 years of age. Data were collected on demographics, comorbidities and use of drugs, in addition to chronic pain evaluation and measurement and identification of sexual dysfunctions by the Short Personal Experiences Questionnaire. RESULTS: Participated in the study 32 elderly females, with mean age of 87 years, most of them widows, with less than 4 years of education, good self-reported health, without sexual partner and with primarily osteoarthritis-induced nociceptive pain.The prevalenceof sexual dysfunctionwasfoundtobe 78% ofelderlywithchronicpainwith a mean score of7. Major reason for sexual inactivity was lack of a partner. In approximately 28.1% it was observed that chronic pain would interfere with sexuality. It was also observed that no elderly female had been previously addressed as to their sexuality, although 68.8% have stated that would have liked to be addressed. CONCLUSION: Chronic pain was considered a factor interfering with sexual practices of studied long-lived females, suggesting that this symptom may impair sexuality during aging.

How changes in depression and anxiety symptoms correspond to variations in female sexual response in a nonclinical sample of young women: a daily diary study.

A large body of literature supports the co-occurrence of depression, anxiety, and sexual dysfunction. However, the manner in which affective symptoms map onto specific female sexual response indices is not well understood. The present study aimed to examine changes in depression and anxiety symptoms and their correspondence to fluctuations in desire, subjective arousal, genital response, orgasmic function, and vaginal pain. The study used a 2-week daily diary approach to examine same-day and temporal relations between affective symptoms and sexual function. The unique relations between shared and disorder-specific symptoms of depression and anxiety (i.e., general distress, anhedonia, and anxious arousal) and female sexual response (i.e., desire, subjective arousal, vaginal lubrication, orgasmic function, and sexual pain) were examined, controlling for baseline levels of sexual distress, depression, and anxiety, as well as age effects and menstruation. Analyses revealed that changes in depression and anxiety severity corresponded to same-day variations in sexual response. Specifically, anhedonia (depression-specific symptom) was related to poorer same-day sexual desire, whereas greater anxious arousal (anxiety-specific symptom) was independently related to simultaneous increases in subjective sexual arousal, vaginal lubrication, and sexual pain. Increases in general distress (i.e., shared symptoms) were associated with greater same-day difficulties achieving orgasm. Notably, only one temporal relation was found; it indicated that higher levels of anhedonia predicted a next-day decrease in sexual desire. It is proposed that the simultaneous changes in affective symptoms and sexual function may indicate that they are products of shared underlying mechanisms. That is, in response to stress, the processes manifesting as feelings of weak positive affect and amotivation are the very same processes responsible for diminished capacity for sexual desire. In contrast, the physiological hyperarousal associated with anxiety also gives rise to sexual arousal difficulties and vaginal pain.

Daily affect and female sexual function.

The specific affective experiences related to changes in various aspects of female sexual function have received little attention as most prior studies have focused instead on the role of clinical mood and anxiety disorders and their influence on sexual dysfunction. We sought to understand the transaction between daily affect and female sexual function in effort to provide a more nuanced understanding of the interplay between affective and sexual experiences. The present study used a 2-week daily diary approach to examine same-day and temporal relations between positive and negative affect states and sexual function in young women. We examined the unique relations between positive (i.e., joviality, serenity, self-assurance) and negative (i.e., fear, sadness, hostility) affects and female sexual response (i.e., desire, subjective arousal, vaginal lubrication, orgasmic function, and sexual pain) while controlling for higher order sexual distress, depression, and anxiety, as well as age effects and daily menstruation. Analyses revealed different aspects of both positive and negative affects to be independently related to sexual response indices. Specifically, results indicated that joviality was related to same-day sexual desire and predicted increased desire the following day. This latter relation was partially mediated by sexual activity. Further, greater sexual desire predicted next-day calmness, which was partially mediated by sexual activity. Notably, fear was related to same-day subjective arousal, lubrication, orgasmic function, and vaginal pain, whereas poorer orgasmic function predicted greater next-day sadness. These findings describe the manner in which changes in affect correspond to variations in female sexual function, thus highlighting the inextricability of mental and sexual health. Further, these findings may offer insight into the progression of normative levels of affect and sexual function as they develop into comorbid depression, anxiety, and sexual dysfunction.

Prevalência de disfunção sexual entre pacientes acompanhadas na coorte Brasília de artrite reumatoide inicial

ObjectiveTo determine the prevalence of sexual dysfunction in women diagnosed with early rheumatoid arthritis (RA) (less than one year of symptoms at the time of diagnosis), as well as to evaluate the possible association between sexual dysfunction with AR activity and functional disability. MethodsCross‐sectional study assessing women diagnosed with early RA, accompanied per protocol in the Brasilia Cohort, Hospital Universitário de Brasília. Demographics, disease activity index (Disease Activity Score 28 – DAS 28) and functional disability questionnaire (Health Assessment Questionnaire – HAQ), were obtained by direct interviews. The Female Sexual Function Index (FSFI) was used, questionnaire which contains 19 items that assess six domains: sexual desire, sexual arousal, vaginal lubrication, orgasm, sexual satisfaction and pain. Results68 patients studied, of whom 54 (79.4%) reported sexual activity in the last four weeks. The participants were 49.7±13.7 (mean±SD) years old and the majority were married (61.4%). The mean DAS 28 was 3.6±1.5 and the mean HAQ was 0.7. The prevalence of sexual dysfunction (FSFI ≤26) was 79.6%. There was no association of disease activity or of functional disability with the occurrence of sexual dysfunction in the female patients evaluated. ConclusionThe prevalence of sexual dysfunction found in this study was higher than that reported in the literature in healthy women. A knowledge of the extent of the problem is needed to provide adequate therapeutic options for these patients.

Is It Hot in Here? Menopause Symptom Management

Is It Hot in Here? Menopause Symptom Management

Acupuncture for the Treatment of Vulvodynia

PurposeA randomized controlled pilot study was conducted to evaluate the effect of an acupuncture protocol for the treatment of vulvodynia.Hypotheses1) Acupuncture reduces vulvar pain and dyspareunia in women with vulvodynia. 2) Acupuncture increases sexual function in women with vulvodynia.SignificanceThe incidence of vulvodynia in US women has been reported to be as high as 16%. Research suggests that there is no consistently effective standardized treatment for vulvodynia.MethodsThirty‐six women with vulvodynia met inclusion criteria, and 36 women completed the study. The women were randomly assigned either to the acupuncture group or to the wait‐list control group. The 18 participants assigned to the acupuncture group received acupuncture 2 times per week for 5 weeks for a total of 10 sessions.ResultsVulvar pain and dyspareunia showed statistically significant reductions, and sexual function showed a statistically significant increase for women in the acupuncture group as compared to the wait‐list control group. Acupuncture showed a trend for increased vaginal lubrication and reduced affective pain. Acupuncture did not increase sexual desire, sexual arousal, ability to orgasm, or sexual satisfaction in women with vulvodynia.DiscussionThis was the first randomized controlled pilot study to examine the use of acupuncture for the treatment of vulvodynia. The acupuncture protocol was feasible and in this small sample reduced vulvar pain and dyspareunia, and increased sexual function in women with vulvodynia. This study should be replicated in a larger double‐blind randomized controlled trial, and if results indicate, this acupuncture treatment protocol should be considered a valid and important option in the treatment of this incapacitating pain syndrome.