INTRODUCTION: Hypertensive diseases of pregnancy complicate approximately 10% of pregnancies. Optimal timing and mode of delivery is unclear for pregnancies complicated by early onset pre-eclampsia with severe features (<34 weeks). This study aims to identify characteristics associated with the patient, fetus, and pregnancy that may affect the likelihood of successful vaginal delivery, which may guide future counseling of these patients. METHODS: This is a retrospective cohort study of women at a large tertiary medical center from 2012-2016. It included a total of 159 patients who delivered at <34 weeks with pregnancies complicated by pre-eclampsia with severe features. Risk factors for failed induction of labor were compared using various statistical methods. We developed and validated a predictive model using a step-wise procedure to calculate a patient's risk for having a failed induction of labor. RESULTS: Of 159 patients who underwent induction of labor, 77 resulted in successful vaginal deliveries. History of prior vaginal delivery, history of preterm labor, and increased parity, were associated with successful induction of labor. Conversely, elevated umbilical artery dopplers, earlier gestational age, lower bishop score, and current smoking were associated with higher rates of cesarean delivery. CONCLUSION: Overall, 48.4% of patients delivered vaginally following induction of labor in the setting of early onset pre-eclampsia with severe features. We developed a predictive model to classify patients with regards to risk for cesarean section, which included the following variables: pregnancy history, bishop score, age, smoking status, obesity. Further research can better elucidate the impact of different characteristics in predicting mode of delivery.
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